ID 3.6.1.58 DE 8-oxo-dGDP phosphatase. CA (1) 8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate. CA (2) 8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate. CC -!- The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP CC thereby preventing translational errors caused by oxidative damage. CC -!- The preferred in vivo substrate is not known. CC -!- The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the CC monophosphates (cf. EC 3.6.1.55). CC -!- Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are CC hydrolyzed with broad specificity. CC -!- The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and CC D-ribose 5-phosphate (cf. EC 3.6.1.13). CC -!- The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- CC dADP, the latter at a slower rate. DR I6X235, ADPP_MYCTU ; A0QUZ2, MUTT1_MYCS2; Q568Q0, NUD18_DANRE; DR Q6ZVK8, NUD18_HUMAN; Q3U2V3, NUD18_MOUSE; Q641Y7, NUD18_RAT ; DR Q9UKK9, NUDT5_HUMAN; Q9JKX6, NUDT5_MOUSE; Q5RCY2, NUDT5_PONAB; DR Q6AY63, NUDT5_RAT ; //