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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.4.10

Accepted Name
Non-chaperonin molecular chaperone ATPase.
Alternative Name(s)
Molecular chaperone Hsc70 ATPase.
Reaction catalysed
ATP + H(2)O <=> ADP + phosphate
Comment(s)
  • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
  • They comprise a number of heat-shock-cognate proteins.
  • They are also active in clathrin uncoating and in the oligomerization of actin.
Cross-references
PROSITEPDOC00269
BRENDA3.6.4.10
EC2PDB3.6.4.10
ExplorEnz3.6.4.10
PRIAM enzyme-specific profiles3.6.4.10
KEGG Ligand Database for Enzyme Nomenclature3.6.4.10
IUBMB Enzyme Nomenclature3.6.4.10
IntEnz3.6.4.10
MEDLINEFind literature relating to 3.6.4.10
MetaCyc3.6.4.10
UniProtKB/Swiss-Prot
Q21222, AFG2H_CAEEL;  Q8NB90, AFG2H_HUMAN;  Q3UMC0, AFG2H_MOUSE;  
O60058, AFG2_SCHPO;  P32794, AFG2_YEAST;  P20163, BIBH_CAEEL;  
Q16956, BIP_APLCA;  Q75C78, BIP_ASHGO;  P59769, BIP_ASPAW;  
P83617, BIP_ASPKA;  P83616, BIP_ASPNG;  Q0VCX2, BIP_BOVIN;  
Q6FW50, BIP_CANGA;  Q90593, BIP_CHICK;  G3I8R9, BIP_CRIGR;  
Q6BZH1, BIP_DEBHA;  P29844, BIP_DROME;  Q24798, BIP_ECHGR;  
Q24895, BIP_ECHMU;  P16392, BIP_HORSE;  P11021, BIP_HUMAN;  
Q3S4T7, BIP_ICTTR;  P22010, BIP_KLULA;  P07823, BIP_MESAU;  
P20029, BIP_MOUSE;  P78695, BIP_NEUCR;  Q9HG01, BIP_PICAN;  
P34935, BIP_PIG;  P12794, BIP_PLAFA;  Q05866, BIP_PLAFO;  
Q5R4P0, BIP_PONAB;  P06761, BIP_RAT;  P36604, BIP_SCHPO;  
Q91883, BIP_XENLA;  Q99170, BIP_YARLI;  P16474, BIP_YEAST;  
Q75E44, SSB1_ASHGO;  P87222, SSB1_CANAW;  Q876N3, SSB1_CANGA;  
G0SCU5, SSB1_CHATD;  Q707W3, SSB1_KLUDE;  Q6CQ83, SSB1_KLULA;  
P41770, SSB1_KLUMA;  Q10284, SSB1_SCHPO;  P11484, SSB1_YEAST;  
Q707X3, SSB1_ZYGRC;  P40150, SSB2_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-