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ENZYME entry: EC 3.6.4.10

Accepted Name
Non-chaperonin molecular chaperone ATPase.
Alternative Name(s)
Molecular chaperone Hsc70 ATPase.
Reaction catalysed
ATP + H(2)O <=> ADP + phosphate
Comment(s)
  • This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins.
  • They comprise a number of heat-shock-cognate proteins.
  • They are also active in clathrin uncoating and in the oligomerization of actin.
Cross-references
PROSITEPDOC00269
BRENDA3.6.4.10
EC2PDB3.6.4.10
ExplorEnz3.6.4.10
PRIAM enzyme-specific profiles3.6.4.10
KEGG Ligand Database for Enzyme Nomenclature3.6.4.10
IUBMB Enzyme Nomenclature3.6.4.10
IntEnz3.6.4.10
MEDLINEFind literature relating to 3.6.4.10
MetaCyc3.6.4.10
Rhea expert-curated reactions3.6.4.10
UniProtKB/Swiss-Prot
Q21222, AFG2H_CAEEL;  Q8NB90, AFG2H_HUMAN;  Q3UMC0, AFG2H_MOUSE;  
O60058, AFG2_SCHPO;  P32794, AFG2_YEAST;  P20163, BIBH_CAEEL;  
A0A0D1CD96, BIP1_USTMA;  Q16956, BIP_APLCA;  Q75C78, BIP_ASHGO;  
P59769, BIP_ASPAW;  P83617, BIP_ASPKA;  P83616, BIP_ASPNG;  
Q0VCX2, BIP_BOVIN;  Q6FW50, BIP_CANGA;  Q90593, BIP_CHICK;  
Q9FSY7, BIP_CORAV;  G3I8R9, BIP_CRIGR;  Q6BZH1, BIP_DEBHA;  
P29844, BIP_DROME;  Q24798, BIP_ECHGR;  Q24895, BIP_ECHMU;  
P16392, BIP_HORSE;  P11021, BIP_HUMAN;  Q3S4T7, BIP_ICTTR;  
P22010, BIP_KLULA;  P07823, BIP_MESAU;  P20029, BIP_MOUSE;  
P78695, BIP_NEUCR;  Q9HG01, BIP_PICAN;  P34935, BIP_PIG;  
P12794, BIP_PLAFA;  Q05866, BIP_PLAFO;  Q5R4P0, BIP_PONAB;  
P06761, BIP_RAT;  P36604, BIP_SCHPO;  Q91883, BIP_XENLA;  
Q99170, BIP_YARLI;  P16474, BIP_YEAST;  Q76LV2, HS90A_BOVIN;  
P46633, HS90A_CRIGR;  Q9GKX7, HS90A_HORSE;  P07900, HS90A_HUMAN;  
Q4R4P1, HS90A_MACFA;  P07901, HS90A_MOUSE;  O02705, HS90A_PIG;  
P30946, HS90A_RABIT;  P82995, HS90A_RAT;  P0CS90, HSP77_YEAST;  
P0CS91, HSP77_YEASX;  P19120, HSP7C_BOVIN;  P19378, HSP7C_CRIGR;  
A2Q0Z1, HSP7C_HORSE;  P11142, HSP7C_HUMAN;  P63017, HSP7C_MOUSE;  
Q5NVM9, HSP7C_PONAB;  P63018, HSP7C_RAT;  Q5B0C0, HSP7M_EMENI;  
P22774, HSP7M_SCHPO;  Q05931, HSP7Q_YEAST;  Q75E44, SSB1_ASHGO;  
P87222, SSB1_CANAW;  Q876N3, SSB1_CANGA;  G0SCU5, SSB1_CHATD;  
Q707W3, SSB1_KLUDE;  Q6CQ83, SSB1_KLULA;  P41770, SSB1_KLUMA;  
G4NAY4, SSB1_MAGO7;  Q10284, SSB1_SCHPO;  P11484, SSB1_YEAST;  
Q707X3, SSB1_ZYGRC;  P40150, SSB2_YEAST;  

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