- This enzyme comprises a family of proteins involved in prokaryotic as
well as eukaryotic protein synthesis.
- In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP
and subsequently hydrolyzes it in prokaryotes.
- In eukaryotes, it is eIF-2 (150 kDa) that binds GTP.
- In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu
polypeptide of the prokaryotic transfer factor (43 kDa),
the eukaryotic elongation factor EF-1-alpha (53 kDa), the prokaryotic
EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal
recognition particle that play a role in endoplasmic reticulum
protein synthesis (325 kDa).
- EF-Tu and EF-1-alpha catalyze binding of aminoacyl-tRNA to the
ribosomal A-site, while EF-G and EF-2 catalyze the translocation of
peptidyl-tRNA from the A-site to the P-site.
- GTPase activity is also involved in polypeptide release from the
ribosome with the aid of the pRFs and eRFs.
- Formerly EC 3.6.1.48.
|
| UniProtKB/Swiss-Prot |
| Q2VIR3, IF2GL_HUMAN; | Q9Y9C1, IF2G_AERPE; | O29663, IF2G_ARCFU; |
| Q2KHU8, IF2G_BOVIN; | Q5ZMS3, IF2G_CHICK; | J9VR81, IF2G_CRYNH; |
| F1QGW6, IF2G_DANRE; | Q54XD8, IF2G_DICDI; | Q24208, IF2G_DROME; |
| O96719, IF2G_ENCCU; | B9LSM6, IF2G_HALLT; | Q5UYS2, IF2G_HALMA; |
| B0R6Y7, IF2G_HALS3; | Q9HNK9, IF2G_HALSA; | Q18KI6, IF2G_HALWD; |
| P41091, IF2G_HUMAN; | A6UTL4, IF2G_META3; | Q8TJT7, IF2G_METAC; |
| Q58657, IF2G_METJA; | Q8TVE5, IF2G_METKA; | A4FWW9, IF2G_METM5; |
| A9AAA4, IF2G_METM6; | A6VGE8, IF2G_METM7; | Q8PZA0, IF2G_METMA; |
| Q6LXY6, IF2G_METMP; | O26361, IF2G_METTH; | A6UPK8, IF2G_METVS; |
| Q9Z0N1, IF2G_MOUSE; | Q3IMM5, IF2G_NATPD; | Q5R797, IF2G_PONAB; |
| Q9V1G0, IF2G_PYRAB; | Q8U082, IF2G_PYRFU; | O59410, IF2G_PYRHO; |
| P81795, IF2G_RAT; | Q980A5, IF2G_SACS2; | Q09130, IF2G_SCHPO; |
| O36041, IF2G_SPIVO; | Q975N8, IF2G_SULTO; | Q9HLA7, IF2G_THEAC; |
| Q5JDL3, IF2G_THEKO; | B6YW69, IF2G_THEON; | Q978W8, IF2G_THEVO; |
| P32481, IF2G_YEAST; | Q9Z0N2, IF2H_MOUSE; | C9WPN6, IF2H_RAT; |
| G0S8G9, IF2P_CHATD; | Q54XP6, IF2P_DICDI; | O60841, IF2P_HUMAN; |
| Q05D44, IF2P_MOUSE; | Q5RDE1, IF2P_PONAB; | B2GUV7, IF2P_RAT; |
| Q10251, IF2P_SCHPO; | P39730, IF2P_YEAST; |
|