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ENZYME

ENZYME entry: EC 3.6.1.77

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.77
Accepted Name
coenzyme A diphosphatase
Alternative Name(s)
CoA diphosphohydrolase
CoA pyrophosphatase
coenzyme A pyrophosphatase
Reaction catalysed
CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Comment(s)
  • The enzyme belongs to the Nudix hydrolase family.
  • It has been reported from bacteria, yeast, and mammals.
  • Activity is higher with oxidized disulfide CoA than with reduced CoA.
Cross-references
BRENDA3.6.1.77
EC2PDB3.6.1.77
ExplorEnz3.6.1.77
KEGG Ligand Database for Enzyme Nomenclature3.6.1.77
IUBMB Enzyme Nomenclature3.6.1.77
MEDLINEFind literature relating to 3.6.1.77
MetaCyc3.6.1.77
Rhea expert-curated reactions3.6.1.77
UniProtKB/Swiss-Prot
Q5ZL13, NUD19_CHICKA8MXV4, NUD19_HUMANP11930, NUD19_MOUSE
Q7M0H3, NUD19_MUSCRQ7M0H4, NUD19_MUSSAQ6AYD9, NUD19_RAT
Q5PQ50, NUD19_XENLAP0C024, NUDT7_HUMANQ99P30, NUDT7_MOUSE
Q8WV74, NUDT8_HUMANQ9CR24, NUDT8_MOUSEQ12524, PCD1_YEAST
Q9RV46, Y1184_DEIRA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-