ID   3.6.1.71
DE   adenosine-5'-diphospho-5'-[DNA] diphosphatase.
AN   5'-App5'-DNA adenylate hydrolase.
AN   aprataxin.
CA   (1) a 5'-end adenosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA +
CA   H2O = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+).
CA   (2) a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-
CA   2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-monophospho-
CA   ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+).
CC   -!- Aprataxin is a DNA-binding protein involved in different types of DNA
CC       break repair.
CC   -!- The enzyme acts (among other activities) on abortive DNA ligation
CC       intermediates that contain an adenylate covalently linked to the
CC       5'-phosphate DNA terminus.
CC   -!- It also acts when the adenylate is covalently linked to the
CC       5'-phosphate of a ribonucleotide linked to a DNA strand, which is the
CC       result of abortive ligase activty on products of EC 3.1.26.4,
CC       an enzyme that cleaves RNA-DNA hybrids on the 5' side of the
CC       ribonucleotide found in the 5'-RNA-DNA-3' junction.
CC   -!- Aprataxin binds the adenylate group to a histidine residue within the
CC       active site, followed by its hydrolysis from the nucleic acid and
CC       eventual release, leaving a 5'-phosphate terminus that can be
CC       efficiently rejoined.
CC   -!- The enzyme also possesses the activities of EC 3.6.1.70 and
CC       EC 3.6.1.72.
CC   -!- Formerly EC 3.1.11.7.
DR   Q7YRZ2, APTX_BOVIN ;  P61797, APTX_CANLF ;  P61798, APTX_CHICK ;
DR   P61802, APTX_CIOIN ;  P61799, APTX_DANRE ;  Q7Z2E3, APTX_HUMAN ;
DR   Q9BGQ0, APTX_MACFA ;  Q7TQC5, APTX_MOUSE ;  Q7YRZ1, APTX_PIG   ;
DR   Q8K4H4, APTX_RAT   ;  O74859, APTX_SCHPO ;  P61800, APTX_TAKRU ;
DR   Q7T287, APTX_XENLA ;  P61801, APTX_XENTR ;  Q08702, APTX_YEAST ;
//