ID   4.2.1.96
DE   4a-hydroxytetrahydrobiopterin dehydratase.
AN   4alpha-hydroxy-tetrahydropterin dehydratase.
AN   pterin-4alpha-carbinolamine dehydratase.
AN   tetrahydrobiopterin dehydratase.
CA   (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-
CA   erythro-6,7-dihydrobiopterin + H2O.
CC   -!- In concert with EC 1.5.1.34 the enzyme recycles
CC       4a-hydroxytetrahydrobiopterin back to tetrahydrobiopterin,
CC       a cosubstrate for several enzymes, including aromatic amino acid
CC       hydroxylases.
CC   -!- The enzyme is bifunctional, and also acts as a dimerization cofactor
CC       of hepatocyte nuclear factor-1alpha (HNF-1).
DR   Q9LU63, ATP1_ARATH ;  Q6QJ72, PDL2_ARATH ;  Q475Y4, PHS1_CUPPJ ;
DR   Q7NM43, PHS1_GLOVI ;  Q9DG45, PHS2_CHICK ;  Q46VT8, PHS2_CUPPJ ;
DR   Q7NK35, PHS2_GLOVI ;  Q9H0N5, PHS2_HUMAN ;  Q9CZL5, PHS2_MOUSE ;
DR   Q5R7K1, PHS2_PONAB ;  C1F425, PHS_ACIC5  ;  A5FWK8, PHS_ACICJ  ;
DR   A0KJG4, PHS_AERHH  ;  A4SNJ1, PHS_AERS4  ;  B6JAT9, PHS_AFIC5  ;
DR   Q8UC22, PHS_AGRFC  ;  A6TVX6, PHS_ALKMQ  ;  B9JUA0, PHS_ALLAM  ;
DR   B4RXT2, PHS_ALTMD  ;  O66462, PHS_AQUAE  ;  Q5P905, PHS_AROAE  ;
DR   A1K7V8, PHS_AZOSB  ;  C1DQH9, PHS_AZOVD  ;  P61732, PHS_BDEBA  ;
DR   Q2KXB6, PHS_BORA1  ;  Q7WG14, PHS_BORBR  ;  Q7W4J0, PHS_BORPA  ;
DR   Q7VU17, PHS_BORPE  ;  Q3ZBD3, PHS_BOVIN  ;  Q89WZ6, PHS_BRADU  ;
DR   A5E8P9, PHS_BRASB  ;  A4YJY8, PHS_BRASO  ;  B2S7X9, PHS_BRUA1  ;
DR   Q2YNV0, PHS_BRUA2  ;  A6WV21, PHS_BRUA4  ;  Q57FT6, PHS_BRUAB  ;
DR   A9M6T4, PHS_BRUC2  ;  C0RGE2, PHS_BRUMB  ;  P65722, PHS_BRUME  ;
DR   A5VN26, PHS_BRUO2  ;  B0CIJ4, PHS_BRUSI  ;  P65723, PHS_BRUSU  ;
DR   B1YQ64, PHS_BURA4  ;  A0K2V4, PHS_BURCH  ;  B4E566, PHS_BURCJ  ;
DR   Q0BJP4, PHS_BURCM  ;  Q39L06, PHS_BURL3  ;  A9AJD5, PHS_BURM1  ;
DR   Q62FU4, PHS_BURMA  ;  B1K1I7, PHS_BURO0  ;  Q3JXT0, PHS_BURP1  ;
DR   Q63PF1, PHS_BURPS  ;  A4JA07, PHS_BURVG  ;  Q9TZH6, PHS_CAEEL  ;
DR   B0T207, PHS_CAUSK  ;  Q9ABI2, PHS_CAUVC  ;  B8GYB5, PHS_CAUVN  ;
DR   Q3IZF4, PHS_CERS4  ;  Q11D07, PHS_CHESB  ;  O73930, PHS_CHICK  ;
DR   A9WI69, PHS_CHLAA  ;  B8G3F7, PHS_CHLAD  ;  B3ECB9, PHS_CHLL2  ;
DR   Q3B6N5, PHS_CHLL3  ;  B3QQ83, PHS_CHLP8  ;  B9LCC8, PHS_CHLSY  ;
DR   Q8KFI4, PHS_CHLTE  ;  A0M1H4, PHS_CHRFK  ;  Q1QXY2, PHS_CHRSD  ;
DR   Q7NVH7, PHS_CHRVO  ;  Q47XN8, PHS_COLP3  ;  B8HU56, PHS_CYAP4  ;
DR   Q11PN9, PHS_CYTH3  ;  Q47IX1, PHS_DECAR  ;  Q54RY8, PHS_DICDI  ;
DR   A8LKP0, PHS_DINSH  ;  O76454, PHS_DROME  ;  P58249, PHS_DROVI  ;
DR   Q2SCE8, PHS_HAHCH  ;  A1WWH9, PHS_HALHL  ;  B9LPE3, PHS_HALLT  ;
DR   Q5V1I9, PHS_HALMA  ;  B0R6B9, PHS_HALS3  ;  Q9HP73, PHS_HALSA  ;
DR   A9AXS2, PHS_HERA2  ;  P61457, PHS_HUMAN  ;  Q31HZ6, PHS_HYDCU  ;
DR   P0C8L6, PHS_HYPEX  ;  Q5QU19, PHS_IDILO  ;  Q28VA7, PHS_JANSC  ;
DR   Q1IP68, PHS_KORVE  ;  Q5X3Q4, PHS_LEGPA  ;  A5IDI1, PHS_LEGPC  ;
DR   Q5ZU09, PHS_LEGPH  ;  Q5WV42, PHS_LEGPL  ;  A6VSD2, PHS_MARMS  ;
DR   A1TZA3, PHS_MARN8  ;  Q60BH8, PHS_METCA  ;  A4YEM3, PHS_METS5  ;
DR   B0JQV0, PHS_MICAN  ;  P61458, PHS_MOUSE  ;  A0QCA6, PHS_MYCA1  ;
DR   B1MLG8, PHS_MYCA9  ;  P0A5S3, PHS_MYCBO  ;  A1KHV0, PHS_MYCBP  ;
DR   C1AMF4, PHS_MYCBT  ;  B8ZRQ6, PHS_MYCLB  ;  Q9CBX1, PHS_MYCLE  ;
DR   P61733, PHS_MYCPA  ;  A0R2K7, PHS_MYCS2  ;  A3Q4G7, PHS_MYCSJ  ;
DR   A1UKF3, PHS_MYCSK  ;  Q1B4N5, PHS_MYCSS  ;  A5U1K8, PHS_MYCTA  ;
DR   P9WI92, PHS_MYCTO  ;  P9WI93, PHS_MYCTU  ;  A1TDS4, PHS_MYCVP  ;
DR   Q3ISB3, PHS_NATPD  ;  Q0ADS7, PHS_NITEC  ;  Q82Y13, PHS_NITEU  ;
DR   Q1QHE0, PHS_NITHX  ;  Q2YB52, PHS_NITMU  ;  Q3J910, PHS_NITOC  ;
DR   Q3SNS9, PHS_NITWN  ;  Q5YQC8, PHS_NOCFA  ;  B2IVV2, PHS_NOSP7  ;
DR   Q8YNL6, PHS_NOSS1  ;  Q2G9B0, PHS_NOVAD  ;  B1ZY08, PHS_OPITP  ;
DR   A1TND7, PHS_PARC0  ;  A1B3I3, PHS_PARDP  ;  A7HSX5, PHS_PARL1  ;
DR   Q7U5B3, PHS_PARMW  ;  B2T7M8, PHS_PARPJ  ;  Q13SM2, PHS_PARXL  ;
DR   B4SAU0, PHS_PELPB  ;  B4RBN1, PHS_PHEZH  ;  Q6LI45, PHS_PHOPR  ;
DR   B1XN71, PHS_PICP2  ;  A3PBL6, PHS_PROM0  ;  A8G3K7, PHS_PROM2  ;
DR   A2C7K4, PHS_PROM3  ;  A2BVF3, PHS_PROM5  ;  Q31C42, PHS_PROM9  ;
DR   Q7VD93, PHS_PROMA  ;  Q7V689, PHS_PROMM  ;  Q7V2I5, PHS_PROMP  ;
DR   A2BPX4, PHS_PROMS  ;  Q46GT1, PHS_PROMT  ;  Q48G05, PHS_PSE14  ;
DR   A6VAA4, PHS_PSEA7  ;  B7UY63, PHS_PSEA8  ;  Q02I31, PHS_PSEAB  ;
DR   P43335, PHS_PSEAE  ;  Q1I6Y2, PHS_PSEE4  ;  Q4KG97, PHS_PSEF5  ;
DR   C3K0W5, PHS_PSEFS  ;  A5W0C1, PHS_PSEP1  ;  Q3KG65, PHS_PSEPF  ;
DR   B0KRW3, PHS_PSEPG  ;  Q88EH2, PHS_PSEPK  ;  B1JCI6, PHS_PSEPW  ;
DR   Q885L1, PHS_PSESM  ;  Q3IIZ3, PHS_PSET1  ;  Q4ZQG4, PHS_PSEU2  ;
DR   Q4FVF3, PHS_PSYA2  ;  A1SSU3, PHS_PSYIN  ;  Q8XU38, PHS_RALN1  ;
DR   B2UGY6, PHS_RALPJ  ;  P61459, PHS_RAT    ;  Q2K3A7, PHS_RHIEC  ;
DR   Q1MAM8, PHS_RHIJ3  ;  Q98E92, PHS_RHILO  ;  B5ZTF5, PHS_RHILW  ;
DR   Q92L66, PHS_RHIME  ;  B9JCJ2, PHS_RHIR8  ;  A5V667, PHS_RHIWR  ;
DR   Q2J3Z9, PHS_RHOP2  ;  Q07N39, PHS_RHOP5  ;  P61734, PHS_RHOPA  ;
DR   Q214W1, PHS_RHOPB  ;  Q13D98, PHS_RHOPS  ;  B3Q9E4, PHS_RHOPT  ;
DR   Q2RNC0, PHS_RHORT  ;  A8GYB5, PHS_RICB8  ;  Q1RGM6, PHS_RICBR  ;
DR   A8EXY4, PHS_RICCK  ;  Q4UKS5, PHS_RICFE  ;  A7NS25, PHS_ROSCS  ;
DR   Q16BN1, PHS_ROSDO  ;  A5UPS5, PHS_ROSS1  ;  Q1AUE0, PHS_RUBXD  ;
DR   Q5LM31, PHS_RUEPO  ;  Q1GDR0, PHS_RUEST  ;  Q21MC6, PHS_SACD2  ;
DR   Q97WM6, PHS_SACS2  ;  O42658, PHS_SCHPO  ;  A1S7S0, PHS_SHEAM  ;
DR   B8E7N1, PHS_SHEB2  ;  A3D2P0, PHS_SHEB5  ;  A6WLE1, PHS_SHEB8  ;
DR   A9KVE9, PHS_SHEB9  ;  Q12L03, PHS_SHEDO  ;  Q084Y3, PHS_SHEFN  ;
DR   B0TNB2, PHS_SHEHH  ;  A3QCV5, PHS_SHELP  ;  Q8EGD7, PHS_SHEON  ;
DR   A8H2I7, PHS_SHEPA  ;  A4Y581, PHS_SHEPC  ;  B8CLA1, PHS_SHEPW  ;
DR   A0KYY8, PHS_SHESA  ;  Q0HGZ0, PHS_SHESM  ;  Q0HT97, PHS_SHESR  ;
DR   A1RLI8, PHS_SHESW  ;  B1KMK3, PHS_SHEWM  ;  C3MAI8, PHS_SINFN  ;
DR   A6UE17, PHS_SINMW  ;  Q01VX3, PHS_SOLUE  ;  Q82M02, PHS_STRAW  ;
DR   O86722, PHS_STRCO  ;  B4SPV4, PHS_STRM5  ;  B2FM88, PHS_STRMK  ;
DR   A4VQE0, PHS_STUS1  ;  Q4J6J6, PHS_SULAC  ;  C3MZU9, PHS_SULIA  ;
DR   C4KJC1, PHS_SULIK  ;  C3MTL3, PHS_SULIM  ;  Q96YL0, PHS_SULTO  ;
DR   Q3A282, PHS_SYNC1  ;  A5GMR6, PHS_SYNPW  ;  Q0I8H5, PHS_SYNS3  ;
DR   P73790, PHS_SYNY3  ;  B9L1Y8, PHS_THERP  ;  Q8DHW8, PHS_THEVB  ;
DR   Q3SHT9, PHS_THIDA  ;  Q116J2, PHS_TRIEI  ;  Q3MA60, PHS_TRIV2  ;
DR   A7N3S9, PHS_VIBC1  ;  A5F0J0, PHS_VIBC3  ;  Q9KLB9, PHS_VIBCH  ;
DR   C3LW91, PHS_VIBCM  ;  Q87IM9, PHS_VIBPA  ;  Q8D6S1, PHS_VIBVU  ;
DR   Q7MDN2, PHS_VIBVY  ;  Q8PKQ3, PHS_XANAC  ;  Q3BSV4, PHS_XANC5  ;
DR   Q4UUW5, PHS_XANC8  ;  B0RTH5, PHS_XANCB  ;  Q8P8Z8, PHS_XANCP  ;
DR   Q2P1A2, PHS_XANOM  ;  B2STN6, PHS_XANOP  ;  Q5GYA0, PHS_XANOR  ;
DR   Q91901, PHS_XENLA  ;  B2I9W6, PHS_XYLF2  ;  Q9PAB4, PHS_XYLFA  ;
DR   B0U5V4, PHS_XYLFM  ;  Q87A51, PHS_XYLFT  ;  P38744, PHS_YEAST  ;
//