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ENZYME

ENZYME entry: EC 3.6.1.15

Accepted Name
nucleoside-triphosphate phosphatase
Alternative Name(s)
NTPase
nucleoside 5-triphosphatase
nucleoside-5-triphosphate phosphohydrolase
nucleoside-triphosphatase
nucleoside triphosphate hydrolase
nucleoside triphosphate phosphohydrolase
Reaction catalysed
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate
Comment(s)
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
Cross-references
BRENDA3.6.1.15
EC2PDB3.6.1.15
ExplorEnz3.6.1.15
PRIAM enzyme-specific profiles3.6.1.15
KEGG Ligand Database for Enzyme Nomenclature3.6.1.15
IUBMB Enzyme Nomenclature3.6.1.15
IntEnz3.6.1.15
MEDLINEFind literature relating to 3.6.1.15
MetaCyc3.6.1.15
Rhea expert-curated reactions3.6.1.15
UniProtKB/Swiss-Prot
Q3ZC91, ASM3A_BOVINQ92484, ASM3A_HUMANP70158, ASM3A_MOUSE
Q641Z7, ASM3A_RATP0C218, DDX20_DANREQ9UHI6, DDX20_HUMAN
Q9JJY4, DDX20_MOUSEQ9Y227, ENTP4_HUMANQ9DBT4, ENTP4_MOUSE
Q9NQZ7, ENTP7_HUMANQ3TCT4, ENTP7_MOUSEQ5REF6, ENTP7_PONAB
Q28CF8, ENTP7_XENTRC3PCY9, NTDP_BACAAC3LHA4, NTDP_BACAC
A0R9G2, NTDP_BACAHQ81YV4, NTDP_BACANB7JNG2, NTDP_BACC0
Q73DX8, NTDP_BACC1B7IW18, NTDP_BACC2C1EWG2, NTDP_BACC3
B7H9S1, NTDP_BACC4B7HU62, NTDP_BACC7A7GKZ6, NTDP_BACCN
B9J2V8, NTDP_BACCQQ81I89, NTDP_BACCRQ63GB8, NTDP_BACCZ
Q6HNT2, NTDP_BACHKQ65M90, NTDP_BACLDA9VSS3, NTDP_BACMK
A8FB84, NTDP_BACP2Q796Z1, NTDP_BACSUA7Z2N5, NTDP_BACVZ
Q837X8, NTDP_ENTFAQ5L2S7, NTDP_GEOKAC5D5T7, NTDP_GEOSW
A4IKK1, NTDP_GEOTNQ9KEB3, NTDP_HALH5Q74IG4, NTDP_LACJO
Q9CGX3, NTDP_LACLAA2RLF8, NTDP_LACLMQ02ZN0, NTDP_LACLS
Q88XG4, NTDP_LACPLQ38VK6, NTDP_LATSSQ1WV02, NTDP_LIGS1
Q92AX3, NTDP_LISINC1KVY6, NTDP_LISMCQ71YY0, NTDP_LISMF
B8DFN5, NTDP_LISMHQ8Y6J7, NTDP_LISMOA0AJE1, NTDP_LISW6
Q8CV58, NTDP_OCEIHQ5WIF2, NTDP_SHOC1A7X3Y3, NTDP_STAA1
A6U2X1, NTDP_STAA2Q2FFM8, NTDP_STAA3Q2G2M8, NTDP_STAA8
A5IU33, NTDP_STAA9Q2YU19, NTDP_STAABQ5HEQ7, NTDP_STAAC
A6QI49, NTDP_STAAEQ99T12, NTDP_STAAMQ7A4T2, NTDP_STAAN
Q6GFJ0, NTDP_STAARQ6G867, NTDP_STAASA8YY39, NTDP_STAAT
Q7A0J0, NTDP_STAAWB9DMW9, NTDP_STACTQ5HN67, NTDP_STAEQ
Q8CRW4, NTDP_STAESQ4L7H2, NTDP_STAHJQ49YR2, NTDP_STAS1
Q3K2X3, NTDP_STRA1Q8E6W2, NTDP_STRA3Q8E1E5, NTDP_STRA5
C0M6F4, NTDP_STRE4B4U4F8, NTDP_STREMA8AVW8, NTDP_STRGC
Q8DSK1, NTDP_STRMUQ99YP1, NTDP_STRP1Q04IQ6, NTDP_STRP2
P0DH22, NTDP_STRP3B5E217, NTDP_STRP4Q5XAR1, NTDP_STRP6
C1C9H3, NTDP_STRP7Q7CMZ3, NTDP_STRP8Q1JAL4, NTDP_STRPB
Q1JKR7, NTDP_STRPCQ1JFQ7, NTDP_STRPDQ1J5K6, NTDP_STRPF
A2RD86, NTDP_STRPGB1I8B0, NTDP_STRPIB8ZNK8, NTDP_STRPJ
Q48S38, NTDP_STRPMQ97NV6, NTDP_STRPNP0DH23, NTDP_STRPQ
B2ILZ2, NTDP_STRPSB5XMG7, NTDP_STRPZQ8DNH5, NTDP_STRR6
A4VZQ1, NTDP_STRS2C0MH45, NTDP_STRS7A3CPV9, NTDP_STRSV
A4VTH2, NTDP_STRSYQ5M192, NTDP_STRT1Q5M5S9, NTDP_STRT2
Q03M63, NTDP_STRTDB9DV30, NTDP_STRU0C1CGD3, NTDP_STRZJ
C1CML6, NTDP_STRZPC1CTD2, NTDP_STRZTP29814, NTP1_AMEPV
Q18411, NTP1_CAEELP24486, NTP1_CBEPVO91729, NTP1_CFEPV
O72907, NTP1_FOWPNO37319, NTP1_HAEPVQ98267, NTP1_MCV1
A0A7H0DN95, NTP1_MONPVQ9YW39, NTP1_MSEPVQ9Q8L4, NTP1_MYXVL
Q9Q8Z2, NTP1_RFVKAQ08513, NTP1_SWPVKQ27893, NTP1_TOXGO
O57214, NTP1_VACCAP20637, NTP1_VACCCP05807, NTP1_VACCW
P0DOQ3, NTP1_VAR67P0DOQ4, NTP1_VARVQ9QB93, NTP1_YMTV5
Q27895, NTP2_TOXGOP52913, NTP4_TOXGOP52914, NTPA_PEA
Q1LZ78, NTPCR_BOVINQ9BSD7, NTPCR_HUMANQ9CQA9, NTPCR_MOUSE
Q9YDY8, NTPTH_AERPEO67322, NTPTH_AQUAEO29444, NTPTH_ARCFU
A8MB70, NTPTH_CALMQA2BL86, NTPTH_HYPBUA8ABE2, NTPTH_IGNH4
B1L726, NTPTH_KORCOQ8TKK3, NTPTH_METACQ467J7, NTPTH_METBF
Q58954, NTPTH_METJAQ8TX49, NTPTH_METKAA4YEP4, NTPTH_METS5
O27140, NTPTH_METTHB2A6V4, NTPTH_NATTJQ6L2J8, NTPTH_PICTO
Q9UZ81, NTPTH_PYRABQ8ZTE6, NTPTH_PYRAEA4WLK1, NTPTH_PYRAR
A3MX10, NTPTH_PYRCJQ8TH18, NTPTH_PYRFUO58522, NTPTH_PYRHO
A1RRZ4, NTPTH_PYRILB1Y9N2, NTPTH_PYRNVQ97WP0, NTPTH_SACS2
A3DNY5, NTPTH_STAMFQ4JCN8, NTPTH_SULACQ96YL7, NTPTH_SULTO
Q9HJH0, NTPTH_THEACQ5JF42, NTPTH_THEKOQ9WXP3, NTPTH_THEMA
A5IL32, NTPTH_THEP1A1RYX5, NTPTH_THEPDB1LAB2, NTPTH_THESQ
Q97AR1, NTPTH_THEVOP11125, P4_BPPH6Q9YLS4, POLG_AEVCA
Q6WQ42, POLG_AEVL2Q6R325, POLG_AEVVRQ91B85, POLG_ALKV
C8XPA8, POLG_BANVQ288N7, POLG_BECN1Q8JN60, POLG_BECNB
P12915, POLG_BOVEVQ32ZE0, POLG_BUSVQ96662, POLG_BVDVC
P19711, POLG_BVDVNQ01499, POLG_BVDVSQ8V736, POLG_CACV4
P19712, POLG_CSFVAP21530, POLG_CSFVBQ65900, POLG_CX16G
Q9QF31, POLG_CX16TP22055, POLG_CXA21P36290, POLG_CXA24
P21404, POLG_CXA9P08291, POLG_CXB1JQ9YLG5, POLG_CXB2O
P03313, POLG_CXB3NQ66282, POLG_CXB3WQ86887, POLG_CXB4E
P08292, POLG_CXB4JQ03053, POLG_CXB5PQ9QL88, POLG_CXB6S
P27909, POLG_DEN1BP33478, POLG_DEN1SP17763, POLG_DEN1W
P29990, POLG_DEN26P29991, POLG_DEN27P14337, POLG_DEN28
P07564, POLG_DEN2JP14340, POLG_DEN2NP12823, POLG_DEN2P
Q9WDA6, POLG_DEN2QP27914, POLG_DEN2TQ99D35, POLG_DEN3C
Q5UB51, POLG_DEN3IQ6YMS3, POLG_DEN3MP27915, POLG_DEN3P
Q6YMS4, POLG_DEN3SP09866, POLG_DEN4DQ2YHF2, POLG_DEN4H
Q58HT7, POLG_DEN4PQ5UCB8, POLG_DEN4SQ2YHF0, POLG_DEN4T
Q96725, POLG_EBHSGO91734, POLG_EC01FQ9YLJ1, POLG_EC05N
Q66474, POLG_EC06CQ66577, POLG_EC09BQ66849, POLG_EC09H
P29813, POLG_EC11GQ66575, POLG_EC12TQ9WN78, POLG_EC30B
C8XPB2, POLG_EHVN0A3C0, POLG_FCVP27407, POLG_FCVC6
P27408, POLG_FCVF4P27409, POLG_FCVF9Q66914, POLG_FCVUR
A2I7M2, POLG_FMDA1Q9Q2N9, POLG_FMDS2P03306, POLG_FMDV1
P03307, POLG_FMDV5P03308, POLG_FMDVAP03309, POLG_FMDVC
P03310, POLG_FMDVIP03305, POLG_FMDVOQ6PMV1, POLG_FMDVP
P03311, POLG_FMDVSP15072, POLG_FMDVTP49303, POLG_FMDVZ
Q69422, POLG_GBVBQ8V0N6, POLG_HAV88Q5Y944, POLG_HAVCF
Q67825, POLG_HAVGBA3FMB2, POLG_HAVH2Q05794, POLG_HAVHA
P08617, POLG_HAVHMA5LGW7, POLG_HAVJ8P06441, POLG_HAVLA
P13901, POLG_HAVMBQ9DWR1, POLG_HAVNOP14553, POLG_HAVS2
P26664, POLG_HCV1Q5I2N3, POLG_HCV6AP27958, POLG_HCV77
Q68749, POLG_HCVBBP26663, POLG_HCVBKQ9WMX2, POLG_HCVCO
O39929, POLG_HCVEDO39927, POLG_HCVEUO39928, POLG_HCVEV
Q81754, POLG_HCVH9Q913D4, POLG_HCVINQ03463, POLG_HCVJ1
O92972, POLG_HCVJ4P26660, POLG_HCVJ6P26661, POLG_HCVJ8
P26662, POLG_HCVJAQ99IB8, POLG_HCVJFQ68801, POLG_HCVJK
Q68798, POLG_HCVJLQ9DHD6, POLG_HCVJPQ00269, POLG_HCVJT
Q81495, POLG_HCVK3Q81258, POLG_HCVNZQ913V3, POLG_HCVR6
O91936, POLG_HCVSAO92529, POLG_HCVT5Q81487, POLG_HCVTR
P29846, POLG_HCVTWQ9QAX1, POLG_HCVVAO92530, POLG_HCVVN
O92531, POLG_HCVVOO92532, POLG_HCVVPP32537, POLG_HE701
B9VUU3, POLG_HE71Q66478, POLG_HE71BQ66479, POLG_HE71M
Q68T42, POLG_HED68Q66578, POLG_HPE1HO73556, POLG_HPE2W
Q9YID8, POLG_HPEV5P03303, POLG_HRV14E5D8F2, POLG_HRV15
Q82122, POLG_HRV16P23008, POLG_HRV1AP12916, POLG_HRV1B
P04936, POLG_HRV2Q82081, POLG_HRV3P07210, POLG_HRV8A
Q32ZD7, POLG_ILHVP27395, POLG_JAEV1P19110, POLG_JAEV5
P32886, POLG_JAEVJG3FEX6, POLG_JAEVMP14403, POLG_JAEVN
D7RF80, POLG_KFDVQ32ZD5, POLG_KOKVP14335, POLG_KUNJM
P29837, POLG_LANVTP22338, POLG_LIVQ8JV21, POLG_LJUV1
P54634, POLG_LORDVP33515, POLG_MCFAQ80J95, POLG_MNV1
P05769, POLG_MVEV5Q83883, POLG_NVN68Q7T6D2, POLG_OHFV
Q9QEJ5, POLG_PESVO41174, POLG_PEV9UP03300, POLG_POL1M
P03301, POLG_POL1SP06210, POLG_POL2LP23069, POLG_POL2W
P06209, POLG_POL32P03302, POLG_POL3LQ04538, POLG_POWVL
P27411, POLG_RHDV3Q86119, POLG_RHDVAQ89273, POLG_RHDVB
P27410, POLG_RHDVFQ86117, POLG_RHDVSQ32ZD4, POLG_ROCV
P36286, POLG_SMSV1P36287, POLG_SMSV4Q04544, POLG_SOUV3
P09732, POLG_STEVMP16604, POLG_SVDVHP13900, POLG_SVDVU
Q6XDK8, POLG_SVM10Q69014, POLG_SVM93Q672I1, POLG_SVSAP
Q01299, POLG_TBEVHP07720, POLG_TBEVSP14336, POLG_TBEVW
Q5WPU5, POLG_USUVQ9DUN3, POLG_VESVAP06935, POLG_WNV
Q9Q6P4, POLG_WNV9C5H431, POLG_WSLVP03314, POLG_YEFV1
Q6DV88, POLG_YEFVAQ6J3P1, POLG_YEFVCQ074N0, POLG_YEFVE
Q89277, POLG_YEFVFQ98803, POLG_YEFVIQ1X881, POLG_YEFVN
Q9YRV3, POLG_YEFVTQ1X880, POLG_YEFVUQ32ZE1, POLG_ZIKV
A0A024B7W1, POLG_ZIKVFA0A142I5B9, POLG_ZIKVKQ86924, POLN_AURAV
P87515, POLN_BFVQ5XXP4, POLN_CHIK3Q8JUX6, POLN_CHIKS
Q306W6, POLN_EEEV1Q306W8, POLN_EEEV8Q4QXJ8, POLN_EEEVF
P36327, POLN_EEVV3Q8V294, POLN_EEVVCQ9WJC7, POLN_EEVVM
P36328, POLN_EEVVPP27282, POLN_EEVVTQ5Y389, POLN_GETV
Q8QZ73, POLN_MAYABP13886, POLN_ONNVGO90370, POLN_ONNVI
O90368, POLN_ONNVSP13887, POLN_RRVNQ6X2U4, POLN_RUBVB
Q6X2U2, POLN_RUBVCQ9J6K9, POLN_RUBVDQ86500, POLN_RUBVM
Q8BCR0, POLN_RUBVNQ99IE7, POLN_RUBVOO40955, POLN_RUBVR
P13889, POLN_RUBVTQ99IE5, POLN_RUBVVQ9JGL0, POLN_SAGV
P08411, POLN_SFVP27283, POLN_SINDOP03317, POLN_SINDV
Q8QL53, POLN_SLDVQ8JJX1, POLN_SPDVP13896, POLN_WEEV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-