ID 4.2.3.17 DE taxadiene synthase. AN taxa-4(5),11(12)-diene synthase. AN taxadiene cyclase. CA (2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. CC -!- This is the committed step in the biosynthesis of the diterpenoid CC antineoplastic drug Taxol (paclitaxel). CC -!- The cyclization involves a 1,5-hydride shift. DR Q93YA3, TASY_TAXBA ; Q41594, TASY_TAXBR ; Q9FT37, TASY_TAXCH ; //