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ENZYME entry: EC 3.7.1.28

Accepted Name
3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase.
Reaction catalysed
3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)
Comment(s)
  • The enzyme, which belongs to the RuBisCO-like-protein (RLP) superfamily, has been characterized from several bacterial species.
  • It participates in the degradation of D-apionate.
  • The reaction is initiated by decarboxylation to generate a stabilized enediolate intermediate, with the sequestered CO2 carboxylating the adjacent enediolate carbon atom.
  • The resulting 3-ketose-1-phosphate intermediate is hydrolyzed, as in the authentic RuBisCO-catalyzed reaction, to generate glycolate and 3-phospho-D-glycerate.
  • Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined.
Cross-references
BRENDA3.7.1.28
EC2PDB3.7.1.28
ExplorEnz3.7.1.28
PRIAM enzyme-specific profiles3.7.1.28
KEGG Ligand Database for Enzyme Nomenclature3.7.1.28
IUBMB Enzyme Nomenclature3.7.1.28
IntEnz3.7.1.28
MEDLINEFind literature relating to 3.7.1.28
MetaCyc3.7.1.28
Rhea expert-curated reactions3.7.1.28

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-