ENZYME entry: EC 3.6.1.40

Accepted Name

guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Alternative Name(s)

guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

guanosine pentaphosphate phosphohydrolase

pppGpp 5'-phosphohydrolase

Reaction catalysed

guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate + H(+)

Comment(s)

Also hydrolyzes other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate,3'-diphosphate.

Cross-references

BRENDA

3.6.1.40

EC2PDB

3.6.1.40

ExplorEnz

3.6.1.40

PRIAM enzyme-specific profiles

3.6.1.40

KEGG Ligand Database for Enzyme Nomenclature

3.6.1.40

IUBMB Enzyme Nomenclature

3.6.1.40

IntEnz

3.6.1.40

MEDLINE

Find literature relating to 3.6.1.40

MetaCyc

3.6.1.40

Rhea expert-curated reactions

3.6.1.40

UniProtKB/Swiss-Prot

A0KEG8, GPPA_AERHH	A4STJ8, GPPA_AERS4	Q5E8U7, GPPA_ALIF1
B5FF86, GPPA_ALIFM	A8ACT2, GPPA_CITK8	A7MQI3, GPPA_CROS8
A7ZTY0, GPPA_ECO24	B7UMN4, GPPA_ECO27	B7MGI9, GPPA_ECO45
B7L8C0, GPPA_ECO55	Q8XAT5, GPPA_ECO57	B5YY27, GPPA_ECO5E
B7NTG3, GPPA_ECO7I	B7N272, GPPA_ECO81	B7M5C6, GPPA_ECO8A
C4ZZ47, GPPA_ECOBW	B1X9Z3, GPPA_ECODH	A8A6N3, GPPA_ECOHS
A1AHU9, GPPA_ECOK1	Q8FBR0, GPPA_ECOL6	B1IWC1, GPPA_ECOLC
P25552, GPPA_ECOLI	B7NF84, GPPA_ECOLU	B6I4B5, GPPA_ECOSE
B1LLV2, GPPA_ECOSM	Q1R4G0, GPPA_ECOUT	A4WG31, GPPA_ENT38
B2VG72, GPPA_ERWT9	B7LU76, GPPA_ESCF3	B5XYZ0, GPPA_KLEP3
A6TGG8, GPPA_KLEP7	Q6CZD8, GPPA_PECAS	C6DHF6, GPPA_PECCP
Q7MYL1, GPPA_PHOLL	Q6LLL4, GPPA_PHOPR	B4F1V2, GPPA_PROMH
Q15N19, GPPA_PSEA6	Q3IDD5, GPPA_PSET1	B5EZ39, GPPA_SALA4
A9MJ30, GPPA_SALAR	Q57HT7, GPPA_SALCH	B5FN73, GPPA_SALDC
B5QVH1, GPPA_SALEP	B5RFS4, GPPA_SALG2	B4TB12, GPPA_SALHS
B4SZ25, GPPA_SALNS	Q5PKK4, GPPA_SALPA	A9MXF2, GPPA_SALPB
C0Q2V8, GPPA_SALPC	B5BIS8, GPPA_SALPK	B4TNT2, GPPA_SALSV
P0A268, GPPA_SALTI	P0A267, GPPA_SALTY	A8G827, GPPA_SERP5
B2TU13, GPPA_SHIB3	Q31UK6, GPPA_SHIBS	Q329V7, GPPA_SHIDS
Q0SYW9, GPPA_SHIF8	Q83PI3, GPPA_SHIFL	Q3YVI5, GPPA_SHISS
Q2NQB1, GPPA_SODGM	B7VMF0, GPPA_VIBA3	A7MXT2, GPPA_VIBC1
A5F3R3, GPPA_VIBC3	Q9KV53, GPPA_VIBCH	C3LQR0, GPPA_VIBCM
Q87KH4, GPPA_VIBPA	Q8DDN5, GPPA_VIBVU	Q7MGP6, GPPA_VIBVY
A1JI66, GPPA_YERE8	A7FD46, GPPA_YERP3	B2K045, GPPA_YERPB
Q74R94, GPPA_YERPE	A9R8H6, GPPA_YERPG	A4TRC9, GPPA_YERPP
Q66G20, GPPA_YERPS	B1JQ12, GPPA_YERPY

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