ID 4.2.2.5 DE chondroitin AC lyase. AN chondroitin AC eliminase. AN chondroitinase. AN chondroitin sulfate lyase. CA Eliminative degradation of polysaccharides containing 1,4-beta-D- CA hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides CA containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. CC -!- Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less CC well on hyaluronate. CC -!- In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains CC comprise a linkage region, a chain cap and a repeat region. CC -!- The repeat region of CS is a repeating disaccharide of glucuronic CC acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1- CC 3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of CC GalNAc and C-2 of GlcA. CC -!- GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming CC the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. CC -!- Both the concentrations and locations of sulfate-ester substituents CC vary with glucosaminoglycan source. CC -!- Formerly EC 4.2.99.6. DR Q59288, CSLA_PEDHD ; //