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ENZYME entry: EC 3.6.1.5

Accepted Name
Apyrase.
Alternative Name(s)
Adenosine diphosphatase.
ADPase.
ATP-diphosphatase.
ATP-diphosphohydrolase.
Reaction catalysed
A nucleoside 5'-triphosphate + 2 H(2)O <=> a nucleoside 5'-phosphate + 2 phosphate
Cofactor(s)
Ca(2+).
Comment(s)
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
Cross-references
PROSITEPDOC00952
BRENDA3.6.1.5
EC2PDB3.6.1.5
ExplorEnz3.6.1.5
PRIAM enzyme-specific profiles3.6.1.5
KEGG Ligand Database for Enzyme Nomenclature3.6.1.5
IUBMB Enzyme Nomenclature3.6.1.5
IntEnz3.6.1.5
MEDLINEFind literature relating to 3.6.1.5
MetaCyc3.6.1.5
Rhea expert-curated reactions3.6.1.5
UniProtKB/Swiss-Prot
Q9SQG2, APY1_ARATH;  Q8H7L6, APY1_ORYSJ;  Q9SPM5, APY2_ARATH;  
Q6Z4P2, APY2_ORYSJ;  Q9XI62, APY3_ARATH;  Q2QYE1, APY3_ORYSJ;  
Q8H1D8, APY4_ARATH;  Q6NQA8, APY5_ARATH;  O80612, APY6_ARATH;  
F4JSH1, APY7_ARATH;  P50635, APY_AEDAE;  E0D877, APY_AEDAL;  
O96559, APY_CIMLE;  P80595, APY_SOLTU;  B3A0N5, APY_TABYA;  
O18956, ENTP1_BOVIN;  P49961, ENTP1_HUMAN;  P55772, ENTP1_MOUSE;  
Q9MYU4, ENTP1_PIG;  P97687, ENTP1_RAT;  O75355, ENTP3_HUMAN;  
Q8BFW6, ENTP3_MOUSE;  A0JND9, ENTP8_BOVIN;  O93295, ENTP8_CHICK;  
Q5MY95, ENTP8_HUMAN;  Q8K0L2, ENTP8_MOUSE;  Q5DRK1, ENTP8_RAT;  
Q9USP2, YND1_SCHPO;  P40009, YND1_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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