ID 3.6.1.72 DE DNA-3'-diphospho-5'-guanosine diphosphatase. AN aprataxin. AN DNA-3'pp5'G guanylate hydrolase. CA a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = CA a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+). CC -!- Aprataxin is a DNA-binding protein that catalyzes (among other CC activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8). CC -!- The enzyme binds the guanylate group to a histidine residue at its CC active site, forming a covalent enzyme-nucleotide phosphate CC intermediate, followed by the hydrolysis of the guanylate from the CC nucleic acid and its eventual release. CC -!- The enzyme also possesses the activity of EC 3.6.1.71 and CC EC 3.6.1.72. CC -!- Formerly EC 3.1.12.2. DR Q7YRZ2, APTX_BOVIN ; P61797, APTX_CANLF ; P61798, APTX_CHICK ; DR P61802, APTX_CIOIN ; P61799, APTX_DANRE ; Q7Z2E3, APTX_HUMAN ; DR Q9BGQ0, APTX_MACFA ; Q7TQC5, APTX_MOUSE ; Q7YRZ1, APTX_PIG ; DR Q8K4H4, APTX_RAT ; O74859, APTX_SCHPO ; P61800, APTX_TAKRU ; DR Q7T287, APTX_XENLA ; P61801, APTX_XENTR ; Q08702, APTX_YEAST ; //