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ENZYME

ENZYME entry: EC 3.6.1.5

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.5
Accepted Name
apyrase
Alternative Name(s)
adenosine diphosphatase
ADPase
ATP-diphosphatase
ATP-diphosphohydrolase
Reaction catalysed
a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H(+)
Comment(s)
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
Cross-references
BRENDA3.6.1.5
EC2PDB3.6.1.5
ExplorEnz3.6.1.5
KEGG Ligand Database for Enzyme Nomenclature3.6.1.5
IUBMB Enzyme Nomenclature3.6.1.5
MEDLINEFind literature relating to 3.6.1.5
MetaCyc3.6.1.5
Rhea expert-curated reactions3.6.1.5
UniProtKB/Swiss-Prot
Q9SQG2, APY1_ARATHQ8H7L6, APY1_ORYSJQ9SPM5, APY2_ARATH
Q6Z4P2, APY2_ORYSJQ9XI62, APY3_ARATHQ2QYE1, APY3_ORYSJ
Q8H1D8, APY4_ARATHQ6NQA8, APY5_ARATHO80612, APY6_ARATH
F4JSH1, APY7_ARATHP50635, APY_AEDAEE0D877, APY_AEDAL
Q5TVM9, APY_ANOGAO96559, APY_CIMLEQ95P65, APY_GLOMM
Q06K77, APY_PHLDUQ9GTP7, APY_PHLPPP80595, APY_SOLTU
B3A0N5, APY_TABYAO18956, ENTP1_BOVINP49961, ENTP1_HUMAN
P55772, ENTP1_MOUSEQ9MYU4, ENTP1_PIGP97687, ENTP1_RAT
P79784, ENTP2_CHICKQ9Y5L3, ENTP2_HUMANO55026, ENTP2_MOUSE
O35795, ENTP2_RATO75355, ENTP3_HUMANQ8BFW6, ENTP3_MOUSE
A0JND9, ENTP8_BOVINO93295, ENTP8_CHICKQ5MY95, ENTP8_HUMAN
Q8K0L2, ENTP8_MOUSEQ5DRK1, ENTP8_RATQ9USP2, YND1_SCHPO
P40009, YND1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-