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ENZYME entry: EC 3.6.1.62

Accepted Name
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Alternative Name(s)
m(7)GpppN-mRNA hydrolase.
Reaction catalysed
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP
Comment(s)
  • Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
  • The enzyme is unable to cleave a free cap structure (m(7)GpppG).
  • The enzyme from Vaccinia virus is synergistically activated in the presence of Mg(2+) and Mn(2+).
  • Formerly EC 3.6.1.30.
Cross-references
BRENDA3.6.1.62
EC2PDB3.6.1.62
ExplorEnz3.6.1.62
PRIAM enzyme-specific profiles3.6.1.62
KEGG Ligand Database for Enzyme Nomenclature3.6.1.62
IUBMB Enzyme Nomenclature3.6.1.62
IntEnz3.6.1.62
MEDLINEFind literature relating to 3.6.1.62
MetaCyc3.6.1.62
Rhea expert-curated reactions3.6.1.62
UniProtKB/Swiss-Prot
Q9NPI6, DCP1A_HUMAN;  Q91YD3, DCP1A_MOUSE;  I3LHS8, DCP1A_PIG;  
Q3SZL6, DCP1B_BOVIN;  Q8IZD4, DCP1B_HUMAN;  Q3U564, DCP1B_MOUSE;  
Q5R413, DCP1B_PONAB;  Q8GW31, DCP2_ARATH;  O62255, DCP2_CAEEL;  
Q8IU60, DCP2_HUMAN;  Q9CYC6, DCP2_MOUSE;  Q5REQ8, DCP2_PONAB;  
P53550, DCP2_YEAST;  A1A4Q9, NUD16_BOVIN;  P0DKY8, NUD16_HOMVI;  
Q96DE0, NUD16_HUMAN;  Q6P3D0, NUD16_MOUSE;  Q2V8X7, NUD16_SHEEP;  
Q6TEC1, NUD16_XENLA;  

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