ID   3.6.1.9
DE   nucleotide diphosphatase.
AN   dinucleotide nucleotidohydrolase.
AN   nucleoside-triphosphate diphosphatase.
AN   nucleotide pyrophosphatase.
CA   (1) a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside
CA   5'-phosphate + diphosphate + H(+).
CA   (2) a 2'-deoxyribonucleoside 5'-triphosphate + H2O =
CA   a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+).
CC   -!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze
CC       other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to
CC       their corresponding monophosphates.
CC   -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP,
CC       NAD(+), NADP(+), FAD, and CoA.
CC   -!- Formerly EC 3.6.1.19.
DR   O95671, ASML_HUMAN ;  A0A2L0V161, DGTPH_BPPMB;  A0A7U3TBV3, DGTPH_BPS2L;
DR   A0A2H5BHG5, DGTPH_BPSHA;  P22413, ENPP1_HUMAN;  P06802, ENPP1_MOUSE;
DR   Q924C3, ENPP1_RAT  ;  P15396, ENPP3_BOVIN;  O14638, ENPP3_HUMAN;
DR   Q6DYE8, ENPP3_MOUSE;  Q5R5M5, ENPP3_PONAB;  P97675, ENPP3_RAT  ;
DR   Q9X015, MAZG_THEMA ;  D9YT79, NPP1_WHEAT ;  P25353, NPP1_YEAST ;
DR   A0A3B6EFE3, NPP2_WHEAT ;  P39997, NPP2_YEAST ;  Q8G4U8, NTPNH_BIFLO;
DR   Q28VZ8, NTPP1_JANSC;  Q28NC5, NTPP2_JANSC;  A3DBJ9, NTPPA_ACET2;
DR   A9NE14, NTPPA_ACHLI;  Q6FDX8, NTPPA_ACIAD;  C4ZDP0, NTPPA_AGARV;
DR   Q8UHX5, NTPPA_AGRFC;  B2UPE6, NTPPA_AKKM8;  Q21WP7, NTPPA_ALBFT;
DR   Q0VS67, NTPPA_ALCBS;  Q5E7X6, NTPPA_ALIF1;  Q0ABM5, NTPPA_ALKEH;
DR   A6TQH7, NTPPA_ALKMQ;  A8MHM5, NTPPA_ALKOO;  B8JH92, NTPPA_ANAD2;
DR   Q2IKU4, NTPPA_ANADE;  A7HA27, NTPPA_ANADF;  B4UJ23, NTPPA_ANASK;
DR   O67613, NTPPA_AQUAE;  Q5P2U3, NTPPA_AROAE;  C3P9E0, NTPPA_BACAA;
DR   C3L6Y6, NTPPA_BACAC;  Q81LD6, NTPPA_BACAN;  B7JQ48, NTPPA_BACC0;
DR   Q72ZX1, NTPPA_BACC1;  B7IIW6, NTPPA_BACC2;  C1ETQ1, NTPPA_BACC3;
DR   B7HE87, NTPPA_BACC4;  B7HQL2, NTPPA_BACC7;  A7GTD6, NTPPA_BACCN;
DR   B9IZ30, NTPPA_BACCQ;  Q817R9, NTPPA_BACCR;  Q633Y9, NTPPA_BACCZ;
DR   Q5LAQ8, NTPPA_BACFN;  Q64R56, NTPPA_BACFR;  Q6HD71, NTPPA_BACHK;
DR   Q65GL2, NTPPA_BACLD;  A9VIS9, NTPPA_BACMK;  A8FFU1, NTPPA_BACP2;
DR   Q02169, NTPPA_BACSU;  Q8A749, NTPPA_BACTN;  A7Z794, NTPPA_BACVZ;
DR   Q6G253, NTPPA_BARHE;  Q6G132, NTPPA_BARQU;  Q6MQJ7, NTPPA_BDEBA;
DR   Q2KYV3, NTPPA_BORA1;  Q7WL84, NTPPA_BORBR;  Q7W7U4, NTPPA_BORPA;
DR   Q7VWE3, NTPPA_BORPE;  Q89V00, NTPPA_BRADU;  A5EAG4, NTPPA_BRASB;
DR   Q2YPC2, NTPPA_BRUA2;  Q57FA3, NTPPA_BRUAB;  Q8YF55, NTPPA_BRUME;
DR   Q8G2R6, NTPPA_BRUSU;  Q39E95, NTPPA_BURL3;  Q62II4, NTPPA_BURMA;
DR   Q1BUW3, NTPPA_BURO1;  Q3JUG5, NTPPA_BURP1;  Q63VT5, NTPPA_BURPS;
DR   Q2SZT6, NTPPA_BURTA;  B9MRU6, NTPPA_CALBD;  Q8RBC6, NTPPA_CALS4;
DR   A4XKL5, NTPPA_CALS8;  Q3AF81, NTPPA_CARHZ;  Q9A5V5, NTPPA_CAUVC;
DR   Q3J086, NTPPA_CERS4;  Q11LY4, NTPPA_CHESB;  Q5L6G5, NTPPA_CHLAB;
DR   Q3AQS4, NTPPA_CHLCH;  Q823U1, NTPPA_CHLCV;  Q253S7, NTPPA_CHLFF;
DR   Q3B3P0, NTPPA_CHLL3;  B3QNY9, NTPPA_CHLP8;  A4SE83, NTPPA_CHLPM;
DR   B0B7R8, NTPPA_CHLT2;  Q3KM09, NTPPA_CHLTA;  B0BBY3, NTPPA_CHLTB;
DR   Q8KDS1, NTPPA_CHLTE;  O84353, NTPPA_CHLTR;  A0M2D8, NTPPA_CHRFK;
DR   Q1QVC0, NTPPA_CHRI1;  Q7P1T8, NTPPA_CHRVO;  B5EHR3, NTPPA_CITBB;
DR   Q97JN3, NTPPA_CLOAB;  A7FXW4, NTPPA_CLOB1;  C3L3L1, NTPPA_CLOB6;
DR   A6LQP7, NTPPA_CLOB8;  B2V089, NTPPA_CLOBA;  B2TK54, NTPPA_CLOBB;
DR   A5I684, NTPPA_CLOBH;  C1FVY3, NTPPA_CLOBJ;  B1IM03, NTPPA_CLOBK;
DR   A7GHM0, NTPPA_CLOBL;  B1KZT1, NTPPA_CLOBM;  Q18B07, NTPPA_CLOD6;
DR   B9E003, NTPPA_CLOK1;  A5N6I4, NTPPA_CLOK5;  A0PZG3, NTPPA_CLONN;
DR   Q0TNG7, NTPPA_CLOP1;  Q8XIH4, NTPPA_CLOPE;  Q0SR36, NTPPA_CLOPS;
DR   Q892M0, NTPPA_CLOTE;  Q47VG7, NTPPA_COLP3;  Q1LQB1, NTPPA_CUPMC;
DR   Q46Y94, NTPPA_CUPPJ;  Q11VI6, NTPPA_CYTH3;  Q47JQ0, NTPPA_DECAR;
DR   Q3Z7G4, NTPPA_DEHM1;  A5FQJ4, NTPPA_DEHMB;  Q3ZY38, NTPPA_DEHMC;
DR   Q1IYX1, NTPPA_DEIGD;  Q9RV24, NTPPA_DEIRA;  Q24SM2, NTPPA_DESHY;
DR   Q6AMI5, NTPPA_DESPS;  A4J7K7, NTPPA_DESRM;  B5YF11, NTPPA_DICT6;
DR   B8E0U2, NTPPA_DICTD;  P58629, NTPPA_ECO57;  Q0TCL8, NTPPA_ECOL5;
DR   Q8FD47, NTPPA_ECOL6;  P25536, NTPPA_ECOLI;  Q1R692, NTPPA_ECOUT;
DR   B2KC30, NTPPA_ELUMP;  Q82ZA4, NTPPA_ENTFA;  B1YJT1, NTPPA_EXIS2;
DR   A5FFP4, NTPPA_FLAJ1;  A6GZH5, NTPPA_FLAPJ;  Q8RFE6, NTPPA_FUSNN;
DR   Q5KWN2, NTPPA_GEOKA;  Q39X87, NTPPA_GEOMG;  Q74A46, NTPPA_GEOSL;
DR   C6E559, NTPPA_GEOSM;  C5D5H8, NTPPA_GEOSW;  A5G7S1, NTPPA_GEOUR;
DR   Q7NH22, NTPPA_GLOVI;  Q5FS71, NTPPA_GLUOX;  Q0BTC5, NTPPA_GRABC;
DR   Q2SBH1, NTPPA_HAHCH;  Q9K8H3, NTPPA_HALH5;  Q31FH4, NTPPA_HYDCU;
DR   Q0C2H1, NTPPA_HYPNA;  Q5QWE2, NTPPA_IDILO;  Q1IV55, NTPPA_KORVE;
DR   B3W9W2, NTPPA_LACCB;  Q035Z4, NTPPA_LACP3;  A9KHL6, NTPPA_LACP7;
DR   Q38YR2, NTPPA_LATSS;  Q1MQH1, NTPPA_LAWIP;  B0S919, NTPPA_LEPBA;
DR   Q04NX0, NTPPA_LEPBJ;  Q04XA6, NTPPA_LEPBL;  B0SK44, NTPPA_LEPBP;
DR   Q72WC1, NTPPA_LEPIC;  Q8FA20, NTPPA_LEPIN;  Q0AQL3, NTPPA_MARMM;
DR   Q8TSP7, NTPPA_METAC;  Q46BZ6, NTPPA_METBF;  Q12TU6, NTPPA_METBU;
DR   Q60BT7, NTPPA_METCA;  Q1GZF7, NTPPA_METFK;  Q8PVQ2, NTPPA_METMA;
DR   Q2RL24, NTPPA_MOOTA;  Q1D912, NTPPA_MYXXD;  Q5FA52, NTPPA_NEIG1;
DR   Q9JVK3, NTPPA_NEIMA;  Q9K0J8, NTPPA_NEIMB;  Q82XC7, NTPPA_NITEU;
DR   Q1QRF9, NTPPA_NITHX;  Q2YC50, NTPPA_NITMU;  Q3J7T5, NTPPA_NITOC;
DR   Q72EP2, NTPPA_NITV2;  Q3SVZ7, NTPPA_NITWN;  Q2G9H1, NTPPA_NOVAD;
DR   Q315F5, NTPPA_OLEA2;  A6L8E5, NTPPA_PARD8;  Q2W1Y3, NTPPA_PARM1;
DR   Q6MDL5, NTPPA_PARUW;  Q142M3, NTPPA_PARXL;  Q9CLG6, NTPPA_PASMU;
DR   Q6DAI3, NTPPA_PECAS;  B4SA80, NTPPA_PELPB;  A5D426, NTPPA_PELTS;
DR   Q7N035, NTPPA_PHOLL;  Q6LMA4, NTPPA_PHOPR;  A6L391, NTPPA_PHOV8;
DR   Q12C38, NTPPA_POLSJ;  B2RIL9, NTPPA_PORG3;  Q7MWG0, NTPPA_PORGI;
DR   Q48E97, NTPPA_PSE14;  Q15ZH0, NTPPA_PSEA6;  Q9HVU3, NTPPA_PSEAE;
DR   Q4KIA3, NTPPA_PSEF5;  Q3KI22, NTPPA_PSEPF;  Q88PB4, NTPPA_PSEPK;
DR   Q87WS4, NTPPA_PSESM;  Q3IFH5, NTPPA_PSET1;  Q4ZNT2, NTPPA_PSEU2;
DR   Q4FUF9, NTPPA_PSYA2;  Q1QDI9, NTPPA_PSYCK;  Q9UXZ1, NTPPA_PYRAB;
DR   Q8U476, NTPPA_PYRFU;  O59604, NTPPA_PYRHO;  P58634, NTPPA_RALN1;
DR   Q2KCN4, NTPPA_RHIEC;  Q1MLP2, NTPPA_RHIJ3;  Q989F1, NTPPA_RHILO;
DR   Q92S22, NTPPA_RHIME;  Q7UWY8, NTPPA_RHOBA;  Q2IRX7, NTPPA_RHOP2;
DR   Q6N181, NTPPA_RHOPA;  Q20Y49, NTPPA_RHOPB;  Q130J6, NTPPA_RHOPS;
DR   Q2RQN0, NTPPA_RHORT;  Q169N3, NTPPA_ROSDO;  Q1AVT5, NTPPA_RUBXD;
DR   Q5LLE9, NTPPA_RUEPO;  Q1GLE1, NTPPA_RUEST;  B8I6Q1, NTPPA_RUMCH;
DR   Q21FT3, NTPPA_SACD2;  Q57J97, NTPPA_SALCH;  Q5PJV0, NTPPA_SALPA;
DR   Q2S4I1, NTPPA_SALRD;  P58631, NTPPA_SALTI;  P58630, NTPPA_SALTY;
DR   O14141, NTPPA_SCHPO;  Q12IW9, NTPPA_SHEDO;  Q07WQ2, NTPPA_SHEFN;
DR   Q8EA14, NTPPA_SHEON;  Q0HEI2, NTPPA_SHESM;  Q0HZH0, NTPPA_SHESR;
DR   Q31WB6, NTPPA_SHIBS;  Q32B92, NTPPA_SHIDS;  Q3YX01, NTPPA_SHISS;
DR   Q5WEQ9, NTPPA_SHOC1;  Q1GRU5, NTPPA_SPHAL;  A3DMH6, NTPPA_STAMF;
DR   Q67SI8, NTPPA_SYMTH;  Q2LSD6, NTPPA_SYNAS;  Q3A7I0, NTPPA_SYNC1;
DR   Q0AWG2, NTPPA_SYNWW;  B7IFS5, NTPPA_THEAB;  C5A216, NTPPA_THEGJ;
DR   Q5JI98, NTPPA_THEKO;  A6LJI7, NTPPA_THEM4;  Q9X1P2, NTPPA_THEMA;
DR   B6YWV3, NTPPA_THEON;  A5IM27, NTPPA_THEP1;  B0KAE1, NTPPA_THEP3;
DR   B0K437, NTPPA_THEPX;  B9KXM8, NTPPA_THERP;  B1LB65, NTPPA_THESQ;
DR   Q72JE7, NTPPA_THET2;  Q5SJ26, NTPPA_THET8;  Q3SG65, NTPPA_THIDA;
DR   Q73K74, NTPPA_TREDE;  Q9KUU7, NTPPA_VIBCH;  Q87LC4, NTPPA_VIBPA;
DR   Q8DCG8, NTPPA_VIBVU;  Q7MHE0, NTPPA_VIBVY;  Q73I47, NTPPA_WOLPM;
DR   B3CL80, NTPPA_WOLPP;  Q5GT91, NTPPA_WOLTR;  C0R2U8, NTPPA_WOLWR;
DR   Q8PIX4, NTPPA_XANAC;  Q4UWJ9, NTPPA_XANC8;  Q8P7K1, NTPPA_XANCP;
DR   Q3BRF4, NTPPA_XANE5;  Q2P0P1, NTPPA_XANOM;  Q5GXK1, NTPPA_XANOR;
DR   Q99210, NTPPA_YEAST;  Q1C1M9, NTPPA_YERPA;  P58636, NTPPA_YERPE;
DR   Q1CDV0, NTPPA_YERPN;  Q665F6, NTPPA_YERPS;  Q5NNS3, NTPPA_ZYMMO;
DR   B0C1T2, NTPP_ACAM1 ;  Q6FB05, NTPP_ACIAD ;  Q8UJC6, NTPP_AGRFC ;
DR   B9KIX1, NTPP_ANAMF ;  Q5PAF5, NTPP_ANAMM ;  Q2GKV0, NTPP_ANAPZ ;
DR   Q89WP0, NTPP_BRADU ;  A8FKT3, NTPP_CAMJ8 ;  A7H4N2, NTPP_CAMJD ;
DR   Q9PI04, NTPP_CAMJE ;  A1VYL9, NTPP_CAMJJ ;  Q5HVQ6, NTPP_CAMJR ;
DR   Q9AC58, NTPP_CAUVC ;  Q3IYH0, NTPP_CERS4 ;  Q9PK45, NTPP_CHLMU ;
DR   Q9Z9F9, NTPP_CHLPN ;  C3PEA3, NTPP_CORA7 ;  Q6NIW2, NTPP_CORDI ;
DR   Q8FRM5, NTPP_COREF ;  A4QC50, NTPP_CORGB ;  Q8NSH0, NTPP_CORGL ;
DR   Q4JTL6, NTPP_CORJK ;  Q6A725, NTPP_CUTAK ;  B8HN65, NTPP_CYAP4 ;
DR   B1I4S1, NTPP_DESAP ;  Q55G28, NTPP_DICDI ;  Q3YRV1, NTPP_EHRCJ ;
DR   Q2GGV6, NTPP_EHRCR ;  Q5FGZ7, NTPP_EHRRG ;  Q5HB21, NTPP_EHRRW ;
DR   Q2GCP9, NTPP_EHRS3 ;  B7KJY0, NTPP_GLOC7 ;  Q5FS37, NTPP_GLUOX ;
DR   Q0BWA0, NTPP_GRABC ;  Q7VKR7, NTPP_HAEDU ;  B6JN80, NTPP_HELP2 ;
DR   B5Z8N5, NTPP_HELPG ;  Q1CS23, NTPP_HELPH ;  Q9ZJY6, NTPP_HELPJ ;
DR   B2UV03, NTPP_HELPS ;  O25838, NTPP_HELPY ;  Q0C6A7, NTPP_HYPNA ;
DR   Q5X3L5, NTPP_LEGPA ;  A5IDM1, NTPP_LEGPC ;  Q5ZTX2, NTPP_LEGPH ;
DR   Q5WV03, NTPP_LEGPL ;  Q6AGN3, NTPP_LEIXX ;  Q0AKD7, NTPP_MARMM ;
DR   B0JH94, NTPP_MICAN ;  Q7TWT7, NTPP_MYCBO ;  A1KNT4, NTPP_MYCBP ;
DR   C1AH56, NTPP_MYCBT ;  A4TF31, NTPP_MYCGI ;  B8ZUX8, NTPP_MYCLB ;
DR   Q49670, NTPP_MYCLE ;  B2HEK5, NTPP_MYCMM ;  Q73UG7, NTPP_MYCPA ;
DR   A0QTE5, NTPP_MYCS2 ;  A3PW53, NTPP_MYCSJ ;  A1UCG3, NTPP_MYCSK ;
DR   Q1BCI0, NTPP_MYCSS ;  A5U7V6, NTPP_MYCTA ;  P9WK26, NTPP_MYCTO ;
DR   P9WK27, NTPP_MYCTU ;  A0PRJ3, NTPP_MYCUA ;  A1T5Q3, NTPP_MYCVP ;
DR   Q1DAV2, NTPP_MYXXD ;  Q1QRY3, NTPP_NITHX ;  A6Q573, NTPP_NITSB ;
DR   Q3SWH0, NTPP_NITWN ;  Q5Z154, NTPP_NOCFA ;  B2J6P8, NTPP_NOSP7 ;
DR   P58632, NTPP_NOSS1 ;  Q2GC58, NTPP_NOVAD ;  A5CCC1, NTPP_ORITB ;
DR   Q2VYH3, NTPP_PARM1 ;  Q7U5K1, NTPP_PARMW ;  Q4FNS4, NTPP_PELUB ;
DR   A3PDZ9, NTPP_PROM0 ;  A2C3V6, NTPP_PROM1 ;  A8G5U9, NTPP_PROM2 ;
DR   A2C7X9, NTPP_PROM3 ;  Q319X8, NTPP_PROM9 ;  Q7VB43, NTPP_PROMA ;
DR   Q7V6H8, NTPP_PROMM ;  Q7V0U3, NTPP_PROMP ;  A2BS59, NTPP_PROMS ;
DR   Q46JR8, NTPP_PROMT ;  C0ZWV2, NTPP_RHOE4 ;  Q0S319, NTPP_RHOJR ;
DR   C1B1A6, NTPP_RHOOB ;  Q2J353, NTPP_RHOP2 ;  Q6ND10, NTPP_RHOPA ;
DR   Q21CL6, NTPP_RHOPB ;  Q13E26, NTPP_RHOPS ;  Q2RN87, NTPP_RHORT ;
DR   C3PLU6, NTPP_RICAE ;  A8GQ13, NTPP_RICAH ;  A8GXY9, NTPP_RICB8 ;
DR   Q1RK90, NTPP_RICBR ;  A8F031, NTPP_RICCK ;  Q92G57, NTPP_RICCN ;
DR   Q4UJZ5, NTPP_RICFE ;  Q9ZCE2, NTPP_RICPR ;  C4K258, NTPP_RICPU ;
DR   B0BVE4, NTPP_RICRO ;  A8GTV6, NTPP_RICRS ;  Q68VT4, NTPP_RICTY ;
DR   B7K400, NTPP_RIPO1 ;  Q16CZ1, NTPP_ROSDO ;  Q5LLN0, NTPP_RUEPO ;
DR   Q1GCM3, NTPP_RUEST ;  A4FNQ1, NTPP_SACEN ;  A4X378, NTPP_SALTO ;
DR   Q83JE1, NTPP_SHIFL ;  Q1GP76, NTPP_SPHAL ;  Q82I23, NTPP_STRAW ;
DR   Q9EWV6, NTPP_STRCO ;  Q31RS8, NTPP_SYNE7 ;  Q2JXB4, NTPP_SYNJA ;
DR   Q2JNH4, NTPP_SYNJB ;  Q5N2H7, NTPP_SYNP6 ;  A5GMB7, NTPP_SYNPW ;
DR   Q0IBR4, NTPP_SYNS3 ;  Q3AWW1, NTPP_SYNS9 ;  Q3ALJ5, NTPP_SYNSC ;
DR   P74331, NTPP_SYNY3 ;  Q8DJC5, NTPP_THEVB ;  Q11A17, NTPP_TRIEI ;
DR   Q3MEX6, NTPP_TRIV2 ;  B2I858, NTPP_XYLF2 ;  Q9PEA4, NTPP_XYLFA ;
DR   Q87EA3, NTPP_XYLFT ;  Q5NRI7, NTPP_ZYMMO ;  Q9NV35, NUD15_HUMAN;
DR   Q8BG93, NUD15_MOUSE;  A7ZP69, NUDI_ECO24 ;  B7UFR3, NUDI_ECO27 ;
DR   B7MG18, NUDI_ECO45 ;  B7LAR6, NUDI_ECO55 ;  Q8XE00, NUDI_ECO57 ;
DR   B7NN72, NUDI_ECO7I ;  B7MXT2, NUDI_ECO81 ;  B7M5T3, NUDI_ECO8A ;
DR   C4ZU93, NUDI_ECOBW ;  B1X8W4, NUDI_ECODH ;  A8A2B8, NUDI_ECOHS ;
DR   A1ADA3, NUDI_ECOK1 ;  Q0TFJ1, NUDI_ECOL5 ;  Q8FFM5, NUDI_ECOL6 ;
DR   B1IXT6, NUDI_ECOLC ;  P52006, NUDI_ECOLI ;  B7N5L6, NUDI_ECOLU ;
DR   B6I7J4, NUDI_ECOSE ;  B1LLK5, NUDI_ECOSM ;  Q1R9G4, NUDI_ECOUT ;
DR   A4WDK7, NUDI_ENT38 ;  B7LM80, NUDI_ESCF3 ;  A6TBV3, NUDI_KLEP7 ;
DR   B5XNX5, NUDI_KLEV3 ;  B5EZH4, NUDI_SALA4 ;  A9MJC8, NUDI_SALAR ;
DR   Q57M59, NUDI_SALCH ;  B5FNT5, NUDI_SALDC ;  B5R268, NUDI_SALEP ;
DR   B5RCC0, NUDI_SALG2 ;  B4TBG2, NUDI_SALHS ;  B4SYW7, NUDI_SALNS ;
DR   Q5PC77, NUDI_SALPA ;  A9N5B7, NUDI_SALPB ;  C0Q073, NUDI_SALPC ;
DR   B5BCQ0, NUDI_SALPK ;  B4TPH8, NUDI_SALSV ;  Q8Z544, NUDI_SALTI ;
DR   Q8ZNF5, NUDI_SALTY ;  Q0T2N2, NUDI_SHIF8 ;  Q83KB9, NUDI_SHIFL ;
DR   Q3YZV5, NUDI_SHISS ;
//