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ENZYME entry: EC 3.6.1.62

Accepted Name
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Alternative Name(s)
M(7)GpppN-mRNA hydrolase.
Reaction catalysed
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O <=> N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA]
Comment(s)
  • Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
  • The enzyme is unable to cleave a free cap structure (m(7)GpppG).
  • The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+).
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.62
EC2PDB3.6.1.62
ExplorEnz3.6.1.62
PRIAM enzyme-specific profiles3.6.1.62
KEGG Ligand Database for Enzyme Nomenclature3.6.1.62
IUBMB Enzyme Nomenclature3.6.1.62
IntEnz3.6.1.62
MEDLINEFind literature relating to 3.6.1.62
MetaCyc3.6.1.62
UniProtKB/Swiss-Prot
Q8GW31, DCP2_ARATH;  Q8IU60, DCP2_HUMAN;  Q9CYC6, DCP2_MOUSE;  
Q5REQ8, DCP2_PONAB;  P53550, DCP2_YEAST;  A1A4Q9, NUD16_BOVIN;  
P0DKY8, NUD16_HOMVI;  Q96DE0, NUD16_HUMAN;  Q6P3D0, NUD16_MOUSE;  
Q2V8X7, NUD16_SHEEP;  Q6TEC1, NUD16_XENLA;  

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