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ENZYME entry: EC 4.2.1.139

Accepted Name
Pterocarpan synthase.
Alternative Name(s)
2',7-dihydroxy-4'-methoxyisoflavanol dehydratase.
2'-hydroxyisoflavanol 4,2'-dehydratase.
7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase.
Medicarpan synthase.
Medicarpin synthase.
Reaction catalysed
A (4R)-4,2'-dihydroxyisoflavan <=> a pterocarpan + H(2)O
Comment(s)
  • The enzyme catalyzes the formation of the additional ring in pterocarpan, the basic structure of phytoalexins produced by leguminous plants, including (-)-medicarpin, (+)-medicarpin, (-)- maackiain and (+)-maackiain.
  • The enzyme requires that the hydroxyl group at C-4 of the substrate is in the (4R) configuration.
  • The configuration of the hydrogen atom at C-3 determines whether the pterocarpan is the (+)- or (-)-enantiomer.
  • The enzyme contains amino acid motifs characteristic of dirigent proteins.
  • Formerly EC 1.1.1.246.
Cross-references
BRENDA4.2.1.139
EC2PDB4.2.1.139
ExplorEnz4.2.1.139
PRIAM enzyme-specific profiles4.2.1.139
KEGG Ligand Database for Enzyme Nomenclature4.2.1.139
IUBMB Enzyme Nomenclature4.2.1.139
IntEnz4.2.1.139
MEDLINEFind literature relating to 4.2.1.139
MetaCyc4.2.1.139
UniProtKB/Swiss-Prot
A0A1V1FH01, DIR_GLYEC;  I1JNN8, DIR_SOYBN;  

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