ID   4.1.99.24
DE   L-tyrosine isonitrile synthase.
CA   D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-
CA   isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone +
CA   phosphate.
CC   -!- The enzymes from the bacteria Pseudomonas aeruginosa and Xenorhabdus
CC       nematophila are involved in the biosynthesis of paerucumarin and
CC       rhabduscin, respectively.
CC   -!- According to the proposed mechanism, the enzyme forms an imine
CC       intermediate composed of linked L-tyrosine and D-ribulose
CC       5-phosphate, followed by loss of the phosphate group and formation of
CC       a beta-keto imine and keto-enol tautomerization.
CC   -!- This is followed by a C-C bond cleavage, the release of acetol, and a
CC       retro aldol type reaction that releases formaldehyde and forms the
CC       final product. cf. EC 4.1.99.25.
DR   Q9I1L5, PVCA_PSEAE ;  D3V9Q4, PVCA_XENNA ;
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