ID 4.2.3.22 DE germacradienol synthase. AN germacradienol/germacrene-D synthase. CA (2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien- CA 11-ol + diphosphate. CC -!- H-1si of farnesyl diphosphate is lost in the formation of CC (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. CC -!- Formation of (-)-germacrene D involves a stereospecific 1,3-hydride CC shift of H-1si of farnesyl diphosphate. CC -!- Both products are formed from a common intermediate. CC -!- The enzyme mediates a key step in the biosynthesis of geosmin (see CC EC 4.1.99.16), a widely occurring metabolite of many streptomycetes, CC bacteria and fungi. CC -!- Also catalyzes the reaction of EC 4.2.3.75. DR Q9X839, CYC2_STRCO ; Q6Q3H3, TPSGD_VITVI; //