- This enzyme comprises a family of proteins involved in prokaryotic as
well as eukaryotic protein synthesis.
- In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP
and subsequently hydrolyzes it in prokaryotes.
- In eukaryotes, it is eIF-2 (150 kDa) that binds GTP.
- In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu
polypeptide of the prokaryotic transfer factor (43 kDa),
the eukaryotic elongation factor EF-1-alpha (53 kDa), the prokaryotic
EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal
recognition particle that play a role in endoplasmic reticulum
protein synthesis (325 kDa).
- EF-Tu and EF-1-alpha catalyze binding of aminoacyl-tRNA to the
ribosomal A-site, while EF-G and EF-2 catalyze the translocation of
peptidyl-tRNA from the A-site to the P-site.
- GTPase activity is also involved in polypeptide release from the
ribosome with the aid of the pRFs and eRFs.
- Formerly EC 22.214.171.124.
|Q2VIR3, IF2GL_HUMAN; ||Q9Y9C1, IF2G_AERPE; ||O29663, IF2G_ARCFU; |
|Q2KHU8, IF2G_BOVIN; ||Q5ZMS3, IF2G_CHICK; ||J9VR81, IF2G_CRYNH; |
|F1QGW6, IF2G_DANRE; ||Q54XD8, IF2G_DICDI; ||Q24208, IF2G_DROME; |
|O96719, IF2G_ENCCU; ||B9LSM6, IF2G_HALLT; ||Q5UYS2, IF2G_HALMA; |
|B0R6Y7, IF2G_HALS3; ||Q9HNK9, IF2G_HALSA; ||Q18KI6, IF2G_HALWD; |
|P41091, IF2G_HUMAN; ||A6UTL4, IF2G_META3; ||Q8TJT7, IF2G_METAC; |
|Q58657, IF2G_METJA; ||Q8TVE5, IF2G_METKA; ||A4FWW9, IF2G_METM5; |
|A9AAA4, IF2G_METM6; ||A6VGE8, IF2G_METM7; ||Q8PZA0, IF2G_METMA; |
|Q6LXY6, IF2G_METMP; ||O26361, IF2G_METTH; ||A6UPK8, IF2G_METVS; |
|Q9Z0N1, IF2G_MOUSE; ||Q3IMM5, IF2G_NATPD; ||Q5R797, IF2G_PONAB; |
|Q9V1G0, IF2G_PYRAB; ||Q8U082, IF2G_PYRFU; ||O59410, IF2G_PYRHO; |
|P81795, IF2G_RAT; ||Q980A5, IF2G_SACS2; ||Q09130, IF2G_SCHPO; |
|O36041, IF2G_SPIVO; ||Q975N8, IF2G_SULTO; ||Q9HLA7, IF2G_THEAC; |
|Q5JDL3, IF2G_THEKO; ||B6YW69, IF2G_THEON; ||Q978W8, IF2G_THEVO; |
|P32481, IF2G_YEAST; ||Q9Z0N2, IF2H_MOUSE; ||C9WPN6, IF2H_RAT; |
|G0S8G9, IF2P_CHATD; ||Q54XP6, IF2P_DICDI; ||O60841, IF2P_HUMAN; |
|Q05D44, IF2P_MOUSE; ||Q5RDE1, IF2P_PONAB; ||B2GUV7, IF2P_RAT; |
|Q10251, IF2P_SCHPO; ||P39730, IF2P_YEAST; |