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ENZYME

ENZYME entry: EC 3.6.1.60

Accepted Name
diadenosine hexaphosphate hydrolase (AMP-forming)
Reaction catalysed
  • H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)
  • H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)
Comment(s)
  • A divalent cation is essential for activity.
  • Mn(2+) (2-6 mM) is most effective.
  • The enzyme controls intracellular levels of P(1),P(5)- bis(5'-adenosyl)pentaphosphate and P(1),P(6)- bis(5'-adenosyl)hexaphosphate.
  • Weak activity with P(1),P(4)-bis(5'-adenosyl)tetraphosphate.
  • Marked preference for adenine over guanine nucleotides.
Cross-references
BRENDA3.6.1.60
EC2PDB3.6.1.60
ExplorEnz3.6.1.60
PRIAM enzyme-specific profiles3.6.1.60
KEGG Ligand Database for Enzyme Nomenclature3.6.1.60
IUBMB Enzyme Nomenclature3.6.1.60
IntEnz3.6.1.60
MEDLINEFind literature relating to 3.6.1.60
MetaCyc3.6.1.60
Rhea expert-curated reactions3.6.1.60
UniProtKB/Swiss-Prot
Q99321, DDP1_YEASTQ8NFP7, NUD10_HUMANP0C027, NUD10_MOUSE
Q58CW0, NUD11_BOVINQ96G61, NUD11_HUMANP0C028, NUD11_MOUSE

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