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ENZYME entry: EC 3.6.5.1

Accepted Name
heterotrimeric G-protein GTPase.
Reaction catalysed
GTP + H2O <=> GDP + H(+) + phosphate
Comment(s)
  • This group comprises GTP-hydrolyzing systems, where GTP and GDP alternate in binding.
  • This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or K(+) and Ca(2+) channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase.
  • Golf is instrumental in odor perception, transducin in vision and gustducin in taste recognition.
  • At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
  • Formerly EC 3.6.1.46.
Cross-references
BRENDA3.6.5.1
EC2PDB3.6.5.1
ExplorEnz3.6.5.1
PRIAM enzyme-specific profiles3.6.5.1
KEGG Ligand Database for Enzyme Nomenclature3.6.5.1
IUBMB Enzyme Nomenclature3.6.5.1
IntEnz3.6.5.1
MEDLINEFind literature relating to 3.6.5.1
MetaCyc3.6.5.1
Rhea expert-curated reactions3.6.5.1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-