ID   4.2.3.108
DE   1,8-cineole synthase.
AN   1,8-cineole cyclase.
CA   (2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate.
CC   -!- 1,8-cineole is the main product from the enzyme with just traces of
CC       other monoterpenoids.
CC   -!- The oxygen atom is derived from water.
CC   -!- The reaction proceeds via linalyl diphosphate and alpha-terpineol,
CC       the stereochemistry of both depends on the organism.
CC   -!- However neither intermediate can substitute for geranyl diphosphate.
CC   -!- The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-
CC       linalyl diphosphate while that in Arabidopsis (rock cress) proceeds
CC       via (+)-(3S)-linalyl diphosphate.
DR   R9QMZ0, ATERP_PINCO;  P0DI76, CIN1_ARATH ;  P0DI77, CIN2_ARATH ;
DR   F2XFA2, CINES_PICGL;  C0PT35, CINES_PICSI;  F2XF98, CINES_PICXS;
DR   A6XH05, CINS1_SALFT;  A5Y5L5, CIN_NICSU  ;  B5GMG2, CNSA_STRCL ;
DR   O81191, SCS_SALOF  ;  H6WZF2, TER_NICAL  ;  H2ELN1, TER_NICLA  ;
//