ID   4.2.1.93
DE   ATP-dependent NAD(P)H-hydrate dehydratase.
AN   ATP-dependent H4NAD(P)OH dehydratase.
CA   (1) (6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate.
CA   (2) (6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate.
CC   -!- Acts equally well on hydrated NADH and hydrated NADPH.
CC   -!- NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers,
CC       and these are interconverted by EC 5.1.99.6, to a 60:40 ratio.
CC   -!- Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture
CC       of hydrates into NAD(P)H.
CC   -!- The enzyme from eukaryotes has no activity with ADP, contrary to the
CC       enzyme from bacteria (cf. EC 4.2.1.136).
DR   E3LAQ9, NNRD1_PUCGT;  E3L9T1, NNRD2_PUCGT;  Q17NP0, NNRD_AEDAE ;
DR   C0NFV9, NNRD_AJECG ;  E3XDZ8, NNRD_ANODA ;  Q94AF2, NNRD_ARATH ;
DR   Q4X1F8, NNRD_ASPFU ;  F4NZ38, NNRD_BATDJ ;  E1BNQ4, NNRD_BOVIN ;
DR   A8X354, NNRD_CAEBR ;  P32740, NNRD_CAEEL ;  Q59M69, NNRD_CANAL ;
DR   C4YSU5, NNRD_CANAW ;  E2QUI9, NNRD_CANLF ;  F6RCC2, NNRD_CIOIN ;
DR   A8N8Z0, NNRD_COPC7 ;  Q5K8L4, NNRD_CRYNJ ;  F1Q575, NNRD_DANRE ;
DR   Q54FJ9, NNRD_DICDI ;  Q9VVW8, NNRD_DROME ;  B5DHB2, NNRD_DROPS ;
DR   Q5B0D6, NNRD_EMENI ;  C4LZV8, NNRD_ENTH1 ;  C7YKN8, NNRD_FUSV7 ;
DR   D3BMU4, NNRD_HETP5 ;  Q8IW45, NNRD_HUMAN ;  B7PBI5, NNRD_IXOSC ;
DR   F7E727, NNRD_MACMU ;  Q9CZ42, NNRD_MOUSE ;  A7RRZ8, NNRD_NEMVE ;
DR   Q7SHU9, NNRD_NEUCR ;  E0VSF4, NNRD_PEDHC ;  Q0UVK8, NNRD_PHANO ;
DR   B7FXE8, NNRD_PHATC ;  A9RY03, NNRD_PHYPA ;  Q5R824, NNRD_PONAB ;
DR   D4AAT7, NNRD_RAT   ;  O94347, NNRD_SCHPO ;  C5Y210, NNRD_SORBI ;
DR   Q4P219, NNRD_USTMA ;  F6HDM2, NNRD_VITVI ;  P36059, NNRD_YEAST ;
//