ID   4.2.1.114
DE   methanogen homoaconitase.
AN   methanogen HACN.
CA   (2R)-homocitrate = (2R,3S)-homoisocitrate.
CC   -!- Catalyzes several reactions in the pathway of coenzyme-B biosynthesis
CC       in methanogenic archaea.
CC   -!- In contrast to EC 4.2.1.36, this enzyme can catalyze both the
CC       dehydration of (R)-homocitrate to form cis-homoaconitate and the
CC       subsequent hydration reaction that forms homoisocitrate.
CC   -!- In addition to cis-homoaconitate, the enzyme can also catalyze the
CC       hydration of the physiological substrates dihomoaconitate and
CC       trihomoaconitate as well as the non-physiological substrate
CC       tetrahomoaconitate.
CC   -!- cis-Aconitate and threo-DL-isocitrate cannot act as substrates,
CC       and (S)-homocitrate and trans-homoaconitate act as inhibitors of the
CC       enzyme.
DR   Q8TLF1, HACA_METAC ;  Q58409, HACA_METJA ;  Q8PZT3, HACA_METMA ;
DR   O27668, HACA_METTH ;  Q8TJM9, HACB1_METAC;  Q8TRF7, HACB2_METAC;
DR   Q58667, HACB_METJA ;  Q8PZ49, HACB_METMA ;  O26917, HACB_METTH ;
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