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ENZYME entry: EC 3.6.1.62
Accepted Name |
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
|
Alternative Name(s) |
m(7)GpppN-mRNA hydrolase. |
Reaction catalysed |
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP |
Comment(s) |
- Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
- The enzyme is unable to cleave a free cap structure (m(7)GpppG).
- The enzyme from Vaccinia virus is synergistically activated in the
presence of Mg(2+) and Mn(2+).
- Formerly EC 3.6.1.30.
|
Cross-references |
BRENDA | 3.6.1.62 |
EC2PDB | 3.6.1.62 |
ExplorEnz | 3.6.1.62 |
PRIAM enzyme-specific profiles | 3.6.1.62 |
KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.62 |
IUBMB Enzyme Nomenclature | 3.6.1.62 |
IntEnz | 3.6.1.62 |
MEDLINE | Find literature relating to 3.6.1.62 |
MetaCyc | 3.6.1.62 |
Rhea expert-curated reactions | 3.6.1.62 |
UniProtKB/Swiss-Prot |
Q9NPI6, DCP1A_HUMAN; | Q91YD3, DCP1A_MOUSE; | I3LHS8, DCP1A_PIG; |
Q3SZL6, DCP1B_BOVIN; | Q8IZD4, DCP1B_HUMAN; | Q3U564, DCP1B_MOUSE; |
Q5R413, DCP1B_PONAB; | Q8GW31, DCP2_ARATH; | O62255, DCP2_CAEEL; |
Q8IU60, DCP2_HUMAN; | Q9CYC6, DCP2_MOUSE; | Q5REQ8, DCP2_PONAB; |
P53550, DCP2_YEAST; | A1A4Q9, NUD16_BOVIN; | P0DKY8, NUD16_HOMVI; |
Q96DE0, NUD16_HUMAN; | Q6P3D0, NUD16_MOUSE; | Q2V8X7, NUD16_SHEEP; |
Q6TEC1, NUD16_XENLA; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
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