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ENZYME entry: EC 3.6.4.6

Accepted Name
vesicle-fusing ATPase.
Reaction catalysed
ATP + H2O <=> ADP + H(+) + phosphate
Comment(s)
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
Cross-references
BRENDA3.6.4.6
EC2PDB3.6.4.6
ExplorEnz3.6.4.6
PRIAM enzyme-specific profiles3.6.4.6
KEGG Ligand Database for Enzyme Nomenclature3.6.4.6
IUBMB Enzyme Nomenclature3.6.4.6
IntEnz3.6.4.6
MEDLINEFind literature relating to 3.6.4.6
MetaCyc3.6.4.6
Rhea expert-curated reactions3.6.4.6
UniProtKB/Swiss-Prot
Q9P3A7, CDC48_SCHPO;  P25694, CDC48_YEAST;  P46461, NSF1_DROME;  
P54351, NSF2_DROME;  Q9M0Y8, NSF_ARATH;  Q94392, NSF_CAEEL;  
P18708, NSF_CRIGR;  Q75JI3, NSF_DICDI;  P46459, NSF_HUMAN;  
P46460, NSF_MOUSE;  Q0DGP6, NSF_ORYSJ;  Q5R410, NSF_PONAB;  
Q9QUL6, NSF_RAT;  P54811, TERA1_CAEEL;  P54812, TERA2_CAEEL;  
Q3ZBT1, TERA_BOVIN;  Q7ZU99, TERA_DANRE;  Q7KN62, TERA_DROME;  
P55072, TERA_HUMAN;  Q01853, TERA_MOUSE;  P03974, TERA_PIG;  
P46462, TERA_RAT;  P23787, TERA_XENLA;  Q6GL04, TERA_XENTR;  
Q9UN37, VPS4A_HUMAN;  Q8VEJ9, VPS4A_MOUSE;  Q793F9, VPS4A_RAT;  
Q0VD48, VPS4B_BOVIN;  O75351, VPS4B_HUMAN;  P46467, VPS4B_MOUSE;  
Q5R658, VPS4B_PONAB;  Q9ZNT0, VPS4_ARATH;  D0FH76, VPS4_BOMMO;  
Q54PT2, VPS4_DICDI;  Q09803, VPS4_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.4.-
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