ID   4.1.1.90
DE   peptidyl-glutamate 4-carboxylase.
AN   gamma-glutamyl carboxylase.
AN   vitamin K-dependent carboxylase.
CA   2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O =
CA   CO2 + L-glutamyl-[protein] + O2 + phylloquinol.
CC   -!- The enzyme can use various vitamin-K derivatives, including
CC       menaquinol, but does not contain iron.
CC   -!- The mechanism appears to involve the generation of a strong base by
CC       oxygenation of vitamin K.
CC   -!- It catalyzes the post-translational carboxylation of glutamate
CC       residues of several proteins of the blood-clotting system.
CC   -!- 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in
CC       a specific domain of the target protein.
CC   -!- The 4-pro-S hydrogen of the glutamate residue is removed and there is
CC       an inversion of stereochemistry at this position.
DR   Q07175, VKGC_BOVIN ;  Q9MYY3, VKGC_DELLE ;  P38435, VKGC_HUMAN ;
DR   Q9QYC7, VKGC_MOUSE ;  Q5RF50, VKGC_PONAB ;  O88496, VKGC_RAT   ;
DR   Q9GL59, VKGC_SHEEP ;
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