A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.6.1.62
Accepted Name |
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
|
Alternative Name(s) |
M(7)GpppN-mRNA hydrolase. |
Reaction catalysed |
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O <=> N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA] |
Comment(s) |
- Decapping of mRNA is a critical step in eukaryotic mRNA turnover.
- The enzyme is unable to cleave a free cap structure (m(7)GpppG).
- The enzyme from Vaccinia virus is synergistically activated in the
presence of Mg(2+) and Mn(2+).
- Formerly EC 3.6.1.30.
|
Cross-references |
BRENDA | 3.6.1.62 |
EC2PDB | 3.6.1.62 |
ExplorEnz | 3.6.1.62 |
PRIAM enzyme-specific profiles | 3.6.1.62 |
KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.62 |
IUBMB Enzyme Nomenclature | 3.6.1.62 |
IntEnz | 3.6.1.62 |
MEDLINE | Find literature relating to 3.6.1.62 |
MetaCyc | 3.6.1.62 |
UniProtKB/Swiss-Prot |
Q8GW31, DCP2_ARATH; | Q8IU60, DCP2_HUMAN; | Q9CYC6, DCP2_MOUSE; |
Q5REQ8, DCP2_PONAB; | P53550, DCP2_YEAST; | A1A4Q9, NUD16_BOVIN; |
P0DKY8, NUD16_HOMVI; | Q96DE0, NUD16_HUMAN; | Q6P3D0, NUD16_MOUSE; |
Q2V8X7, NUD16_SHEEP; | Q6TEC1, NUD16_XENLA; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-