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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.4.6

Accepted Name
Vesicle-fusing ATPase.
Reaction catalysed
ATP + H(2)O <=> ADP + phosphate
Comment(s)
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
Cross-references
PROSITEPDOC00572
BRENDA3.6.4.6
EC2PDB3.6.4.6
ExplorEnz3.6.4.6
PRIAM enzyme-specific profiles3.6.4.6
KEGG Ligand Database for Enzyme Nomenclature3.6.4.6
IUBMB Enzyme Nomenclature3.6.4.6
IntEnz3.6.4.6
MEDLINEFind literature relating to 3.6.4.6
MetaCyc3.6.4.6
UniProtKB/Swiss-Prot
Q9P3A7, CDC48_SCHPO;  P25694, CDC48_YEAST;  P46461, NSF1_DROME;  
P54351, NSF2_DROME;  Q9M0Y8, NSF_ARATH;  Q94392, NSF_CAEEL;  
P18708, NSF_CRIGR;  Q75JI3, NSF_DICDI;  P46459, NSF_HUMAN;  
P46460, NSF_MOUSE;  Q5R410, NSF_PONAB;  Q9QUL6, NSF_RAT;  
P54811, TERA1_CAEEL;  P54812, TERA2_CAEEL;  Q3ZBT1, TERA_BOVIN;  
Q7ZU99, TERA_DANRE;  Q7KN62, TERA_DROME;  P55072, TERA_HUMAN;  
Q01853, TERA_MOUSE;  P03974, TERA_PIG;  P46462, TERA_RAT;  
P23787, TERA_XENLA;  Q6GL04, TERA_XENTR;  Q9UN37, VPS4A_HUMAN;  
Q8VEJ9, VPS4A_MOUSE;  Q793F9, VPS4A_RAT;  Q0VD48, VPS4B_BOVIN;  
O75351, VPS4B_HUMAN;  P46467, VPS4B_MOUSE;  Q5R658, VPS4B_PONAB;  
Q9ZNT0, VPS4_ARATH;  Q54PT2, VPS4_DICDI;  Q09803, VPS4_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-