ID   4.2.1.152
DE   hydroperoxy icosatetraenoate dehydratase.
AN   epidermal lipoxygenase-3.
CA   a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O.
CC   -!- The mammalian enzymes accept a range of hydroperoxy icosatetraenoates
CC       (HPETE).
CC   -!- The human enzyme has highest activity with (12R)-HPETE, followed by
CC       (12S)-HPETE and (15R)-HPETE with much lower efficiency.
CC   -!- The murine enzyme has highest activity with (8R)-HPETE followed by
CC       (8S)-HPETE. All HPETE isoforms are converted to the corresponding
CC       oxoicosatetraenoate forms (KETE).
CC   -!- The enzymes also catalyze the reaction of EC 5.4.4.7.
DR   Q3LFU0, CP1A1_BALAC;  P56590, CP1A1_CANLF;  Q06367, CP1A1_CAVPO;
DR   Q5KQT7, CP1A1_FELCA;  P04798, CP1A1_HUMAN;  P33616, CP1A1_MACFA;
DR   Q6GUR1, CP1A1_MACMU;  Q00557, CP1A1_MESAU;  P00184, CP1A1_MOUSE;
DR   P05176, CP1A1_RABIT;  P00185, CP1A1_RAT  ;  P56591, CP1A1_SHEEP;
DR   Q3LFT9, CP1A2_BALAC;  O77810, CP1A2_CALJA;  P56592, CP1A2_CANLF;
DR   Q64391, CP1A2_CAVPO;  Q5KQT6, CP1A2_FELCA;  P05177, CP1A2_HUMAN;
DR   O77809, CP1A2_MACFA;  Q4H4C3, CP1A2_MACFU;  P24453, CP1A2_MESAU;
DR   P00186, CP1A2_MOUSE;  Q5RBQ1, CP1A2_PONAB;  P00187, CP1A2_RABIT;
DR   P04799, CP1A2_RAT  ;  Q16678, CP1B1_HUMAN;  Q64429, CP1B1_MOUSE;
DR   Q64678, CP1B1_RAT  ;  Q96SQ9, CP2S1_HUMAN;  Q9DBX6, CP2S1_MOUSE;
DR   Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;  D3ZKX9, LOXE3_RAT  ;
DR   Q29626, PTGIS_BOVIN;  F1RE08, PTGIS_DANRE;  Q16647, PTGIS_HUMAN;
DR   O35074, PTGIS_MOUSE;  Q62969, PTGIS_RAT  ;  Q2KIG5, THAS_BOVIN ;
DR   P24557, THAS_HUMAN ;  Q2PG45, THAS_MACFA ;  P36423, THAS_MOUSE ;
DR   P47787, THAS_PIG   ;  P49430, THAS_RAT   ;
//