ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.5.1

Accepted Name
Heterotrimeric G-protein GTPase.
Reaction catalysed
GTP + H(2)O <=> GDP + phosphate
Comment(s)
This group comprises GTP-hydrolyzing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as G(s), G(i), G(o) and G(olf), targeting adenylate cyclase and/or K(+) and Ca(2+) channels; G(q) stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. G(olf) is instrumental in odor perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known. Formerly EC 3.6.1.46.
Cross-references
PROSITE	PDOC01002
BRENDA	3.6.5.1
EC2PDB	3.6.5.1
ExplorEnz	3.6.5.1
PRIAM enzyme-specific profiles	3.6.5.1
KEGG Ligand Database for Enzyme Nomenclature	3.6.5.1
IUBMB Enzyme Nomenclature	3.6.5.1
IntEnz	3.6.5.1
MEDLINE	Find literature relating to 3.6.5.1
MetaCyc	3.6.5.1

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