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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.2.1.135

Accepted Name
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining).
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine <=> UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H(2)O
Cofactor(s)
NAD(+).
Comment(s)
  • This is the first enzyme in the biosynthetic pathway of N,N'-diacetylbacillosamine, the first carbohydrate in the glycoprotein N-linked heptasaccharide in Campylobacter jejuni.
  • This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes.
Cross-references
BRENDA4.2.1.135
EC2PDB4.2.1.135
ExplorEnz4.2.1.135
PRIAM enzyme-specific profiles4.2.1.135
KEGG Ligand Database for Enzyme Nomenclature4.2.1.135
IUBMB Enzyme Nomenclature4.2.1.135
IntEnz4.2.1.135
MEDLINEFind literature relating to 4.2.1.135
MetaCyc4.2.1.135
UniProtKB/Swiss-Prot
Q0P9D4, PGLF_CAMJE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-