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ENZYME

ENZYME entry: EC 3.6.1.62

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.62
Accepted Name
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase
Alternative Name(s)
m(7)GpppN-mRNA hydrolase
Reaction catalysed
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)
Comment(s)
  • Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
  • The enzyme is unable to cleave a free cap structure (m(7)GpppG).
  • The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+).
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.62
EC2PDB3.6.1.62
ExplorEnz3.6.1.62
KEGG Ligand Database for Enzyme Nomenclature3.6.1.62
IUBMB Enzyme Nomenclature3.6.1.62
MEDLINEFind literature relating to 3.6.1.62
MetaCyc3.6.1.62
Rhea expert-curated reactions3.6.1.62
UniProtKB/Swiss-Prot
Q9NPI6, DCP1A_HUMANQ91YD3, DCP1A_MOUSEI3LHS8, DCP1A_PIG
Q3SZL6, DCP1B_BOVINQ8IZD4, DCP1B_HUMANQ3U564, DCP1B_MOUSE
Q5R413, DCP1B_PONABQ8GW31, DCP2_ARATHO62255, DCP2_CAEEL
Q8IU60, DCP2_HUMANQ9CYC6, DCP2_MOUSEQ5REQ8, DCP2_PONAB
P53550, DCP2_YEASTQ583R7, NDX4_TRYB2A1A4Q9, NUD16_BOVIN
P0DKY8, NUD16_HOMVIQ96DE0, NUD16_HUMANQ6P3D0, NUD16_MOUSE
Q2V8X7, NUD16_SHEEPQ6TEC1, NUD16_XENLAA4FUG7, NUD17_BOVIN
Q4V8V2, NUD17_DANREP0C025, NUD17_HUMANQ9CWD3, NUD17_MOUSE
Q5PQ04, NUD17_XENLAQ5M8V2, NUD17_XENTRA2VE79, NUDT3_BOVIN
O95989, NUDT3_HUMANQ9JI46, NUDT3_MOUSEQ566C7, NUDT3_RAT

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-