ENZYME entry: EC 3.6.5.1
| Accepted Name |
|---|
| heterotrimeric G-protein GTPase.
|
| Reaction catalysed |
|---|
| GTP + H2O <=> GDP + H(+) + phosphate |
| Comment(s) |
|---|
- This group comprises GTP-hydrolyzing systems, where GTP and GDP
alternate in binding.
- This group includes stimulatory and inhibitory G-proteins such as Gs,
Gi, Go and Golf, targeting adenylate cyclase and/or K(+) and Ca(2+)
channels; Gq stimulating phospholipase C; transducin activating cGMP
phosphodiesterase; gustducin activating cAMP phosphodiesterase.
- Golf is instrumental in odor perception, transducin in vision and
gustducin in taste recognition.
- At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36
kDa) and 12 gamma subunits (6-9 kDa) are known.
- Formerly EC 3.6.1.46.
|
| Cross-references |
|---|
| BRENDA | 3.6.5.1 |
| EC2PDB | 3.6.5.1 |
| ExplorEnz | 3.6.5.1 |
| PRIAM enzyme-specific profiles | 3.6.5.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.6.5.1 |
| IUBMB Enzyme Nomenclature | 3.6.5.1 |
| IntEnz | 3.6.5.1 |
| MEDLINE | Find literature relating to 3.6.5.1 |
| MetaCyc | 3.6.5.1 |
| Rhea expert-curated reactions | 3.6.5.1 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-