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ENZYME entry: EC 3.6.1.22

Accepted Name
NAD(+) diphosphatase.
Alternative Name(s)
NADH pyrophosphatase.
NADP pyrophosphatase.
Nicotinamide adenine dinucleotide pyrophosphatase.
Reaction catalysed
NAD(H) + H(2)O <=> AMP + NMN(H)
Comment(s)
  • This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences.
  • Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).
Cross-references
PROSITEPDOC00695
BRENDA3.6.1.22
EC2PDB3.6.1.22
ExplorEnz3.6.1.22
PRIAM enzyme-specific profiles3.6.1.22
KEGG Ligand Database for Enzyme Nomenclature3.6.1.22
IUBMB Enzyme Nomenclature3.6.1.22
IntEnz3.6.1.22
MEDLINEFind literature relating to 3.6.1.22
MetaCyc3.6.1.22
Rhea expert-curated reactions3.6.1.22
UniProtKB/Swiss-Prot
Q19427, NPY1_CAEEL;  Q9Y7J0, NPY1_SCHPO;  P53164, NPY1_YEAST;  
Q6NPD7, NUD10_ARATH;  Q29RH3, NUD12_BOVIN;  Q9BQG2, NUD12_HUMAN;  
Q4R7L8, NUD12_MACFA;  Q9DCN1, NUD12_MOUSE;  Q5RD76, NUD12_PONAB;  
Q86X67, NUD13_HUMAN;  Q8JZU0, NUD13_MOUSE;  Q94A82, NUD19_ARATH;  
A6VQT1, NUDC_ACTSZ;  Q7NTZ8, NUDC_CHRVO;  A8AKS7, NUDC_CITK8;  
A7MJ81, NUDC_CROS8;  Q9RV62, NUDC_DEIRA;  A7ZUL1, NUDC_ECO24;  
B7UPF1, NUDC_ECO27;  B7MIY2, NUDC_ECO45;  B7LA85, NUDC_ECO55;  
Q8X6X7, NUDC_ECO57;  B5Z092, NUDC_ECO5E;  B7NRS9, NUDC_ECO7I;  
B7N2J8, NUDC_ECO81;  B7M7Q5, NUDC_ECO8A;  C5A0T7, NUDC_ECOBW;  
B1XBZ9, NUDC_ECODH;  A8A796, NUDC_ECOHS;  A1AIG7, NUDC_ECOK1;  
Q0TA69, NUDC_ECOL5;  Q8FB75, NUDC_ECOL6;  B1IUQ1, NUDC_ECOLC;  
P32664, NUDC_ECOLI;  B7NFT7, NUDC_ECOLU;  B6I5K7, NUDC_ECOSE;  
B1LNU8, NUDC_ECOSM;  Q1R5W2, NUDC_ECOUT;  C5BHE7, NUDC_EDWI9;  
A4W5B9, NUDC_ENT38;  B2VG76, NUDC_ERWT9;  B7LUK6, NUDC_ESCF3;  
Q4QNB3, NUDC_HAEI8;  A5UA57, NUDC_HAEIE;  A5UGU3, NUDC_HAEIG;  
P44710, NUDC_HAEIN;  B5XYE2, NUDC_KLEP3;  A6TGQ3, NUDC_KLEP7;  
Q65W71, NUDC_MANSM;  Q7TX14, NUDC_MYCBO;  A1KNJ7, NUDC_MYCBP;  
C1AGW8, NUDC_MYCBT;  A5U7L9, NUDC_MYCTA;  P9WIX4, NUDC_MYCTO;  
P9WIX5, NUDC_MYCTU;  P57965, NUDC_PASMU;  Q6DAL8, NUDC_PECAS;  
C6DHS8, NUDC_PECCP;  Q7N961, NUDC_PHOLL;  Q6LLW5, NUDC_PHOPR;  
Q48IH8, NUDC_PSE14;  A6V6Z8, NUDC_PSEA7;  B7VB54, NUDC_PSEA8;  
Q02KW6, NUDC_PSEAB;  O86062, NUDC_PSEAE;  Q1IBF8, NUDC_PSEE4;  
Q4KBL2, NUDC_PSEF5;  A5W1F2, NUDC_PSEP1;  Q3KC83, NUDC_PSEPF;  
B0KMR5, NUDC_PSEPG;  Q88FQ8, NUDC_PSEPK;  B1J6H6, NUDC_PSEPW;  
Q882A9, NUDC_PSESM;  Q4ZTN0, NUDC_PSEU2;  A4VLQ5, NUDC_PSEU5;  
B5F1H9, NUDC_SALA4;  Q57H59, NUDC_SALCH;  B5FQL1, NUDC_SALDC;  
B5QYF1, NUDC_SALEP;  B5RFI8, NUDC_SALG2;  B4TCT5, NUDC_SALHS;  
B4T0Z8, NUDC_SALNS;  Q5PKA4, NUDC_SALPA;  A9N0K8, NUDC_SALPB;  
C0Q2S8, NUDC_SALPC;  B5BJR5, NUDC_SALPK;  B4TQK6, NUDC_SALSV;  
Q8Z328, NUDC_SALTI;  Q9L9I5, NUDC_SALTY;  B2TWI3, NUDC_SHIB3;  
Q31U01, NUDC_SHIBS;  Q32AG9, NUDC_SHIDS;  Q0SY04, NUDC_SHIF8;  
Q83IS3, NUDC_SHIFL;  Q3YUY8, NUDC_SHISS;  B7VM66, NUDC_VIBA3;  
A5F3M9, NUDC_VIBC3;  Q9KV27, NUDC_VIBCH;  C3LR63, NUDC_VIBCM;  
Q87KQ7, NUDC_VIBPA;  Q8DD17, NUDC_VIBVU;  A1JIJ0, NUDC_YERE8;  
A7FNH4, NUDC_YERP3;  Q1C1V1, NUDC_YERPA;  B2K122, NUDC_YERPB;  
Q8ZAQ5, NUDC_YERPE;  A9R8D3, NUDC_YERPG;  Q1CN68, NUDC_YERPN;  
A4TS22, NUDC_YERPP;  Q66FP3, NUDC_YERPS;  B1JJK8, NUDC_YERPY;  
Q9CA40, NUDT1_ARATH;  Q94B74, NUDT2_ARATH;  Q9LE73, NUDT4_ARATH;  
Q9SJC4, NUDT6_ARATH;  Q9SU14, NUDT7_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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