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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.1.41

Accepted Name
Bis(5'-nucleosyl)-tetraphosphatase (symmetrical).
Alternative Name(s)
Ap(4)A hydrolase.
Ap4A hydrolase.
Diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase.
Diadenosinetetraphosphatase (symmetrical).
Dinucleosidetetraphosphatase (symmetrical).
Reaction catalysed
P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O <=> 2 ADP
Comment(s)
Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl) pentaphosphate, and, more slowly, on some other polyphosphates, forming a nucleoside bisphosphate as one product in all cases (cf. EC 3.6.1.17).
Cross-references
BRENDA3.6.1.41
EC2PDB3.6.1.41
ExplorEnz3.6.1.41
PRIAM enzyme-specific profiles3.6.1.41
KEGG Ligand Database for Enzyme Nomenclature3.6.1.41
IUBMB Enzyme Nomenclature3.6.1.41
IntEnz3.6.1.41
MEDLINEFind literature relating to 3.6.1.41
MetaCyc3.6.1.41
UniProtKB/Swiss-Prot
A1TLA3, APAH_ACIAC;  B9MFH8, APAH_ACIET;  A1W551, APAH_ACISJ;  
A3N0C2, APAH_ACTP2;  B3GXJ7, APAH_ACTP7;  B0BP40, APAH_ACTPJ;  
A6VMA9, APAH_ACTSZ;  A0KGT6, APAH_AERHH;  A4SR08, APAH_AERS4;  
O52655, APAH_AGGAC;  Q5E866, APAH_ALIF1;  B5FGG4, APAH_ALIFM;  
B6EL47, APAH_ALISL;  Q0AC59, APAH_ALKEH;  Q5P6P9, APAH_AROAE;  
C1DIX1, APAH_AZOVD;  Q1LSS3, APAH_BAUCH;  Q7WF80, APAH_BORBR;  
Q7W3V0, APAH_BORPA;  A9I1T6, APAH_BORPD;  Q7W041, APAH_BORPE;  
B8D8U3, APAH_BUCA5;  P57242, APAH_BUCAI;  Q8K9Z9, APAH_BUCAP;  
B8D747, APAH_BUCAT;  Q89AV3, APAH_BUCBP;  A3MMA4, APAH_BURM7;  
A2S9T5, APAH_BURM9;  Q9AEV8, APAH_BURMA;  A1V209, APAH_BURMS;  
A3NYF9, APAH_BURP0;  Q3JPG7, APAH_BURP1;  I1WGA2, APAH_BURP2;  
A3NCP7, APAH_BURP6;  P0DMK2, APAH_BURPS;  Q2SYI5, APAH_BURTA;  
B3PKV6, APAH_CELJU;  Q1QZ29, APAH_CHRSD;  Q7NQS0, APAH_CHRVO;  
A8ALQ2, APAH_CITK8;  Q47VJ7, APAH_COLP3;  B6J646, APAH_COXB1;  
B6J3B1, APAH_COXB2;  A9KH04, APAH_COXBN;  A9N9I1, APAH_COXBR;  
Q83AB7, APAH_COXBU;  A7MIB2, APAH_CROS8;  Q478S1, APAH_DECAR;  
A9BVD2, APAH_DELAS;  A7ZHE2, APAH_ECO24;  B7UI97, APAH_ECO27;  
B7MAH4, APAH_ECO45;  B7L4H2, APAH_ECO55;  Q8XA15, APAH_ECO57;  
B5YZ87, APAH_ECO5E;  B7NHF5, APAH_ECO7I;  B7MNQ8, APAH_ECO81;  
B7M0E6, APAH_ECO8A;  C4ZPX5, APAH_ECOBW;  B1XC50, APAH_ECODH;  
A7ZW01, APAH_ECOHS;  A1A798, APAH_ECOK1;  Q0TLT8, APAH_ECOL5;  
Q8FL98, APAH_ECOL6;  B1IRC7, APAH_ECOLC;  P05637, APAH_ECOLI;  
B7N7S4, APAH_ECOLU;  B6HZ30, APAH_ECOSE;  B1LFY5, APAH_ECOSM;  
Q1RGE8, APAH_ECOUT;  C5B7N9, APAH_EDWI9;  A4W6F5, APAH_ENT38;  
B2VGQ8, APAH_ERWT9;  B7LVU3, APAH_ESCF3;  Q7VLX9, APAH_HAEDU;  
Q4QMZ7, APAH_HAEI8;  A5U9U1, APAH_HAEIE;  A5UH58, APAH_HAEIG;  
P44751, APAH_HAEIN;  B8F4P0, APAH_HAEPS;  Q0I5C4, APAH_HAES1;  
C4K4K8, APAH_HAMD5;  A4G8L5, APAH_HERAR;  B0URM8, APAH_HISS2;  
A6T287, APAH_JANMA;  P27510, APAH_KLEAE;  B5Y1Z6, APAH_KLEP3;  
A6T4I5, APAH_KLEP7;  Q5X0V3, APAH_LEGPA;  A5IIB8, APAH_LEGPC;  
Q5ZRF6, APAH_LEGPH;  Q5WSM5, APAH_LEGPL;  Q65UX2, APAH_MANSM;  
A6VU51, APAH_MARMS;  Q60CE9, APAH_METCA;  Q1H450, APAH_METFK;  
Q5FA03, APAH_NEIG1;  B4RJQ3, APAH_NEIG2;  Q9JVF4, APAH_NEIMA;  
Q82WQ0, APAH_NITEU;  Q2YCK7, APAH_NITMU;  Q3JBF6, APAH_NITOC;  
B2JFC8, APAH_PARP8;  P57922, APAH_PASMU;  Q6D0D8, APAH_PECAS;  
C6DEY8, APAH_PECCP;  Q7N8V9, APAH_PHOLL;  Q6LV43, APAH_PHOPR;  
B4F2I4, APAH_PROMH;  Q48NT9, APAH_PSE14;  A6UZ94, APAH_PSEA7;  
B7V4H6, APAH_PSEA8;  Q02TH3, APAH_PSEAB;  Q9I5U7, APAH_PSEAE;  
Q1IG22, APAH_PSEE4;  Q4K4X3, APAH_PSEF5;  C3K329, APAH_PSEFS;  
A4XZJ6, APAH_PSEMY;  A5VXJ3, APAH_PSEP1;  Q3K5T0, APAH_PSEPF;  
B0KJ91, APAH_PSEPG;  Q88QT8, APAH_PSEPK;  B1JE09, APAH_PSEPW;  
Q88A48, APAH_PSESM;  Q4ZMG3, APAH_PSEU2;  A4VHH8, APAH_PSEU5;  
A1STS0, APAH_PSYIN;  Q8Y1K9, APAH_RALSO;  Q21MT2, APAH_SACD2;  
B5F769, APAH_SALA4;  A9MQG4, APAH_SALAR;  Q57TH2, APAH_SALCH;  
B5FI32, APAH_SALDC;  B5R1S6, APAH_SALEP;  B5RGC0, APAH_SALG2;  
B4TJ45, APAH_SALHS;  B4T6L4, APAH_SALNS;  Q5PDE1, APAH_SALPA;  
A9MYM2, APAH_SALPB;  C0Q5E5, APAH_SALPC;  B5BL25, APAH_SALPK;  
B4TWT4, APAH_SALSV;  P0A1B2, APAH_SALTI;  P0A1B1, APAH_SALTY;  
A8G9N8, APAH_SERP5;  B8EB37, APAH_SHEB2;  A3D186, APAH_SHEB5;  
A6WK57, APAH_SHEB8;  A9L436, APAH_SHEB9;  Q07YJ6, APAH_SHEFN;  
A3QBA1, APAH_SHELP;  Q8EB91, APAH_SHEON;  A4Y433, APAH_SHEPC;  
A0L066, APAH_SHESA;  A8FRV0, APAH_SHESH;  Q0HLT4, APAH_SHESM;  
Q0HS04, APAH_SHESR;  A1RMV0, APAH_SHESW;  B2U257, APAH_SHIB3;  
Q326I4, APAH_SHIBS;  Q32K45, APAH_SHIDS;  Q0T8E6, APAH_SHIF8;  
Q83SQ2, APAH_SHIFL;  Q3Z5W0, APAH_SHISS;  Q2NVX8, APAH_SODGM;  
C5BPC0, APAH_TERTT;  Q3SMC6, APAH_THIDA;  B8GMY8, APAH_THISH;  
C4L9L6, APAH_TOLAT;  A5F8N0, APAH_VIBC3;  A7N0G6, APAH_VIBCB;  
Q9KUS4, APAH_VIBCH;  C3LRH2, APAH_VIBCM;  Q87ST8, APAH_VIBPA;  
Q8DED0, APAH_VIBVU;  Q7MP88, APAH_VIBVY;  Q8D3I0, APAH_WIGBR;  
Q8PP27, APAH_XANAC;  Q3BX84, APAH_XANC5;  Q8PCE5, APAH_XANCP;  
Q2NZI2, APAH_XANOM;  B2SPT1, APAH_XANOP;  Q5GWB7, APAH_XANOR;  
B2I5R6, APAH_XYLF2;  Q9PBJ4, APAH_XYLFA;  Q87C83, APAH_XYLFT;  
A1JJF2, APAH_YERE8;  A7FMC3, APAH_YERP3;  Q1C0H7, APAH_YERPA;  
B2K485, APAH_YERPB;  Q8ZIK7, APAH_YERPE;  A9QZZ2, APAH_YERPG;  
Q1CMT4, APAH_YERPN;  A4TQE0, APAH_YERPP;  Q66ER0, APAH_YERPS;  
B1JKY5, APAH_YERPY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-