ID 4.2.3.149 DE nephthenol synthase. CA (2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + CA diphosphate. CC -!- Two isozymes with this activity were isolated from the bacterium CC Streptomyces sp. SANK 60404. CC -!- The enzyme encoded by the DtcycA gene also produces cembrene C (see CC 4.2.3.148), while the enzyme encoded by the DtcycB gene also produces CC (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13- CC pentamethylcyclopentadeca-4,8,12-trien-1-ol (cf. EC 4.2.3.150 and CC EC 4.2.3.151). DR M1V9Q0, DTCYA_STRSQ; M1VDX3, DTCYB_STRSQ; //