ID 4.2.3.12 DE 6-pyruvoyltetrahydropterin synthase. AN 6-pyruvoyl tetrahydrobiopterin synthase. AN PTPS. CA 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- CA tetrahydropterin + H(+) + triphosphate. CC -!- Catalyzes triphosphate elimination and an intramolecular redox CC reaction. CC -!- The product is 6-pyruvoyltetrahydrobiopterin. CC -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, CC with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16. CC -!- Formerly EC 4.6.1.10. DR O02058, PTPS_CAEEL ; Q1ZXI0, PTPS_DICDI ; P48611, PTPS_DROME ; DR Q03393, PTPS_HUMAN ; Q9R1Z7, PTPS_MOUSE ; Q90W95, PTPS_POERE ; DR Q5REZ5, PTPS_PONAB ; P27213, PTPS_RAT ; P80081, PTPS_SALSA ; //