A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.6.1.5
| Accepted Name |
|---|
| Apyrase.
|
| Alternative Name(s) |
|---|
| Adenosine diphosphatase. |
| ADPase. |
| ATP-diphosphatase. |
| ATP-diphosphohydrolase. |
| Reaction catalysed |
|---|
| A nucleoside 5'-triphosphate + 2 H(2)O <=> a nucleoside 5'-phosphate + 2 phosphate |
| Cofactor(s) |
|---|
| Ca(2+).
|
| Comment(s) |
|---|
- Apyrases are active against both di- and triphosphate nucleotides
(NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates
(NMPs) in two distinct successive phosphate-releasing steps, with
NDPs as intermediates.
- They differ from ATPases, which specifically hydrolyze ATP,
by hydrolyzing both ATP and ADP.
- Most of the ecto-ATPases that occur on the cell surface and hydrolyze
extracellular nucleotides belong to this enzyme family.
|
| Cross-references |
|---|
| PROSITE | PDOC00952 |
| BRENDA | 3.6.1.5 |
| EC2PDB | 3.6.1.5 |
| ExplorEnz | 3.6.1.5 |
| PRIAM enzyme-specific profiles | 3.6.1.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.5 |
| IUBMB Enzyme Nomenclature | 3.6.1.5 |
| IntEnz | 3.6.1.5 |
| MEDLINE | Find literature relating to 3.6.1.5 |
| MetaCyc | 3.6.1.5 |
| UniProtKB/Swiss-Prot |
| Q9SQG2, APY1_ARATH; | Q8H7L6, APY1_ORYSJ; | Q9SPM5, APY2_ARATH; |
| Q6Z4P2, APY2_ORYSJ; | Q9XI62, APY3_ARATH; | Q2QYE1, APY3_ORYSJ; |
| Q8H1D8, APY4_ARATH; | Q6NQA8, APY5_ARATH; | O80612, APY6_ARATH; |
| F4JSH1, APY7_ARATH; | P50635, APY_AEDAE; | E0D877, APY_AEDAL; |
| O96559, APY_CIMLE; | P80595, APY_SOLTU; | B3A0N5, APY_TABYA; |
| O18956, ENTP1_BOVIN; | P49961, ENTP1_HUMAN; | P55772, ENTP1_MOUSE; |
| Q9MYU4, ENTP1_PIG; | P97687, ENTP1_RAT; | O75355, ENTP3_HUMAN; |
| A0JND9, ENTP8_BOVIN; | O93295, ENTP8_CHICK; | Q5MY95, ENTP8_HUMAN; |
| Q8K0L2, ENTP8_MOUSE; | Q5DRK1, ENTP8_RAT; | Q9USP2, YND1_SCHPO; |
| P40009, YND1_YEAST; |
|
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