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ENZYME

ENZYME entry: EC 3.6.1.22

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.22
Accepted Name
NAD(+) diphosphatase
Alternative Name(s)
NADH pyrophosphatase
NADP pyrophosphatase
nicotinamide adenine dinucleotide pyrophosphatase
Reaction catalysed
  • NAD(+) + H2O = beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)
  • NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)
Comment(s)
  • This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences.
  • Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogs of NAD(+) and NADP(+).
Cross-references
BRENDA3.6.1.22
EC2PDB3.6.1.22
ExplorEnz3.6.1.22
KEGG Ligand Database for Enzyme Nomenclature3.6.1.22
IUBMB Enzyme Nomenclature3.6.1.22
MEDLINEFind literature relating to 3.6.1.22
MetaCyc3.6.1.22
Rhea expert-curated reactions3.6.1.22
UniProtKB/Swiss-Prot
Q626I0, FAD1_CAEBRQ68EH8, FAD1_DANREQ8NFF5, FAD1_HUMAN
A0A1U8CC89, FAD1_MESAUQ8R123, FAD1_MOUSEQ5RCH4, FAD1_PONAB
D4A4P4, FAD1_RATQ6ING7, FLAD1_XENLAD9YT79, NPP1_WHEAT
Q19427, NPY1_CAEELQ9Y7J0, NPY1_SCHPOP53164, NPY1_YEAST
Q6NPD7, NUD10_ARATHQ29RH3, NUD12_BOVINQ9BQG2, NUD12_HUMAN
Q4R7L8, NUD12_MACFAQ9DCN1, NUD12_MOUSEQ5RD76, NUD12_PONAB
Q86X67, NUD13_HUMANQ8JZU0, NUD13_MOUSEQ94A82, NUD19_ARATH
A6VQT1, NUDC_ACTSZQ7NTZ8, NUDC_CHRVOA8AKS7, NUDC_CITK8
A7MJ81, NUDC_CROS8Q9RV62, NUDC_DEIRAA7ZUL1, NUDC_ECO24
B7UPF1, NUDC_ECO27B7MIY2, NUDC_ECO45B7LA85, NUDC_ECO55
Q8X6X7, NUDC_ECO57B5Z092, NUDC_ECO5EB7NRS9, NUDC_ECO7I
B7N2J8, NUDC_ECO81B7M7Q5, NUDC_ECO8AC5A0T7, NUDC_ECOBW
B1XBZ9, NUDC_ECODHA8A796, NUDC_ECOHSA1AIG7, NUDC_ECOK1
Q0TA69, NUDC_ECOL5Q8FB75, NUDC_ECOL6B1IUQ1, NUDC_ECOLC
P32664, NUDC_ECOLIB7NFT7, NUDC_ECOLUB6I5K7, NUDC_ECOSE
B1LNU8, NUDC_ECOSMQ1R5W2, NUDC_ECOUTC5BHE7, NUDC_EDWI9
A4W5B9, NUDC_ENT38B2VG76, NUDC_ERWT9B7LUK6, NUDC_ESCF3
Q4QNB3, NUDC_HAEI8A5UA57, NUDC_HAEIEA5UGU3, NUDC_HAEIG
P44710, NUDC_HAEINA6TGQ3, NUDC_KLEP7B5XYE2, NUDC_KLEV3
Q65W71, NUDC_MANSMQ7TX14, NUDC_MYCBOA1KNJ7, NUDC_MYCBP
C1AGW8, NUDC_MYCBTA5U7L9, NUDC_MYCTAP9WIX4, NUDC_MYCTO
P9WIX5, NUDC_MYCTUP57965, NUDC_PASMUQ6DAL8, NUDC_PECAS
C6DHS8, NUDC_PECCPQ7N961, NUDC_PHOLLQ6LLW5, NUDC_PHOPR
Q48IH8, NUDC_PSE14B7VB54, NUDC_PSEA8Q02KW6, NUDC_PSEAB
O86062, NUDC_PSEAEQ1IBF8, NUDC_PSEE4Q4KBL2, NUDC_PSEF5
A5W1F2, NUDC_PSEP1A6V6Z8, NUDC_PSEP7Q3KC83, NUDC_PSEPF
B0KMR5, NUDC_PSEPGQ88FQ8, NUDC_PSEPKB1J6H6, NUDC_PSEPW
Q882A9, NUDC_PSESMQ4ZTN0, NUDC_PSEU2B5F1H9, NUDC_SALA4
Q57H59, NUDC_SALCHB5FQL1, NUDC_SALDCB5QYF1, NUDC_SALEP
B5RFI8, NUDC_SALG2B4TCT5, NUDC_SALHSB4T0Z8, NUDC_SALNS
Q5PKA4, NUDC_SALPAA9N0K8, NUDC_SALPBC0Q2S8, NUDC_SALPC
B5BJR5, NUDC_SALPKB4TQK6, NUDC_SALSVQ8Z328, NUDC_SALTI
Q9L9I5, NUDC_SALTYB2TWI3, NUDC_SHIB3Q31U01, NUDC_SHIBS
Q32AG9, NUDC_SHIDSQ0SY04, NUDC_SHIF8Q83IS3, NUDC_SHIFL
Q3YUY8, NUDC_SHISSA4VLQ5, NUDC_STUS1B7VM66, NUDC_VIBA3
A5F3M9, NUDC_VIBC3Q9KV27, NUDC_VIBCHC3LR63, NUDC_VIBCM
Q87KQ7, NUDC_VIBPAQ8DD17, NUDC_VIBVUA1JIJ0, NUDC_YERE8
A7FNH4, NUDC_YERP3Q1C1V1, NUDC_YERPAB2K122, NUDC_YERPB
Q8ZAQ5, NUDC_YERPEA9R8D3, NUDC_YERPGQ1CN68, NUDC_YERPN
A4TS22, NUDC_YERPPQ66FP3, NUDC_YERPSB1JJK8, NUDC_YERPY
Q9CA40, NUDT1_ARATHQ94B74, NUDT2_ARATHQ9LE73, NUDT4_ARATH
Q9SJC4, NUDT6_ARATHP53370, NUDT6_HUMANQ8CH40, NUDT6_MOUSE
P70563, NUDT6_RATQ9SU14, NUDT7_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-