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ENZYME entry: EC 3.6.1.45

Accepted Name
UDP-sugar diphosphatase.
Alternative Name(s)
Nucleosidediphosphate-sugar diphosphatase.
Nucleosidediphosphate-sugar pyrophosphatase.
UDP-sugar hydrolase.
UDP-sugar pyrophosphatase.
Reaction catalysed
UDP-sugar + H(2)O <=> UMP + alpha-D-aldose 1-phosphate
Cofactor(s)
Divalent cation.
Comment(s)
  • UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities.
  • Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21.
  • Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
Cross-references
PROSITEPDOC00627
BRENDA3.6.1.45
EC2PDB3.6.1.45
ExplorEnz3.6.1.45
PRIAM enzyme-specific profiles3.6.1.45
KEGG Ligand Database for Enzyme Nomenclature3.6.1.45
IUBMB Enzyme Nomenclature3.6.1.45
IntEnz3.6.1.45
MEDLINEFind literature relating to 3.6.1.45
MetaCyc3.6.1.45
Rhea expert-curated reactions3.6.1.45
UniProtKB/Swiss-Prot
Q9XZ43, 5NTD_LUTLO;  P52307, 5NTD_RHIMP;  Q05B60, NUD14_BOVIN;  
O95848, NUD14_HUMAN;  Q9D142, NUD14_MOUSE;  Q2TBI8, NUD22_BOVIN;  
Q9BRQ3, NUD22_HUMAN;  Q9DD16, NUD22_MOUSE;  Q6P9U1, NUD22_RAT;  
P07024, USHA_ECOLI;  Q9RN37, USHA_SALPU;  Q56878, USHA_YERE8;  

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