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ENZYME

ENZYME entry: EC 3.6.4.12

PURL: https://purl.expasy.org/enzyme/EC/3.6.4.12
Accepted Name
DNA helicase
Reaction catalysed
ATP + H2O = ADP + phosphate + H(+)
Comment(s)
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity, other show 5' to 3' polarity or unwind DNA in both directions.
  • Some helicases unwind DNA as well as RNA.
  • May be identical with EC 3.6.4.13.
Cross-references
BRENDA3.6.4.12
EC2PDB3.6.4.12
ExplorEnz3.6.4.12
KEGG Ligand Database for Enzyme Nomenclature3.6.4.12
IUBMB Enzyme Nomenclature3.6.4.12
MEDLINEFind literature relating to 3.6.4.12
MetaCyc3.6.4.12
Rhea expert-curated reactions3.6.4.12
UniProtKB/Swiss-Prot
Q9Y4B4, ARIP4_HUMANQ99NG0, ARIP4_MOUSEA4IHD2, ARIP4_XENTR
Q9U7E0, ATRX_CAEELQ9GQN5, ATRX_DROMEP46100, ATRX_HUMAN
Q61687, ATRX_MOUSEP82798, ATRX_NOTEUQ7YQM4, ATRX_PANTR
Q7YQM3, ATRX_PONPYP70486, ATRX_RATP83946, ATRY_NOTEU
Q6EVK6, BRM_ARATHP25439, BRM_DROMEO22243, C3H31_ARATH
F4J9M5, CHR12_ARATHQ60EX7, CHR19_ORYSJF4K128, CHR23_ARATH
Q9XFH4, DDM1_ARATHQ05B79, DHX36_BOVINQ9H2U1, DHX36_HUMAN
D4A2Z8, DHX36_RATE1BMP7, DNA2_BOVINQ5ZKG3, DNA2_CHICK
P51530, DNA2_HUMANQ6ZQJ5, DNA2_MOUSED3ZG52, DNA2_RAT
Q9URU2, DNA2_SCHPOQ8QHA5, DNA2_XENLAF6QXW0, DNA2_XENTR
P38859, DNA2_YEASTO75417, DPOLQ_HUMANQ8CGS6, DPOLQ_MOUSE
A6QQR4, ERC6L_BOVINA2BGR3, ERC6L_DANREQ2NKX8, ERC6L_HUMAN
Q8BHK9, ERC6L_MOUSEP87114, FFT1_SCHPOO74842, FFT2_SCHPO
O42861, FFT3_SCHPOP31380, FUN30_YEASTQ32LC7, G3BP1_BOVIN
Q13283, G3BP1_HUMANP97855, G3BP1_MOUSEQ5RB87, G3BP1_PONAB
O94247, HCS1_SCHPOP34243, HCS1_YEASTQ8NG08, HELB_HUMAN
Q6NVF4, HELB_MOUSEO32215, HELD_BACSUP20315, HELIC_BPT3
P03692, HELIC_BPT7P24307, HELI_NPVACF4INY4, HVT1_ARATH
A1CZE5, INO80_NEOFIA4H7G5, JBP2_LEIBRA4HVU6, JBP2_LEIIN
Q4QFY1, JBP2_LEIMAB6EU02, JBP2_LEITAQ57X81, JBP2_TRYB2
Q4DCH3, JBP2_TRYCCA0A1P8ASY1, JHS1_ARATHQ9FQ08, KU70_ARATH
Q2MHH4, KU70_ASPORQ2MHH3, KU70_ASPSOQ2H0I3, KU70_CHAGB
Q1DU75, KU70_COCIMP0CO51, KU70_CRYNBP0CO50, KU70_CRYNJ
Q54MA9, KU70_DICDIQ23976, KU70_DROMEQ5AVC7, KU70_EMENI
Q6CUB4, KU70_KLULAQ7SA95, KU70_NEUCRQ7F1M0, KU70_ORYSJ
Q0U5F2, KU70_PHANOQ26228, KU70_RHIAPO94395, KU70_SCHPO
Q6CCK2, KU70_YARLIP32807, KU70_YEASTQ9FQ09, KU80_ARATH
Q4WI96, KU80_ASPFUQ2MHH2, KU80_ASPORQ2MHH1, KU80_ASPSO
Q2H6C5, KU80_CHAGBQ1E6K9, KU80_COCIMQ5B4H8, KU80_EMENI
Q7RX73, KU80_NEUCRQ75IP6, KU80_ORYSJQ0U8L4, KU80_PHANO
Q9HGM8, KU80_SCHPOQ6C7B9, KU80_YARLIQ04437, KU80_YEAST
Q498J7, MC6ZA_XENLAQ7ZY18, MC6ZB_XENLAQ9LPD9, MCM2_ARATH
P49735, MCM2_DROMEP49736, MCM2_HUMANP97310, MCM2_MOUSE
B8BKI8, MCM2_ORYSIQ2R482, MCM2_ORYSJP40377, MCM2_SCHPO
P55861, MCM2_XENLAQ6DIH3, MCM2_XENTRP29469, MCM2_YEAST
Q43704, MCM31_MAIZEQ9SX04, MCM32_MAIZEQ9SX03, MCM33_MAIZE
P49739, MCM3M_XENLAQ7ZXZ0, MCM3Z_XENLAQ28BS0, MCM3Z_XENTR
Q9FL33, MCM3_ARATHA4FUD9, MCM3_BOVINQ5ZMN2, MCM3_CHICK
Q9XYU1, MCM3_DROMEQ24849, MCM3_ENTH1P25205, MCM3_HUMAN
P25206, MCM3_MOUSEB8AZ99, MCM3_ORYSIQ0DHC4, MCM3_ORYSJ
Q5R8G6, MCM3_PONABP30666, MCM3_SCHPOP24279, MCM3_YEAST
Q5XK83, MCM4A_XENLAP30664, MCM4B_XENLAQ0WVF5, MCM4_ARATH
Q95XQ8, MCM4_CAEELQ26454, MCM4_DROMEP33991, MCM4_HUMAN
P49717, MCM4_MOUSEQ5JKB0, MCM4_ORYSJP29458, MCM4_SCHPO
Q6GL41, MCM4_XENTRP30665, MCM4_YEASTP55862, MCM5A_XENLA
Q6PCI7, MCM5B_XENLAO80786, MCM5_ARATHQ0V8B7, MCM5_BOVIN
Q21902, MCM5_CAEELQ54CP4, MCM5_DICDIQ9VGW6, MCM5_DROME
P33992, MCM5_HUMANP49718, MCM5_MOUSEB8AEH3, MCM5_ORYSI
Q6KAJ4, MCM5_ORYSJP41389, MCM5_SCHPOQ561P5, MCM5_XENTR
P29496, MCM5_YEASTQ5FWY4, MCM6M_XENLAQ28CM3, MCM6M_XENTR
Q6P1V8, MCM6Z_XENTRQ7Q0Q1, MCM6_ANOGAF4KAB8, MCM6_ARATH
Q2KIZ8, MCM6_BOVINQ61J08, MCM6_CAEBRP34647, MCM6_CAEEL
Q86B14, MCM6_DICDIQ9V461, MCM6_DROMEQ29JI9, MCM6_DROPS
Q14566, MCM6_HUMANP97311, MCM6_MOUSEB8AZX3, MCM6_ORYSI
Q6F353, MCM6_ORYSJQ62724, MCM6_RATP49731, MCM6_SCHPO
P53091, MCM6_YEASTQ91876, MCM7A_XENLAQ7ZXB1, MCM7B_XENLA
P43299, MCM7_ARATHQ3ZBH9, MCM7_BOVINQ9XYU0, MCM7_DROME
P33993, MCM7_HUMANQ61881, MCM7_MOUSEB8BMI1, MCM7_ORYSI
Q2QNM1, MCM7_ORYSJO75001, MCM7_SCHPOQ6NX31, MCM7_XENTR
P38132, MCM7_YEASTQ9SF37, MCM8_ARATHE1BPX4, MCM8_BOVIN
I0IUP3, MCM8_CHICKQ9UJA3, MCM8_HUMANQ9CWV1, MCM8_MOUSE
B8AZ14, MCM8_ORYSIB9FKM7, MCM8_ORYSJD3ZVK1, MCM8_RAT
Q5F310, MCM8_XENLAQ0V9Q6, MCM8_XENTRF4IFF3, MCM9_ARATH
F1N2W9, MCM9_BOVINI0IUP4, MCM9_CHICKF1QDI9, MCM9_DANRE
Q9NXL9, MCM9_HUMANQ2KHI9, MCM9_MOUSEB8B406, MCM9_ORYSI
Q69QA6, MCM9_ORYSJF1M5F3, MCM9_RATQ6NRM6, MCM9_XENLA
F6RIX4, MCM9_XENTRQ9UXG1, MCM_SACS2Q9HE09, MFH2_SCHPO
A1CS00, MPH1_ASPCLB0XMV6, MPH1_ASPFCQ4WKB5, MPH1_ASPFU
A2Q8R2, MPH1_ASPNCQ2URJ5, MPH1_ASPORQ0CWI2, MPH1_ASPTN
A6RIS1, MPH1_BOTFBQ5A1A0, MPH1_CANALQ6FPQ3, MPH1_CANGA
Q2HG76, MPH1_CHAGBQ1DY43, MPH1_COCIMQ6BRF0, MPH1_DEBHA
Q75AA7, MPH1_EREGSQ6CQX2, MPH1_KLULAA1D4V5, MPH1_NEOFI
Q7SDF3, MPH1_NEUCRA3GH78, MPH1_PICSTA4RN08, MPH1_PYRO7
Q9UT23, MPH1_SCHPOA7EFH4, MPH1_SCLS1A7TSV4, MPH1_VANPO
A6ZVS0, MPH1_YEAS7P40562, MPH1_YEASTQ8IVL1, NAV2_HUMAN
F4IDQ6, NIH_ARATHQ90185, NS1_AADNVP24030, NS1_ADVG
P27454, NS1_AEDEVP05842, NS1_BMDNVO71153, NS1_DSDNV
P06431, NS1_FPVP24842, NS1_FPV19D0EZM8, NS1_HBOC1
B9UYK5, NS1_HBOC2C5IY48, NS1_HBOC3C5IY43, NS1_HBOC4
Q90054, NS1_JDNVPP27438, NS1_MEVAP07300, NS1_MUMIM
P03134, NS1_MUMIPP07296, NS1_PAVBPP12929, NS1_PAVCN
P03133, NS1_PAVHHP07298, NS1_PAVHUQ9PZT1, NS1_PAVHV
P36311, NS1_PAVL3P52502, NS1_PAVPKP18547, NS1_PAVPN
Q7X9V2, PIE1_ARATHF0NID4, PINA_SACI5Q4J8K8, PINA_SULAC
M5AAG8, POL_BPNNRP10277, PRIM_BPP4F8RL29, R1AB_AMV79
P0C6W1, R1AB_BC133P0C6V9, R1AB_BC279P0C6W0, R1AB_BC512
P0C6W2, R1AB_BCHK3P0C6W3, R1AB_BCHK4P0C6W4, R1AB_BCHK5
P0C6W5, R1AB_BCHK9P0C6W6, R1AB_BCRP3P0C6V7, R1AB_BEV
P0C6V8, R1AB_BRV1P0C6W7, R1AB_CVBENP0C6W8, R1AB_CVBLU
P0C6W9, R1AB_CVBMP0C6X0, R1AB_CVBQP0C6X1, R1AB_CVH22
P0C6X2, R1AB_CVHN1P0C6X3, R1AB_CVHN2P0C6X4, R1AB_CVHN5
P0C6X5, R1AB_CVHNLP0C6X6, R1AB_CVHOCP0C6X8, R1AB_CVM2
P0C6X9, R1AB_CVMA5P0C6Y0, R1AB_CVMJHP0C6Y5, R1AB_CVPPU
Q98VG9, R1AB_FIPVP0C6Y1, R1AB_IBVBP0C6Y2, R1AB_IBVBC
P0C6Y3, R1AB_IBVMK9N7C7, R1AB_MERS1P0C6Y4, R1AB_PEDV7
P0C6X7, R1AB_SARSP0DTD1, R1AB_SARS2Q008X6, R1AB_WBV24
P40352, RAD26_YEASTF1Q8K0, RAD54_DANREQ92698, RAD54_HUMAN
P70270, RAD54_MOUSEP41410, RAD54_SCHPOP32863, RAD54_YEAST
P33919, RADD_ECOLIQ09772, RDH54_SCHPOB3LN76, RDH54_YEAS1
C7GQI8, RDH54_YEAS2B5VE38, RDH54_YEAS6A6ZL17, RDH54_YEAS7
P38086, RDH54_YEASTQ9FJR0, RENT1_ARATHO76512, RENT1_CAEEL
Q54I89, RENT1_DICDIQ9VYS3, RENT1_DROMEQ92900, RENT1_HUMAN
Q9EPU0, RENT1_MOUSEQ9HEH1, RENT1_NEUCRQ09820, RENT1_SCHPO
Q98TR3, RENT1_TAKRUP30771, RENT1_YEASTQ89269, REP40_AAV2S
P03132, REP68_AAV2SQ9FMR9, RIN1_ARATHP19811, RPOA_EAVBU
Q06502, RPOA_LDVCQ83017, RPOA_LDVPQ9YN02, RPOA_PRRS1
Q8B912, RPOA_PRRSBQ04561, RPOA_PRRSLQ9WJB2, RPOA_PRRSR
A0MD28, RPOA_PRRSSA6YQT5, RPOA_PRRSVQ68772, RPOA_SHFV
Q0IFL2, RUVB1_AEDAEQ4WPW8, RUVB1_ASPFUO17607, RUVB1_CAEEL
Q5A0W7, RUVB1_CANALQ6FU78, RUVB1_CANGAP0CR27, RUVB1_CRYNB
P0CR26, RUVB1_CRYNJQ8AWW7, RUVB1_DANREQ6BI60, RUVB1_DEBHA
Q9VH07, RUVB1_DROMEQ29AK9, RUVB1_DROPSQ5BBV9, RUVB1_EMENI
Q8STP2, RUVB1_ENCCUQ750R1, RUVB1_EREGSQ4ICA8, RUVB1_GIBZE
Q9Y265, RUVB1_HUMANQ6CQA9, RUVB1_KLULAP60122, RUVB1_MOUSE
Q4P112, RUVB1_MYCMDQ8WZS3, RUVB1_NEUCRP60123, RUVB1_RAT
Q9C0X6, RUVB1_SCHPOQ9DE26, RUVB1_XENLAQ6CB52, RUVB1_YARLI
Q03940, RUVB1_YEASTQ16TA2, RUVB2_AEDAEQ4WKH9, RUVB2_ASPFU
Q2TBU9, RUVB2_BOVINQ9GZH2, RUVB2_CAEELQ5AGZ9, RUVB2_CANAL
Q6FSF1, RUVB2_CANGAP0CR29, RUVB2_CRYNBP0CR28, RUVB2_CRYNJ
P83571, RUVB2_DANREQ6BSB8, RUVB2_DEBHAQ54UW5, RUVB2_DICDI
Q9V3K3, RUVB2_DROMEQ29DI0, RUVB2_DROPSQ5BGK3, RUVB2_EMENI
Q8SU27, RUVB2_ENCCUQ755G5, RUVB2_EREGSQ4I948, RUVB2_GIBZE
Q9Y230, RUVB2_HUMANQ6CT29, RUVB2_KLULAQ9WTM5, RUVB2_MOUSE
Q4P6N7, RUVB2_MYCMDQ873C7, RUVB2_NEUCRO94692, RUVB2_SCHPO
Q9DE27, RUVB2_XENLAQ6C3X6, RUVB2_YARLIQ12464, RUVB2_YEAST
P38935, SMBP2_HUMANQ60560, SMBP2_MESAUP40694, SMBP2_MOUSE
Q9EQN5, SMBP2_RATE1B7X9, SMRCD_BOVING5EDG2, SMRCD_CAEEL
Q9VL72, SMRCD_DROMEQ9H4L7, SMRCD_HUMANQ04692, SMRCD_MOUSE
D3Z9Z9, SMRCD_RATQ5FWR0, SMRCD_XENTRB0R061, SMRDA_DANRE
E7F1C4, SMRDB_DANREP32597, STH1_YEASTQ4WAS9, SWR1_ASPFU
Q59U81, SWR1_CANALQ6FK48, SWR1_CANGAP0CO19, SWR1_CRYNB
P0CO18, SWR1_CRYNJQ6BKC2, SWR1_DEBHAQ5ARK3, SWR1_EMENI
Q759G7, SWR1_EREGSQ4IAK7, SWR1_GIBZEQ6CJ38, SWR1_KLULA
Q4P328, SWR1_MYCMDQ7S133, SWR1_NEUCRO13682, SWR1_SCHPO
Q6CA87, SWR1_YARLIQ05471, SWR1_YEASTP14565, TRAI1_ECOLI
P22706, TRAI2_ECOLXB5X582, TWIH_ARATHQ83950, V143_NPVOP
F4JFJ3, Y3206_ARATH

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-