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ENZYME entry: EC 3.6.4.10

Accepted Name
non-chaperonin molecular chaperone ATPase.
Alternative Name(s)
molecular chaperone Hsc70 ATPase.
Reaction catalysed
ATP + H2O <=> ADP + H(+) + phosphate
Comment(s)
  • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
  • They comprise a number of heat-shock-cognate proteins.
  • They are also active in clathrin uncoating and in the oligomerization of actin.
Cross-references
BRENDA3.6.4.10
EC2PDB3.6.4.10
ExplorEnz3.6.4.10
PRIAM enzyme-specific profiles3.6.4.10
KEGG Ligand Database for Enzyme Nomenclature3.6.4.10
IUBMB Enzyme Nomenclature3.6.4.10
IntEnz3.6.4.10
MEDLINEFind literature relating to 3.6.4.10
MetaCyc3.6.4.10
Rhea expert-curated reactions3.6.4.10
UniProtKB/Swiss-Prot
Q21222, AFG2H_CAEEL;  O60058, AFG2_SCHPO;  P32794, AFG2_YEAST;  
P20163, BIBH_CAEEL;  A0A0D1CD96, BIP1_USTMA;  Q16956, BIP_APLCA;  
Q75C78, BIP_ASHGO;  P59769, BIP_ASPAW;  P83617, BIP_ASPKA;  
P83616, BIP_ASPNG;  Q0VCX2, BIP_BOVIN;  Q6FW50, BIP_CANGA;  
Q90593, BIP_CHICK;  Q9FSY7, BIP_CORAV;  G3I8R9, BIP_CRIGR;  
Q6BZH1, BIP_DEBHA;  P29844, BIP_DROME;  Q24798, BIP_ECHGR;  
Q24895, BIP_ECHMU;  P16392, BIP_HORSE;  P11021, BIP_HUMAN;  
Q3S4T7, BIP_ICTTR;  P22010, BIP_KLULA;  P07823, BIP_MESAU;  
P20029, BIP_MOUSE;  P78695, BIP_NEUCR;  Q9HG01, BIP_PICAN;  
P34935, BIP_PIG;  P12794, BIP_PLAFA;  Q05866, BIP_PLAFO;  
Q5R4P0, BIP_PONAB;  P06761, BIP_RAT;  P36604, BIP_SCHPO;  
Q91883, BIP_XENLA;  Q99170, BIP_YARLI;  P16474, BIP_YEAST;  
Q76LV2, HS90A_BOVIN;  P46633, HS90A_CRIGR;  Q9GKX7, HS90A_HORSE;  
P07900, HS90A_HUMAN;  Q4R4P1, HS90A_MACFA;  P07901, HS90A_MOUSE;  
O02705, HS90A_PIG;  P30946, HS90A_RABIT;  P82995, HS90A_RAT;  
P0CS90, HSP77_YEAST;  P0CS91, HSP77_YEASX;  P19120, HSP7C_BOVIN;  
P19378, HSP7C_CRIGR;  A2Q0Z1, HSP7C_HORSE;  P11142, HSP7C_HUMAN;  
P63017, HSP7C_MOUSE;  Q5NVM9, HSP7C_PONAB;  P63018, HSP7C_RAT;  
Q5B0C0, HSP7M_EMENI;  P22774, HSP7M_SCHPO;  Q05931, HSP7Q_YEAST;  
A7YSY2, SPA5L_BOVIN;  Q9BVQ7, SPA5L_HUMAN;  A0A7N9VSG0, SPA5L_MOUSE;  
D4A2B7, SPA5L_RAT;  Q0VA52, SPA5L_XENTR;  Q8NB90, SPAT5_HUMAN;  
Q3UMC0, SPAT5_MOUSE;  Q75E44, SSB1_ASHGO;  P87222, SSB1_CANAW;  
Q876N3, SSB1_CANGA;  G0SCU5, SSB1_CHATD;  Q707W3, SSB1_KLUDE;  
Q6CQ83, SSB1_KLULA;  P41770, SSB1_KLUMA;  G4NAY4, SSB1_MAGO7;  
Q10284, SSB1_SCHPO;  P11484, SSB1_YEAST;  Q707X3, SSB1_ZYGRC;  
P40150, SSB2_YEAST;  

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