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ENZYME entry: EC 4.2.3.141

Accepted Name
Sclareol synthase.
Reaction catalysed
(13E)-8-alpha-hydroxylabd-13-en-15-yl diphosphate + H(2)O <=> sclareol + diphosphate
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • Isolated from the plant Salvia sclarea (clary sage).
  • Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133 and EC 4.2.3.141.
  • Sclareol is used in perfumery.
  • Formerly EC 3.1.7.4.
Cross-references
BRENDA4.2.3.141
EC2PDB4.2.3.141
ExplorEnz4.2.3.141
PRIAM enzyme-specific profiles4.2.3.141
KEGG Ligand Database for Enzyme Nomenclature4.2.3.141
IUBMB Enzyme Nomenclature4.2.3.141
IntEnz4.2.3.141
MEDLINEFind literature relating to 4.2.3.141
MetaCyc4.2.3.141
UniProtKB/Swiss-Prot
G8GJ94, SCLS_SALSC

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