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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Cobalt-precorrin 5A hydrolase.
Reaction catalysed
Cobalt-precorrin-5A + H(2)O <=> cobalt-precorrin-5B + acetaldehyde + 2 H(+)
  • This enzyme hydrolyzes the ring A acetate delta-lactone of cobalt- precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.
  • This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.
PRIAM enzyme-specific profiles3.7.1.12
KEGG Ligand Database for Enzyme Nomenclature3.7.1.12
IUBMB Enzyme Nomenclature3.7.1.12
MEDLINEFind literature relating to
O87697, CBIG_BACME;  Q58544, CBIG_METJA;  Q05631, CBIG_SALTY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.7.1.-
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