ENZYME entry: EC 3.6.4.10

PURL: https://purl.expasy.org/enzyme/EC/3.6.4.10

Accepted Name

non-chaperonin molecular chaperone ATPase

Alternative Name(s)

molecular chaperone Hsc70 ATPase

Reaction catalysed

ATP + H2O = ADP + phosphate + H(+)

Comment(s)

This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
They comprise a number of heat-shock-cognate proteins.
They are also active in clathrin uncoating and in the oligomerization of actin.

Cross-references

BRENDA

3.6.4.10

EC2PDB

3.6.4.10

ExplorEnz

3.6.4.10

KEGG Ligand Database for Enzyme Nomenclature

3.6.4.10

IUBMB Enzyme Nomenclature

3.6.4.10

MEDLINE

Find literature relating to 3.6.4.10

MetaCyc

3.6.4.10

Rhea expert-curated reactions

3.6.4.10

UniProtKB/Swiss-Prot

Q8NB90, AFG2A_HUMAN	Q3UMC0, AFG2A_MOUSE	A7YSY2, AFG2B_BOVIN
Q9BVQ7, AFG2B_HUMAN	A0A7N9VSG0, AFG2B_MOUSE	D4A2B7, AFG2B_RAT
Q0VA52, AFG2B_XENTR	Q21222, AFG2H_CAEEL	O60058, AFG2_SCHPO
P32794, AFG2_YEAST	P20163, BIBH_CAEEL	A0A0D1CD96, BIP1_MYCMD
Q16956, BIP_APLCA	P59769, BIP_ASPAW	P83617, BIP_ASPKA
P83616, BIP_ASPNG	Q0VCX2, BIP_BOVIN	Q6FW50, BIP_CANGA
Q90593, BIP_CHICK	Q9FSY7, BIP_CORAV	G3I8R9, BIP_CRIGR
Q6BZH1, BIP_DEBHA	P29844, BIP_DROME	Q24798, BIP_ECHGR
Q24895, BIP_ECHMU	Q75C78, BIP_EREGS	P16392, BIP_HORSE
P11021, BIP_HUMAN	Q3S4T7, BIP_ICTTR	P22010, BIP_KLULA
P07823, BIP_MESAU	P20029, BIP_MOUSE	P78695, BIP_NEUCR
Q9HG01, BIP_PICAN	P34935, BIP_PIG	A0A509AJG0, BIP_PLABA
P12794, BIP_PLAFA	Q05866, BIP_PLAFO	Q5R4P0, BIP_PONAB
P06761, BIP_RAT	P36604, BIP_SCHPO	Q91883, BIP_XENLA
Q99170, BIP_YARLI	P16474, BIP_YEAST	O76031, CLPX_HUMAN
Q9JHS4, CLPX_MOUSE	Q5R7N3, CLPX_PONAB	Q5U2U0, CLPX_RAT
Q76LV2, HS90A_BOVIN	P46633, HS90A_CRIGR	Q9GKX7, HS90A_HORSE
P07900, HS90A_HUMAN	Q4R4P1, HS90A_MACFA	P07901, HS90A_MOUSE
O02705, HS90A_PIG	P30946, HS90A_RABIT	P82995, HS90A_RAT
P0CS90, HSP77_YEAST	P0CS91, HSP77_YEASX	P19120, HSP7C_BOVIN
P19378, HSP7C_CRIGR	A2Q0Z1, HSP7C_HORSE	P11142, HSP7C_HUMAN
P63017, HSP7C_MOUSE	Q5NVM9, HSP7C_PONAB	P63018, HSP7C_RAT
Q71U34, HSP7C_SAGOE	Q5B0C0, HSP7M_EMENI	P22774, HSP7M_SCHPO
Q05931, HSP7Q_YEAST	Q3ZCH0, HSPA9_BOVIN	P99502, HSPA9_CANLF
Q5ZM98, HSPA9_CHICK	O35501, HSPA9_CRIGR	P38646, HSPA9_HUMAN
P86233, HSPA9_MESAU	P38647, HSPA9_MOUSE	Q5R511, HSPA9_PONAB
P48721, HSPA9_RAT	P87222, SSB1_CANAW	Q876N3, SSB1_CANGA
G0SCU5, SSB1_CHATD	Q75E44, SSB1_EREGS	Q6CQ83, SSB1_KLULA
P41770, SSB1_KLUMA	Q707W3, SSB1_NAKDE	G4NAY4, SSB1_PYRO7
Q10284, SSB1_SCHPO	P11484, SSB1_YEAST	Q707X3, SSB1_ZYGRC
P40150, SSB2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-