ID 4.1.99.22 DE GTP 3',8-cyclase. CA AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8- CA dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + CA L-methionine. CC -!- The enzyme catalyzes an early step in the biosynthesis of the CC molybdenum cofactor (MoCo). CC -!- The enzyme belongs to the superfamily of radical S-adenosyl-L- CC methionine (radical SAM) enzymes. CC -!- Formerly EC 4.1.99.18. DR Q39055, CNX2_ARATH ; Q7TX84, MOAA1_MYCBO; P9WJS2, MOAA1_MYCTO; DR P9WJS3, MOAA1_MYCTU; Q9HXD6, MOAA1_PSEAE; P65385, MOAA2_MYCBO; DR P9WJS0, MOAA2_MYCTO; P9WJS1, MOAA2_MYCTU; Q9I3K7, MOAA2_PSEAE; DR P62588, MOAA3_MYCBO; P62589, MOAA3_MYCTO; B0CDZ6, MOAA_ACAM1 ; DR A0LVG0, MOAA_ACIC1 ; A3N054, MOAA_ACTP2 ; B3GXC5, MOAA_ACTP7 ; DR B0BNX2, MOAA_ACTPJ ; A6VPY2, MOAA_ACTSZ ; A0KIL8, MOAA_AERHH ; DR Q9YEV3, MOAA_AERPE ; Q8UER0, MOAA_AGRFC ; A8ERS0, MOAA_ALIB4 ; DR A6TVF9, MOAA_ALKMQ ; A8MLW5, MOAA_ALKOO ; O67929, MOAA_AQUAE ; DR O28273, MOAA_ARCFU ; C3LA56, MOAA_BACAC ; A7GU01, MOAA_BACCN ; DR Q65DY5, MOAA_BACLD ; P39757, MOAA_BACSU ; A7Z9P0, MOAA_BACVZ ; DR Q89NT2, MOAA_BRADU ; C0Z9B3, MOAA_BREBN ; B2S5I1, MOAA_BRUA1 ; DR Q2YNT7, MOAA_BRUA2 ; Q57DG3, MOAA_BRUAB ; A9MAX5, MOAA_BRUC2 ; DR C0RIT4, MOAA_BRUMB ; Q8YGY6, MOAA_BRUME ; A5VQC9, MOAA_BRUO2 ; DR B0CLT0, MOAA_BRUSI ; Q8G0X4, MOAA_BRUSU ; A7ZB87, MOAA_CAMC1 ; DR A7GWA5, MOAA_CAMC5 ; A0RMJ2, MOAA_CAMFF ; A8FJX0, MOAA_CAMJ8 ; DR A7H1N9, MOAA_CAMJD ; Q9PIW6, MOAA_CAMJE ; A1VXP5, MOAA_CAMJJ ; DR Q5HX04, MOAA_CAMJR ; B9KDV3, MOAA_CAMLR ; Q3ADX8, MOAA_CARHZ ; DR Q9AC48, MOAA_CAUVC ; P59038, MOAA_CHLTE ; Q97HL8, MOAA_CLOAB ; DR A7FUZ6, MOAA_CLOB1 ; C3KXJ8, MOAA_CLOB6 ; A5I365, MOAA_CLOBH ; DR C1FPG7, MOAA_CLOBJ ; B1IN35, MOAA_CLOBK ; A7GEQ5, MOAA_CLOBL ; DR B1KU20, MOAA_CLOBM ; Q0TPG6, MOAA_CLOP1 ; Q9WX96, MOAA_CLOPE ; DR Q0SS32, MOAA_CLOPS ; A4QDF8, MOAA_CORGB ; Q8NR60, MOAA_CORGL ; DR B1X0G3, MOAA_CROS5 ; A7MJ10, MOAA_CROS8 ; B8HWW4, MOAA_CYAP4 ; DR A4J6S5, MOAA_DESRM ; A8LIR8, MOAA_DINSH ; A7ZJJ0, MOAA_ECO24 ; DR B7ULX8, MOAA_ECO27 ; B7MGN9, MOAA_ECO45 ; B7LC63, MOAA_ECO55 ; DR P65383, MOAA_ECO57 ; B5YRM0, MOAA_ECO5E ; B7NNL1, MOAA_ECO7I ; DR B7MQN5, MOAA_ECO81 ; B7M753, MOAA_ECO8A ; C4ZXV3, MOAA_ECOBW ; DR B1X7B1, MOAA_ECODH ; A7ZY37, MOAA_ECOHS ; P65382, MOAA_ECOL6 ; DR P30745, MOAA_ECOLI ; B7NA81, MOAA_ECOLU ; B6I7T6, MOAA_ECOSE ; DR B1LM72, MOAA_ECOSM ; C5B7H2, MOAA_EDWI9 ; Q2NCE3, MOAA_ERYLH ; DR B7LJY1, MOAA_ESCF3 ; Q747W9, MOAA_GEOSL ; Q7NCF5, MOAA_GLOVI ; DR Q7VLN1, MOAA_HAEDU ; Q4QJR9, MOAA_HAEI8 ; A5UBK4, MOAA_HAEIE ; DR A5UFB4, MOAA_HAEIG ; P45311, MOAA_HAEIN ; Q9K9W9, MOAA_HALH5 ; DR B0R2L5, MOAA_HALS3 ; Q9HST4, MOAA_HALSA ; Q18G49, MOAA_HALWD ; DR B0TI16, MOAA_HELMI ; B6JM01, MOAA_HELP2 ; Q1CTA2, MOAA_HELPH ; DR Q9ZL75, MOAA_HELPJ ; P56414, MOAA_HELPY ; Q31JB9, MOAA_HYDCU ; DR B5XYW6, MOAA_KLEP3 ; A6T6M5, MOAA_KLEP7 ; Q88WY1, MOAA_LACPL ; DR B2GCN4, MOAA_LIMF3 ; Q92CY2, MOAA_LISIN ; C1L1W8, MOAA_LISMC ; DR Q721B9, MOAA_LISMF ; Q8Y870, MOAA_LISMO ; A0AHG0, MOAA_LISW6 ; DR A0L7R4, MOAA_MAGMM ; Q65TT2, MOAA_MANSM ; A1U578, MOAA_MARN8 ; DR C6C060, MOAA_MARSD ; A6UX30, MOAA_META3 ; Q8TUG2, MOAA_METAC ; DR Q0W3L5, MOAA_METAR ; Q58234, MOAA_METJA ; Q8TV60, MOAA_METKA ; DR A4FYQ8, MOAA_METM5 ; A9A661, MOAA_METM6 ; A6VJM2, MOAA_METM7 ; DR Q8PX29, MOAA_METMA ; Q6LZQ3, MOAA_METMP ; A4YH62, MOAA_METS5 ; DR O27593, MOAA_METTH ; Q50746, MOAA_METTM ; A6US67, MOAA_METVS ; DR B0JNC2, MOAA_MICAN ; Q2RGL2, MOAA_MOOTA ; B2HFA4, MOAA_MYCMM ; DR A0R443, MOAA_MYCS2 ; A3Q648, MOAA_MYCSJ ; A1ULP7, MOAA_MYCSK ; DR Q1B3F3, MOAA_MYCSS ; A0PKZ7, MOAA_MYCUA ; B9L851, MOAA_NAUPA ; DR Q1QN98, MOAA_NITHX ; A6Q5D0, MOAA_NITSB ; Q3STB0, MOAA_NITWN ; DR B2J1M7, MOAA_NOSP7 ; Q8YQG6, MOAA_NOSS1 ; Q44118, MOAA_PAENI ; DR A1B4A2, MOAA_PARDP ; Q7U3H2, MOAA_PARMW ; Q9CN21, MOAA_PASMU ; DR Q6D3C7, MOAA_PECAS ; A5CYZ0, MOAA_PELTS ; Q93KD1, MOAA_PEPAC ; DR A9BF51, MOAA_PETMO ; Q7N6P6, MOAA_PHOLL ; B1XLR4, MOAA_PICP2 ; DR Q48HV8, MOAA_PSE14 ; Q1I6J5, MOAA_PSEE4 ; A4XW05, MOAA_PSEMY ; DR A5VZZ2, MOAA_PSEP1 ; Q3KAS8, MOAA_PSEPF ; B0KST1, MOAA_PSEPG ; DR Q88E69, MOAA_PSEPK ; B1JCW0, MOAA_PSEPW ; Q882V6, MOAA_PSESM ; DR Q4ZU05, MOAA_PSEU2 ; A1SWQ3, MOAA_PSYIN ; Q9V2G2, MOAA_PYRAB ; DR Q8ZYE5, MOAA_PYRAE ; Q8U4J5, MOAA_PYRFU ; O57854, MOAA_PYRHO ; DR Q8Y0K4, MOAA_RALN1 ; B3PQ08, MOAA_RHIE6 ; Q2K7L4, MOAA_RHIEC ; DR Q98MK6, MOAA_RHILO ; B5ZRM8, MOAA_RHILW ; Q92PB4, MOAA_RHIME ; DR Q7UT69, MOAA_RHOBA ; Q9X5W3, MOAA_RHOCA ; Q0S2N2, MOAA_RHOJR ; DR C1B1N5, MOAA_RHOOB ; Q3V7S1, MOAA_RHOPA ; Q139F2, MOAA_RHOPS ; DR B3QCQ7, MOAA_RHOPT ; B7JWW6, MOAA_RIPO1 ; Q21I62, MOAA_SACD2 ; DR Q980F0, MOAA_SACS2 ; B5F079, MOAA_SALA4 ; B5FP68, MOAA_SALDC ; DR B5QX73, MOAA_SALEP ; B5R769, MOAA_SALG2 ; B4TC55, MOAA_SALHS ; DR B4SZK4, MOAA_SALNS ; Q5PG37, MOAA_SALPA ; A9MTH7, MOAA_SALPB ; DR C0PWZ0, MOAA_SALPC ; B5BC24, MOAA_SALPK ; B4TQU6, MOAA_SALSV ; DR P65387, MOAA_SALTI ; P65386, MOAA_SALTY ; Q12T28, MOAA_SHEDO ; DR B2TVE9, MOAA_SHIB3 ; Q324B1, MOAA_SHIBS ; Q32I50, MOAA_SHIDS ; DR Q83S40, MOAA_SHIFL ; Q3Z403, MOAA_SHISS ; A6U9U3, MOAA_SINMW ; DR A7X5J1, MOAA_STAA1 ; A6U3Z2, MOAA_STAA2 ; Q2FEM4, MOAA_STAA3 ; DR P69848, MOAA_STAA8 ; A5IV50, MOAA_STAA9 ; Q2YYS8, MOAA_STAAB ; DR Q5HDT9, MOAA_STAAC ; A6QJA8, MOAA_STAAE ; Q931G4, MOAA_STAAM ; DR P65388, MOAA_STAAN ; Q6GEG6, MOAA_STAAR ; Q6G754, MOAA_STAAS ; DR A8Z366, MOAA_STAAT ; P65389, MOAA_STAAW ; Q9ZIM6, MOAA_STACT ; DR Q5HLY1, MOAA_STAEQ ; Q8CNE6, MOAA_STAES ; Q4L8D2, MOAA_STAHJ ; DR Q49ZI6, MOAA_STAS1 ; Q9RJ47, MOAA_STRCO ; B4SL67, MOAA_STRM5 ; DR B2FUM0, MOAA_STRMK ; Q4J8T0, MOAA_SULAC ; Q30P92, MOAA_SULDN ; DR C3MZ99, MOAA_SULIA ; C4KIH7, MOAA_SULIK ; C3MR64, MOAA_SULIL ; DR C3MXF3, MOAA_SULIM ; C3NGB5, MOAA_SULIN ; C3N7B9, MOAA_SULIY ; DR A6Q6R2, MOAA_SULNB ; Q971H1, MOAA_SULTO ; Q56211, MOAA_SYNE7 ; DR Q2JI46, MOAA_SYNJB ; Q5N5F7, MOAA_SYNP6 ; Q9EYN8, MOAA_SYNPW ; DR Q3AVP9, MOAA_SYNS9 ; Q3AGB7, MOAA_SYNSC ; Q0AVU6, MOAA_SYNWW ; DR Q55369, MOAA_SYNY3 ; Q9HKZ7, MOAA_THEAC ; Q5JHN5, MOAA_THEKO ; DR Q979T0, MOAA_THEVO ; B5YJ09, MOAA_THEYD ; C4LFK3, MOAA_TOLAT ; DR Q119N9, MOAA_TRIEI ; Q3MC34, MOAA_TRIV2 ; B7VLU4, MOAA_VIBA3 ; DR A5F2Q5, MOAA_VIBC3 ; Q9KT81, MOAA_VIBCH ; C3LTS1, MOAA_VIBCM ; DR Q87MY0, MOAA_VIBPA ; Q8D894, MOAA_VIBVU ; Q7MM75, MOAA_VIBVY ; DR Q8PNH1, MOAA_XANAC ; Q4URN0, MOAA_XANC8 ; B0RTE0, MOAA_XANCB ; DR Q8PBX1, MOAA_XANCP ; Q8ZGW5, MOAA_YERPE ; Q1JQD7, MOCS1_BOVIN; DR Q20624, MOCS1_CAEEL; Q54NM6, MOCS1_DICDI; Q8IQF1, MOCS1_DROME; DR Q9NZB8, MOCS1_HUMAN; Q5RKZ7, MOCS1_MOUSE; //