ID   4.3.2.10
DE   imidazole glycerol-phosphate synthase.
AN   IGP synthase.
CA   5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-
CA   D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-
CA   beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-
CA   yl)glycerol 3-phosphate + H(+) + L-glutamate.
CC   -!- The enzyme is involved in histidine biosynthesis, as well as purine
CC       nucleotide biosynthesis.
CC   -!- The enzymes from archaea and bacteria are heterodimeric.
CC   -!- A glutaminase component (cf. EC 3.5.1.2) produces an ammonia molecule
CC       that is transferred by a 25 A tunnel to a cyclase component, which
CC       adds it to the imidazole ring, leading to lysis of the molecule and
CC       cyclization of one of the products.
CC   -!- The glutminase subunit is only active within the dimeric complex.
CC   -!- In fungi and plants the two subunits are combined into a single
CC       polypeptide.
DR   Q9SZ30, HIS4_ARATH ;  Q0P8U2, HIS51_CAMJE;  A1W0U9, HIS51_CAMJJ;
DR   Q5HT90, HIS51_CAMJR;  Q5X6Z7, HIS51_LEGPA;  Q5ZXI1, HIS51_LEGPH;
DR   Q5WYE9, HIS51_LEGPL;  P61782, HIS51_METMP;  Q3SWE9, HIS51_NITWN;
DR   Q7U924, HIS51_PARMW;  Q7V959, HIS51_PROMM;  Q9HU42, HIS51_PSEAE;
DR   Q7MLS3, HIS51_VIBVY;  Q9PM75, HIS52_CAMJE;  Q5HSJ1, HIS52_CAMJR;
DR   Q5X5X2, HIS52_LEGPA;  Q5ZW90, HIS52_LEGPH;  Q5WX94, HIS52_LEGPL;
DR   P61783, HIS52_METMP;  Q3SPZ6, HIS52_NITWN;  Q7U899, HIS52_PARMW;
DR   Q7V6M5, HIS52_PROMM;  P72138, HIS52_PSEAE;  Q7MPP4, HIS52_VIBVY;
DR   Q7MPK8, HIS53_VIBVY;  B0BYP8, HIS5_ACAM1 ;  Q6F7A7, HIS5_ACIAD ;
DR   P58788, HIS5_AGRFC ;  Q5E635, HIS5_ALIF1 ;  O66943, HIS5_AQUAE ;
DR   O28019, HIS5_ARCFU ;  Q5P793, HIS5_AROAE ;  P18785, HIS5_AZOBR ;
DR   C3P504, HIS5_BACAA ;  C3L9P9, HIS5_BACAC ;  A0RBM0, HIS5_BACAH ;
DR   Q81T60, HIS5_BACAN ;  B7JFZ3, HIS5_BACC0 ;  P61778, HIS5_BACC1 ;
DR   B7INA1, HIS5_BACC2 ;  C1EMQ5, HIS5_BACC3 ;  B7HHG3, HIS5_BACC4 ;
DR   B7HKD2, HIS5_BACC7 ;  A7GMU8, HIS5_BACCN ;  B9IUZ8, HIS5_BACCQ ;
DR   Q81G04, HIS5_BACCR ;  Q63DX0, HIS5_BACCZ ;  Q5LBD5, HIS5_BACFN ;
DR   Q64RT0, HIS5_BACFR ;  Q6HLE5, HIS5_BACHK ;  Q65EG1, HIS5_BACLD ;
DR   A9VLH5, HIS5_BACMK ;  A8FHR1, HIS5_BACP2 ;  O34565, HIS5_BACSU ;
DR   Q8A7Z4, HIS5_BACTN ;  A7Z964, HIS5_BACVZ ;  P60597, HIS5_BDEBA ;
DR   Q8G4S6, HIS5_BIFLO ;  Q7VQW7, HIS5_BLOFL ;  Q492K0, HIS5_BLOPB ;
DR   Q7WDY1, HIS5_BORBR ;  Q7W2Y1, HIS5_BORPA ;  Q7VSY8, HIS5_BORPE ;
DR   Q89WM6, HIS5_BRADU ;  Q2YQZ0, HIS5_BRUA2 ;  Q57AH5, HIS5_BRUAB ;
DR   Q8YE35, HIS5_BRUME ;  Q8FY09, HIS5_BRUSU ;  P57204, HIS5_BUCAI ;
DR   Q9ZHE3, HIS5_BUCAP ;  P59501, HIS5_BUCBP ;  Q84I56, HIS5_BUCDN ;
DR   Q84I55, HIS5_BUCMH ;  Q84I54, HIS5_BUCSC ;  Q39K87, HIS5_BURL3 ;
DR   Q845U9, HIS5_BURM1 ;  Q62GE3, HIS5_BURMA ;  Q3JN00, HIS5_BURP1 ;
DR   Q63Q90, HIS5_BURPS ;  Q8R883, HIS5_CALS4 ;  Q3AD50, HIS5_CARHZ ;
DR   Q9A231, HIS5_CAUVC ;  O33565, HIS5_CERS4 ;  A9WD25, HIS5_CHLAA ;
DR   B8G9S3, HIS5_CHLAD ;  Q3AT63, HIS5_CHLCH ;  Q3B286, HIS5_CHLL3 ;
DR   B9LI74, HIS5_CHLSY ;  Q8KF56, HIS5_CHLTE ;  Q7P0F1, HIS5_CHRVO ;
DR   Q97KI0, HIS5_CLOAB ;  Q47XB5, HIS5_COLP3 ;  P60598, HIS5_CORDI ;
DR   Q8FNZ6, HIS5_COREF ;  O69043, HIS5_CORGL ;  Q4JW55, HIS5_CORJK ;
DR   Q46WL6, HIS5_CUPPJ ;  Q6A8L2, HIS5_CUTAK ;  Q9TLQ8, HIS5_CYACA ;
DR   Q85FY4, HIS5_CYAM1 ;  B8HUR1, HIS5_CYAP4 ;  P48262, HIS5_CYAPA ;
DR   Q47AM1, HIS5_DECAR ;  Q3Z7F2, HIS5_DEHM1 ;  Q3ZY50, HIS5_DEHMC ;
DR   Q9RX89, HIS5_DEIRA ;  B8J215, HIS5_DESDA ;  B8FP22, HIS5_DESHD ;
DR   Q24QJ3, HIS5_DESHY ;  P61779, HIS5_DESVH ;  B8DQX7, HIS5_DESVM ;
DR   A1VGZ0, HIS5_DESVV ;  P58237, HIS5_ECO57 ;  P60596, HIS5_ECOL6 ;
DR   P60595, HIS5_ECOLI ;  Q9P4P9, HIS5_EMENI ;  B1YL11, HIS5_EXIS2 ;
DR   Q5KVC8, HIS5_GEOKA ;  Q39YP4, HIS5_GEOMG ;  P60599, HIS5_GEOSL ;
DR   C5D7P0, HIS5_GEOSW ;  A4ISR4, HIS5_GEOTN ;  B7KGN3, HIS5_GLOC7 ;
DR   Q7NNK4, HIS5_GLOVI ;  Q5FTN5, HIS5_GLUOX ;  Q0BPX1, HIS5_GRABC ;
DR   Q4QN71, HIS5_HAEI8 ;  P44340, HIS5_HAEIN ;  Q9K6Z4, HIS5_HALH5 ;
DR   Q5UYV3, HIS5_HALMA ;  Q9HNI6, HIS5_HALSA ;  Q7VIW9, HIS5_HELHP ;
DR   A9B5I2, HIS5_HERA2 ;  Q31E66, HIS5_HYDCU ;  Q5QWQ7, HIS5_IDILO ;
DR   B3WED3, HIS5_LACCB ;  Q02132, HIS5_LACLA ;  Q039B3, HIS5_LACP3 ;
DR   Q88UE1, HIS5_LACPL ;  Q9RDX3, HIS5_LEGPN ;  Q6AE14, HIS5_LEIXX ;
DR   Q9ZGM1, HIS5_LEPBO ;  P61780, HIS5_LEPIC ;  P59118, HIS5_LEPIN ;
DR   Q9S4H8, HIS5_LEPIR ;  Q92E86, HIS5_LISIN ;  C1L0J4, HIS5_LISMC ;
DR   Q722Y5, HIS5_LISMF ;  B8DA60, HIS5_LISMH ;  Q8Y9G3, HIS5_LISMO ;
DR   A0AG17, HIS5_LISW6 ;  Q65RB8, HIS5_MANSM ;  C6C1X6, HIS5_MARSD ;
DR   Q8TS91, HIS5_METAC ;  Q465U3, HIS5_METBF ;  Q603K1, HIS5_METCA ;
DR   Q57929, HIS5_METJA ;  Q8TV83, HIS5_METKA ;  Q8PVD5, HIS5_METMA ;
DR   O27568, HIS5_METTH ;  B0JFQ9, HIS5_MICAN ;  Q2RGW0, HIS5_MOOTA ;
DR   P59957, HIS5_MYCBO ;  Q9X7C0, HIS5_MYCLE ;  P60600, HIS5_MYCPA ;
DR   P9WMM0, HIS5_MYCTO ;  P9WMM1, HIS5_MYCTU ;  Q3IUP8, HIS5_NATPD ;
DR   Q5FA21, HIS5_NEIG1 ;  Q9JVH3, HIS5_NEIMA ;  Q9K0H2, HIS5_NEIMB ;
DR   Q820D2, HIS5_NITEU ;  Q2YAU8, HIS5_NITMU ;  Q3J6Q3, HIS5_NITOC ;
DR   Q5YYP7, HIS5_NOCFA ;  B2J1A3, HIS5_NOSP7 ;  Q8YX49, HIS5_NOSS1 ;
DR   Q8ESS0, HIS5_OCEIH ;  Q316L3, HIS5_OLEA2 ;  P57921, HIS5_PASMU ;
DR   Q6D408, HIS5_PECAS ;  Q4FNT5, HIS5_PELUB ;  Q7N6I3, HIS5_PHOLL ;
DR   P62448, HIS5_PHOPR ;  Q6KZD3, HIS5_PICTO ;  A9BB49, HIS5_PROM4 ;
DR   Q31AG5, HIS5_PROM9 ;  Q7VBF5, HIS5_PROMA ;  Q7V127, HIS5_PROMP ;
DR   Q46JZ5, HIS5_PROMT ;  Q48C78, HIS5_PSE14 ;  Q4KJS7, HIS5_PSEF5 ;
DR   Q3KJI8, HIS5_PSEPF ;  Q88R44, HIS5_PSEPK ;  Q87UG1, HIS5_PSESM ;
DR   Q4ZLP9, HIS5_PSEU2 ;  Q4FPU1, HIS5_PSYA2 ;  Q8ZY40, HIS5_PYRAE ;
DR   P58789, HIS5_PYRFU ;  Q8XV83, HIS5_RALN1 ;  A9WQ58, HIS5_RENSM ;
DR   Q98CT5, HIS5_RHILO ;  Q92TB1, HIS5_RHIME ;  Q7ULP3, HIS5_RHOBA ;
DR   P60601, HIS5_RHOPA ;  Q2RNA5, HIS5_RHORT ;  Q5LU93, HIS5_RUEPO ;
DR   O33777, HIS5_SACS2 ;  Q57MS0, HIS5_SALCH ;  Q5PDP6, HIS5_SALPA ;
DR   Q2S299, HIS5_SALRD ;  P0A1R5, HIS5_SALTI ;  P0A1R4, HIS5_SALTY ;
DR   O94303, HIS5_SCHPO ;  A3QF19, HIS5_SHELP ;  Q8EFB4, HIS5_SHEON ;
DR   A8FWC9, HIS5_SHESH ;  Q323I9, HIS5_SHIBS ;  Q32EF2, HIS5_SHIDS ;
DR   Q83KJ5, HIS5_SHIFL ;  Q3Z0G2, HIS5_SHISS ;  Q5WDI0, HIS5_SHOC1 ;
DR   Q2YZ69, HIS5_STAAB ;  Q5HCM2, HIS5_STAAC ;  P64363, HIS5_STAAM ;
DR   P64364, HIS5_STAAN ;  Q6GDC9, HIS5_STAAR ;  Q6G600, HIS5_STAAS ;
DR   P64365, HIS5_STAAW ;  Q5HKP0, HIS5_STAEQ ;  Q8CTV0, HIS5_STAES ;
DR   Q4A047, HIS5_STAS1 ;  Q82AA2, HIS5_STRAW ;  P16249, HIS5_STRCO ;
DR   A8AY26, HIS5_STRGC ;  Q8DTR1, HIS5_STRMU ;  A3CNT2, HIS5_STRSV ;
DR   Q4J8I5, HIS5_SULAC ;  Q30PY0, HIS5_SULDN ;  Q970Y7, HIS5_SULTO ;
DR   Q67KH8, HIS5_SYMTH ;  Q3A135, HIS5_SYNC1 ;  Q31N58, HIS5_SYNE7 ;
DR   Q2JVR1, HIS5_SYNJA ;  Q2JN09, HIS5_SYNJB ;  Q5MZ63, HIS5_SYNP6 ;
DR   Q3AYZ0, HIS5_SYNS9 ;  Q3AI95, HIS5_SYNSC ;  Q55805, HIS5_SYNY3 ;
DR   Q47QS5, HIS5_THEFY ;  Q5JFV0, HIS5_THEKO ;  Q9X0C8, HIS5_THEMA ;
DR   P61781, HIS5_THET2 ;  Q7SIC0, HIS5_THET8 ;  Q8DIP5, HIS5_THEVB ;
DR   Q3SEU6, HIS5_THIDA ;  Q113E7, HIS5_TRIEI ;  Q3M5W4, HIS5_TRIV2 ;
DR   Q9KSX0, HIS5_VIBCH ;  Q87QK8, HIS5_VIBPA ;  Q8D8Q3, HIS5_VIBVU ;
DR   Q7M9X0, HIS5_WOLSU ;  Q8PLG8, HIS5_XANAC ;  Q3BUF4, HIS5_XANC5 ;
DR   Q4UU43, HIS5_XANC8 ;  Q8P9P1, HIS5_XANCP ;  Q2P3K0, HIS5_XANOM ;
DR   Q5H0K8, HIS5_XANOR ;  Q9PBC8, HIS5_XYLFA ;  Q87C32, HIS5_XYLFT ;
DR   P33734, HIS5_YEAST ;  Q8ZFX8, HIS5_YERPE ;  Q66C52, HIS5_YERPS ;
DR   Q5NMD4, HIS5_ZYMMO ;  Q9PM72, HIS61_CAMJE;  Q7U5M8, HIS61_PARMW;
DR   Q7V8Q8, HIS61_PROMM;  Q9HU44, HIS61_PSEAE;  Q7MLS1, HIS61_VIBVY;
DR   Q0P8U3, HIS62_CAMJE;  A1W0U8, HIS62_CAMJJ;  Q7U923, HIS62_PARMW;
DR   Q7V958, HIS62_PROMM;  P72139, HIS62_PSEAE;  Q7MPP3, HIS62_VIBVY;
DR   Q7MPK7, HIS63_VIBVY;  A3DJF7, HIS6_ACET2 ;  Q6F799, HIS6_ACIAD ;
DR   B7GVJ5, HIS6_ACIB3 ;  B7IBD7, HIS6_ACIB5 ;  B2I0P3, HIS6_ACIBC ;
DR   A3M9P1, HIS6_ACIBT ;  C1FAD8, HIS6_ACIC5 ;  A5FYE5, HIS6_ACICJ ;
DR   B9MDW3, HIS6_ACIET ;  B7JA19, HIS6_ACIF2 ;  B5EQF2, HIS6_ACIF5 ;
DR   A1W444, HIS6_ACISJ ;  B3GZH3, HIS6_ACTP7 ;  A6VQ74, HIS6_ACTSZ ;
DR   A0KKB0, HIS6_AERHH ;  A4SMQ4, HIS6_AERS4 ;  B6JCG5, HIS6_AFIC5 ;
DR   P58799, HIS6_AGRFC ;  B2UQA2, HIS6_AKKM8 ;  Q21U91, HIS6_ALBFT ;
DR   Q0VM72, HIS6_ALCBS ;  A8EQW5, HIS6_ALIB4 ;  Q5E633, HIS6_ALIF1 ;
DR   B5FDA4, HIS6_ALIFM ;  B6EJ93, HIS6_ALISL ;  Q0A5D3, HIS6_ALKEH ;
DR   A6TKT6, HIS6_ALKMQ ;  B4RU62, HIS6_ALTMD ;  B7GL45, HIS6_ANOFW ;
DR   O66567, HIS6_AQUAE ;  O29439, HIS6_ARCFU ;  Q5P795, HIS6_AROAE ;
DR   A0JVK5, HIS6_ARTS2 ;  P26721, HIS6_AZOBR ;  A8HYT7, HIS6_AZOC5 ;
DR   B6YQ30, HIS6_AZOPC ;  A1KAV4, HIS6_AZOSB ;  C1DJD3, HIS6_AZOVD ;
DR   C3P506, HIS6_BACAA ;  C3L9P7, HIS6_BACAC ;  A0RBM2, HIS6_BACAH ;
DR   Q81T58, HIS6_BACAN ;  B7JFZ5, HIS6_BACC0 ;  P62449, HIS6_BACC1 ;
DR   B7INA3, HIS6_BACC2 ;  C1EMQ7, HIS6_BACC3 ;  B7HHG5, HIS6_BACC4 ;
DR   B7HKD4, HIS6_BACC7 ;  A7GMV0, HIS6_BACCN ;  B9IV00, HIS6_BACCQ ;
DR   Q81G02, HIS6_BACCR ;  Q63DW8, HIS6_BACCZ ;  Q5LBD7, HIS6_BACFN ;
DR   Q64RT2, HIS6_BACFR ;  Q6HLE3, HIS6_BACHK ;  Q65EG3, HIS6_BACLD ;
DR   A9VLH7, HIS6_BACMK ;  A8FHQ9, HIS6_BACP2 ;  O34727, HIS6_BACSU ;
DR   Q8A7Z6, HIS6_BACTN ;  A7Z962, HIS6_BACVZ ;  Q1LT72, HIS6_BAUCH ;
DR   B2ICL0, HIS6_BEII9 ;  C5BV99, HIS6_BEUC1 ;  B8DUB2, HIS6_BIFA0 ;
DR   A1A1I5, HIS6_BIFAA ;  B3DRT8, HIS6_BIFLD ;  Q8G6F7, HIS6_BIFLO ;
DR   B7GQS5, HIS6_BIFLS ;  Q7VQW5, HIS6_BLOFL ;  Q494D6, HIS6_BLOPB ;
DR   Q2KTT1, HIS6_BORA1 ;  Q7WDX9, HIS6_BORBR ;  Q7W2X9, HIS6_BORPA ;
DR   Q7VSY6, HIS6_BORPE ;  Q89WM4, HIS6_BRADU ;  A5E8E5, HIS6_BRASB ;
DR   A4YJV5, HIS6_BRASO ;  C0Z6P4, HIS6_BREBN ;  B2S984, HIS6_BRUA1 ;
DR   Q2YQY8, HIS6_BRUA2 ;  A6WX52, HIS6_BRUA4 ;  Q57AH3, HIS6_BRUAB ;
DR   A9M9R9, HIS6_BRUC2 ;  C0RFX3, HIS6_BRUMB ;  Q8YE37, HIS6_BRUME ;
DR   A5VT43, HIS6_BRUO2 ;  B0CJI6, HIS6_BRUSI ;  Q8FY07, HIS6_BRUSU ;
DR   P57206, HIS6_BUCAI ;  Q9ZHE1, HIS6_BUCAP ;  P59521, HIS6_BUCBP ;
DR   B1YRW1, HIS6_BURA4 ;  A0K3V8, HIS6_BURCH ;  B4E641, HIS6_BURCJ ;
DR   Q0BIW4, HIS6_BURCM ;  Q39K85, HIS6_BURL3 ;  Q845U7, HIS6_BURM1 ;
DR   A3MPU4, HIS6_BURM7 ;  A2S754, HIS6_BURM9 ;  Q62GE5, HIS6_BURMA ;
DR   A1V8H5, HIS6_BURMS ;  B1JUA5, HIS6_BURO0 ;  Q1BS31, HIS6_BURO1 ;
DR   A3P027, HIS6_BURP0 ;  Q3JN02, HIS6_BURP1 ;  A3NE93, HIS6_BURP6 ;
DR   Q63Q92, HIS6_BURPS ;  Q2SUA8, HIS6_BURTA ;  A4JAW9, HIS6_BURVG ;
DR   Q8R885, HIS6_CALS4 ;  A7ZGB2, HIS6_CAMC1 ;  A7GVW5, HIS6_CAMC5 ;
DR   A0RRT8, HIS6_CAMFF ;  A7I416, HIS6_CAMHC ;  A8FNR4, HIS6_CAMJ8 ;
DR   A7H5V4, HIS6_CAMJD ;  Q5HSI8, HIS6_CAMJR ;  B9KEI4, HIS6_CAMLR ;
DR   Q3AD48, HIS6_CARHZ ;  B0T798, HIS6_CAUSK ;  Q9A229, HIS6_CAUVC ;
DR   B8GW15, HIS6_CAUVN ;  B3PGA4, HIS6_CELJU ;  A3PI62, HIS6_CERS1 ;
DR   P50937, HIS6_CERS4 ;  A4WUS8, HIS6_CERS5 ;  B9KPC8, HIS6_CERSK ;
DR   Q11CK7, HIS6_CHESB ;  A9WD80, HIS6_CHLAA ;  B8GBF3, HIS6_CHLAD ;
DR   Q3ATG0, HIS6_CHLCH ;  B3EEF2, HIS6_CHLL2 ;  Q3B2Q6, HIS6_CHLL3 ;
DR   B3QQ00, HIS6_CHLP8 ;  B3EKW7, HIS6_CHLPB ;  A1BHP6, HIS6_CHLPD ;
DR   A4SFU1, HIS6_CHLPM ;  B9LFN2, HIS6_CHLSY ;  B3QSI0, HIS6_CHLT3 ;
DR   Q8KCB0, HIS6_CHLTE ;  A0M283, HIS6_CHRFK ;  Q1R080, HIS6_CHRSD ;
DR   Q7P0E9, HIS6_CHRVO ;  B5EDR4, HIS6_CITBB ;  A8AEJ9, HIS6_CITK8 ;
DR   A5CRW2, HIS6_CLAM3 ;  Q97KH8, HIS6_CLOAB ;  A7FU82, HIS6_CLOB1 ;
DR   C3KVX6, HIS6_CLOB6 ;  A6LT22, HIS6_CLOB8 ;  B2UX20, HIS6_CLOBA ;
DR   A5I246, HIS6_CLOBH ;  C1FN42, HIS6_CLOBJ ;  B1ILB0, HIS6_CLOBK ;
DR   A7GDQ7, HIS6_CLOBL ;  Q18C74, HIS6_CLOD6 ;  Q47XB3, HIS6_COLP3 ;
DR   C3PHA6, HIS6_CORA7 ;  P60714, HIS6_CORDI ;  Q8FNZ9, HIS6_COREF ;
DR   A4QFF9, HIS6_CORGB ;  O31139, HIS6_CORGL ;  Q4JW52, HIS6_CORJK ;
DR   B1VH88, HIS6_CORU7 ;  A7MHE1, HIS6_CROS8 ;  Q1LIB2, HIS6_CUPMC ;
DR   Q0K693, HIS6_CUPNH ;  Q46WL8, HIS6_CUPPJ ;  B3R794, HIS6_CUPTR ;
DR   Q6A7Y8, HIS6_CUTAK ;  Q11VM1, HIS6_CYTH3 ;  Q47AM3, HIS6_DECAR ;
DR   Q3Z7F5, HIS6_DEHM1 ;  A5FQI9, HIS6_DEHMB ;  Q3ZY29, HIS6_DEHMC ;
DR   Q1IX39, HIS6_DEIGD ;  Q9RWD7, HIS6_DEIRA ;  A9BXA1, HIS6_DELAS ;
DR   C0Q9D3, HIS6_DESAH ;  B8FFL4, HIS6_DESAL ;  B1I556, HIS6_DESAP ;
DR   B8J216, HIS6_DESDA ;  B8FP24, HIS6_DESHD ;  Q24QJ5, HIS6_DESHY ;
DR   A8ZVD2, HIS6_DESOH ;  A4J707, HIS6_DESRM ;  P62450, HIS6_DESVH ;
DR   B8DQX6, HIS6_DESVM ;  A1VGY9, HIS6_DESVV ;  B5YE90, HIS6_DICT6 ;
DR   B8E2C8, HIS6_DICTD ;  A8LHX5, HIS6_DINSH ;  A7ZNJ7, HIS6_ECO24 ;
DR   B7UT62, HIS6_ECO27 ;  B7MDH9, HIS6_ECO45 ;  B7L9Q2, HIS6_ECO55 ;
DR   P60665, HIS6_ECO57 ;  B5YU81, HIS6_ECO5E ;  B7NQG5, HIS6_ECO7I ;
DR   B7MWU3, HIS6_ECO81 ;  B7M404, HIS6_ECO8A ;  C4ZSB4, HIS6_ECOBW ;
DR   B1X6W2, HIS6_ECODH ;  A8A1P9, HIS6_ECOHS ;  A1ACN7, HIS6_ECOK1 ;
DR   Q0TG62, HIS6_ECOL5 ;  Q8FG48, HIS6_ECOL6 ;  B1IZ49, HIS6_ECOLC ;
DR   P60664, HIS6_ECOLI ;  B7NC65, HIS6_ECOLU ;  B6I896, HIS6_ECOSE ;
DR   B1LP16, HIS6_ECOSM ;  Q1RA48, HIS6_ECOUT ;  C5BG16, HIS6_EDWI9 ;
DR   B2KEU8, HIS6_ELUMP ;  B1H0E6, HIS6_ENDTX ;  A4WC74, HIS6_ENT38 ;
DR   B7LUF6, HIS6_ESCF3 ;  B1YL09, HIS6_EXIS2 ;  C4L176, HIS6_EXISA ;
DR   A5FFX6, HIS6_FLAJ1 ;  A6GY75, HIS6_FLAPJ ;  Q2J8L3, HIS6_FRACC ;
DR   B0TY41, HIS6_FRAP2 ;  B9M0M0, HIS6_GEODF ;  Q5KVD0, HIS6_GEOKA ;
DR   Q39YP2, HIS6_GEOMG ;  P60715, HIS6_GEOSL ;  C6E7F4, HIS6_GEOSM ;
DR   C5D7N8, HIS6_GEOSW ;  A4ISR2, HIS6_GEOTN ;  A5G8S9, HIS6_GEOUR ;
DR   Q7NDC1, HIS6_GLOVI ;  A9GZW9, HIS6_GLUDA ;  Q5FTN3, HIS6_GLUOX ;
DR   Q4QN69, HIS6_HAEI8 ;  A5UA15, HIS6_HAEIE ;  P44436, HIS6_HAEIN ;
DR   Q2SMB2, HIS6_HAHCH ;  Q9K6Z6, HIS6_HALH5 ;  A1WW05, HIS6_HALHL ;
DR   Q5V2C9, HIS6_HALMA ;  B8D116, HIS6_HALOH ;  B0R4B2, HIS6_HALS3 ;
DR   Q9HR52, HIS6_HALSA ;  Q18JI3, HIS6_HALWD ;  Q7VGZ1, HIS6_HELHP ;
DR   B0TDM7, HIS6_HELMI ;  Q8GDQ6, HIS6_HELMO ;  A9B5I5, HIS6_HERA2 ;
DR   A4G9I6, HIS6_HERAR ;  Q31E64, HIS6_HYDCU ;  B4U7M4, HIS6_HYDS0 ;
DR   Q0C643, HIS6_HYPNA ;  Q5QWQ5, HIS6_IDILO ;  A8AAK3, HIS6_IGNH4 ;
DR   A6T376, HIS6_JANMA ;  Q28NK0, HIS6_JANSC ;  A6WC96, HIS6_KINRD ;
DR   P45603, HIS6_KLEOX ;  B5XPE2, HIS6_KLEP3 ;  A6TBC8, HIS6_KLEP7 ;
DR   B2GGU9, HIS6_KOCRD ;  Q1IKB2, HIS6_KORVE ;  B3WED1, HIS6_LACCB ;
DR   Q02133, HIS6_LACLA ;  A2RKR7, HIS6_LACLM ;  Q02YX1, HIS6_LACLS ;
DR   Q039B5, HIS6_LACP3 ;  A9KP30, HIS6_LACP7 ;  Q88UE3, HIS6_LACPL ;
DR   C1DAK5, HIS6_LARHH ;  Q9RDX2, HIS6_LEGPN ;  Q6AF73, HIS6_LEIXX ;
DR   B0S8V2, HIS6_LEPBA ;  Q04SA6, HIS6_LEPBJ ;  Q050D2, HIS6_LEPBL ;
DR   Q9ZGM0, HIS6_LEPBO ;  B0SRP0, HIS6_LEPBP ;  P62451, HIS6_LEPIC ;
DR   P59119, HIS6_LEPIN ;  Q9S4H7, HIS6_LEPIR ;  Q03VY0, HIS6_LEUMM ;
DR   B2GBR5, HIS6_LIMF3 ;  Q92E88, HIS6_LISIN ;  C1L0J2, HIS6_LISMC ;
DR   Q722Y7, HIS6_LISMF ;  B8DA62, HIS6_LISMH ;  Q8Y9G5, HIS6_LISMO ;
DR   A0AG15, HIS6_LISW6 ;  B1HVQ1, HIS6_LYSSC ;  A0LCF3, HIS6_MAGMM ;
DR   Q2VYJ0, HIS6_MAGSA ;  Q65RC1, HIS6_MANSM ;  Q0AP84, HIS6_MARMM ;
DR   A6VTA6, HIS6_MARMS ;  A1U5H5, HIS6_MARN8 ;  A6UUZ9, HIS6_META3 ;
DR   Q8TT96, HIS6_METAC ;  Q0W358, HIS6_METAR ;  A7I616, HIS6_METB6 ;
DR   Q46CC5, HIS6_METBF ;  Q12UY6, HIS6_METBU ;  B7KPM8, HIS6_METC4 ;
DR   Q603K3, HIS6_METCA ;  A9W5U0, HIS6_METEP ;  Q1H4R2, HIS6_METFK ;
DR   Q2FPV1, HIS6_METHJ ;  Q57854, HIS6_METJA ;  Q8TYW8, HIS6_METKA ;
DR   A2STB8, HIS6_METLZ ;  A4G0J7, HIS6_METM5 ;  A9A8U1, HIS6_METM6 ;
DR   A6VHY8, HIS6_METM7 ;  Q8PW92, HIS6_METMA ;  A3CT78, HIS6_METMJ ;
DR   P62454, HIS6_METMP ;  B8IPH3, HIS6_METNO ;  B1ZAD6, HIS6_METPB ;
DR   B8GEX3, HIS6_METPE ;  A2SE09, HIS6_METPP ;  B1LUA2, HIS6_METRJ ;
DR   A5UMZ1, HIS6_METS3 ;  B0UHR5, HIS6_METS4 ;  A4YI34, HIS6_METS5 ;
DR   B8EM84, HIS6_METSB ;  Q2NI84, HIS6_METST ;  O27398, HIS6_METTH ;
DR   A6UR05, HIS6_METVS ;  B0JY78, HIS6_MICAN ;  C5CBK1, HIS6_MICLC ;
DR   Q2RGW2, HIS6_MOOTA ;  A0QHH6, HIS6_MYCA1 ;  B1MBX3, HIS6_MYCA9 ;
DR   Q7VEW8, HIS6_MYCBO ;  A1KJ21, HIS6_MYCBP ;  C1ANM7, HIS6_MYCBT ;
DR   A4T9N2, HIS6_MYCGI ;  B8ZRB4, HIS6_MYCLB ;  Q9X7C2, HIS6_MYCLE ;
DR   B2HQA8, HIS6_MYCMM ;  P60666, HIS6_MYCPA ;  A0QX87, HIS6_MYCS2 ;
DR   A3Q125, HIS6_MYCSJ ;  A1UHK2, HIS6_MYCSK ;  Q1B7H0, HIS6_MYCSS ;
DR   A5U2W1, HIS6_MYCTA ;  P9WMM2, HIS6_MYCTO ;  P9WMM3, HIS6_MYCTU ;
DR   A0PP20, HIS6_MYCUA ;  A1T8W7, HIS6_MYCVP ;  Q1D4M4, HIS6_MYXXD ;
DR   Q3INY2, HIS6_NATPD ;  B2A6X0, HIS6_NATTJ ;  B9L718, HIS6_NAUPA ;
DR   Q5FA23, HIS6_NEIG1 ;  B4RJN3, HIS6_NEIG2 ;  A9M2Q5, HIS6_NEIM0 ;
DR   Q9JVH5, HIS6_NEIMA ;  Q9K0H4, HIS6_NEIMB ;  A1KSN6, HIS6_NEIMF ;
DR   Q0AEU1, HIS6_NITEC ;  Q820Q0, HIS6_NITEU ;  Q1QRX0, HIS6_NITHX ;
DR   A9A5X0, HIS6_NITMS ;  Q2YAV0, HIS6_NITMU ;  Q3J6Q1, HIS6_NITOC ;
DR   A6Q117, HIS6_NITSB ;  Q3SWF1, HIS6_NITWN ;  Q5YYP3, HIS6_NOCFA ;
DR   A1SL56, HIS6_NOCSJ ;  Q8YT31, HIS6_NOSS1 ;  Q8ESS2, HIS6_OCEIH ;
DR   Q316L4, HIS6_OLEA2 ;  B1ZX57, HIS6_OPITP ;  A1R5S1, HIS6_PAEAT ;
DR   A1TL06, HIS6_PARC0 ;  A6LDI7, HIS6_PARD8 ;  A1B388, HIS6_PARDP ;
DR   A7HSH0, HIS6_PARL1 ;  B2JHX9, HIS6_PARP8 ;  B2SZ59, HIS6_PARPJ ;
DR   Q13TR0, HIS6_PARXL ;  Q9CLM0, HIS6_PASMU ;  Q6D406, HIS6_PECAS ;
DR   C6DF71, HIS6_PECCP ;  B4SFM7, HIS6_PELPB ;  A5CZ73, HIS6_PELTS ;
DR   Q4FNT7, HIS6_PELUB ;  C0QPQ6, HIS6_PERMH ;  A9BJZ9, HIS6_PETMO ;
DR   Q7N6I5, HIS6_PHOLL ;  P62452, HIS6_PHOPR ;  A6L6Z2, HIS6_PHOV8 ;
DR   A4SV20, HIS6_POLAQ ;  A1VK42, HIS6_POLNA ;  B1XSV3, HIS6_POLNS ;
DR   Q12FC7, HIS6_POLSJ ;  B4S9G0, HIS6_PROA2 ;  A3PBF2, HIS6_PROM0 ;
DR   A2C0N7, HIS6_PROM1 ;  A8G3E4, HIS6_PROM2 ;  A9BE47, HIS6_PROM4 ;
DR   A2BV90, HIS6_PROM5 ;  Q31CA5, HIS6_PROM9 ;  Q7VDF1, HIS6_PROMA ;
DR   B4ESZ8, HIS6_PROMH ;  Q7V2P2, HIS6_PROMP ;  A2BPR2, HIS6_PROMS ;
DR   Q46GY9, HIS6_PROMT ;  Q48C81, HIS6_PSE14 ;  Q15RU3, HIS6_PSEA6 ;
DR   A6VDQ9, HIS6_PSEA7 ;  B7V3N3, HIS6_PSEA8 ;  Q02EM6, HIS6_PSEAB ;
DR   B8H6U2, HIS6_PSECP ;  Q1I3G8, HIS6_PSEE4 ;  Q4KJS4, HIS6_PSEF5 ;
DR   C3K6V3, HIS6_PSEFS ;  A4Y083, HIS6_PSEMY ;  A5VX76, HIS6_PSEP1 ;
DR   Q3KJI5, HIS6_PSEPF ;  B0KI45, HIS6_PSEPG ;  Q88R41, HIS6_PSEPK ;
DR   B1JED1, HIS6_PSEPW ;  Q87UG4, HIS6_PSESM ;  Q3ICD4, HIS6_PSET1 ;
DR   Q4ZLQ2, HIS6_PSEU2 ;  Q4FPZ3, HIS6_PSYA2 ;  Q1Q835, HIS6_PSYCK ;
DR   A1SVC5, HIS6_PSYIN ;  A5WHT5, HIS6_PSYWF ;  Q8ZY16, HIS6_PYRAE ;
DR   P58800, HIS6_PYRFU ;  Q8XV85, HIS6_RALN1 ;  B2UEE5, HIS6_RALPJ ;
DR   A9WR62, HIS6_RENSM ;  Q98CT1, HIS6_RHILO ;  Q92TB3, HIS6_RHIME ;
DR   A5V9W0, HIS6_RHIWR ;  Q7UKJ9, HIS6_RHOBA ;  O30724, HIS6_RHOCB ;
DR   B6IWI7, HIS6_RHOCS ;  C1A0L6, HIS6_RHOE4 ;  Q0SHY7, HIS6_RHOJR ;
DR   C1ATY7, HIS6_RHOOB ;  Q2J340, HIS6_RHOP2 ;  Q07UQ9, HIS6_RHOP5 ;
DR   P60667, HIS6_RHOPA ;  Q21CK1, HIS6_RHOPB ;  Q13E40, HIS6_RHOPS ;
DR   B3Q951, HIS6_RHOPT ;  Q2RNA7, HIS6_RHORT ;  Q162Q1, HIS6_ROSDO ;
DR   A5UY52, HIS6_ROSS1 ;  Q5LU99, HIS6_RUEPO ;  Q1GEZ3, HIS6_RUEST ;
DR   B8I5V6, HIS6_RUMCH ;  A1AV74, HIS6_RUTMC ;  Q21NH5, HIS6_SACD2 ;
DR   O33774, HIS6_SACS2 ;  B5EX44, HIS6_SALA4 ;  A8LX55, HIS6_SALAI ;
DR   A9ML11, HIS6_SALAR ;  Q57MR8, HIS6_SALCH ;  B5FM46, HIS6_SALDC ;
DR   B5QZL7, HIS6_SALEP ;  B5RBR7, HIS6_SALG2 ;  B4T9N9, HIS6_SALHS ;
DR   B4SX46, HIS6_SALNS ;  Q5PDN6, HIS6_SALPA ;  A9N7S0, HIS6_SALPB ;
DR   C0Q1J7, HIS6_SALPC ;  B5BFB5, HIS6_SALPK ;  Q2S295, HIS6_SALRD ;
DR   B4TMS0, HIS6_SALSV ;  P0A1R3, HIS6_SALTI ;  A4X9P7, HIS6_SALTO ;
DR   P0A1R2, HIS6_SALTY ;  A8GC74, HIS6_SERP5 ;  A1S6Z6, HIS6_SHEAM ;
DR   B8E999, HIS6_SHEB2 ;  A3D5B1, HIS6_SHEB5 ;  A6WP22, HIS6_SHEB8 ;
DR   A9L4C0, HIS6_SHEB9 ;  Q12NT0, HIS6_SHEDO ;  Q083K1, HIS6_SHEFN ;
DR   B0TQY8, HIS6_SHEHH ;  A3QF21, HIS6_SHELP ;  Q8CX42, HIS6_SHEON ;
DR   A8H5E5, HIS6_SHEPA ;  A4Y7H2, HIS6_SHEPC ;  B8CR54, HIS6_SHEPW ;
DR   A0KWB0, HIS6_SHESA ;  A8FWD1, HIS6_SHESH ;  Q0HJ99, HIS6_SHESM ;
DR   Q0HUN4, HIS6_SHESR ;  A1RJ16, HIS6_SHESW ;  B1KRF9, HIS6_SHEWM ;
DR   B2TYF5, HIS6_SHIB3 ;  Q323I7, HIS6_SHIBS ;  Q32EF4, HIS6_SHIDS ;
DR   Q0T3A2, HIS6_SHIF8 ;  Q83R03, HIS6_SHIFL ;  Q3Z0G0, HIS6_SHISS ;
DR   Q5WDI2, HIS6_SHOC1 ;  C3MBC1, HIS6_SINFN ;  A6UEK3, HIS6_SINMW ;
DR   Q2NTX6, HIS6_SODGM ;  C4XS73, HIS6_SOLM1 ;  Q01ZU6, HIS6_SOLUE ;
DR   A9GBI6, HIS6_SORC5 ;  Q1GNC3, HIS6_SPHAL ;  A7X763, HIS6_STAA1 ;
DR   A6U558, HIS6_STAA2 ;  Q2FDI8, HIS6_STAA3 ;  A5IWA0, HIS6_STAA9 ;
DR   Q2YZ71, HIS6_STAAB ;  Q5HCM4, HIS6_STAAC ;  A6QKG1, HIS6_STAAE ;
DR   P64361, HIS6_STAAM ;  P64362, HIS6_STAAN ;  Q6GDD1, HIS6_STAAR ;
DR   Q6G602, HIS6_STAAS ;  A8Z5H3, HIS6_STAAT ;  Q8NUI3, HIS6_STAAW ;
DR   B9DIP1, HIS6_STACT ;  Q5HKP2, HIS6_STAEQ ;  Q8CQ92, HIS6_STAES ;
DR   Q4A049, HIS6_STAS1 ;  Q82A99, HIS6_STRAW ;  Q9S2T7, HIS6_STRCO ;
DR   A8AY24, HIS6_STRGC ;  B1W0M6, HIS6_STRGG ;  B4STP2, HIS6_STRM5 ;
DR   B2FPM4, HIS6_STRMK ;  Q8DTR3, HIS6_STRMU ;  A3CNT0, HIS6_STRSV ;
DR   A4VRV9, HIS6_STUS1 ;  Q4J8I9, HIS6_SULAC ;  Q30NR6, HIS6_SULDN ;
DR   A6QCU4, HIS6_SULNB ;  B2V9M8, HIS6_SULSY ;  Q970Z0, HIS6_SULTO ;
DR   Q67KI0, HIS6_SYMTH ;  Q3A137, HIS6_SYNC1 ;  A0LFI1, HIS6_SYNFM ;
DR   Q5N0H4, HIS6_SYNP6 ;  Q0ICA6, HIS6_SYNS3 ;  Q3AWY4, HIS6_SYNS9 ;
DR   Q3ALF6, HIS6_SYNSC ;  Q0AW41, HIS6_SYNWW ;  P74106, HIS6_SYNY3 ;
DR   C5BMF5, HIS6_TERTT ;  Q47QS3, HIS6_THEFY ;  C5A7A2, HIS6_THEGJ ;
DR   Q5JFU8, HIS6_THEKO ;  Q9X0C6, HIS6_THEMA ;  B6YWA9, HIS6_THEON ;
DR   A5INE6, HIS6_THEP1 ;  Q9RPQ4, HIS6_THEP3 ;  B0K629, HIS6_THEPX ;
DR   B9KXJ6, HIS6_THERP ;  B1L873, HIS6_THESQ ;  P62453, HIS6_THET2 ;
DR   Q7SIB9, HIS6_THET8 ;  Q8DJN7, HIS6_THEVB ;  B5YIB7, HIS6_THEYD ;
DR   Q3SEU8, HIS6_THIDA ;  B8GU32, HIS6_THISH ;  C4LFI4, HIS6_TOLAT ;
DR   B3E617, HIS6_TRIL1 ;  Q3MEF5, HIS6_TRIV2 ;  C5CQK0, HIS6_VARPS ;
DR   A1WR24, HIS6_VEREI ;  A5CXY8, HIS6_VESOH ;  B7VGZ7, HIS6_VIBA3 ;
DR   A7MX10, HIS6_VIBC1 ;  A5F289, HIS6_VIBC3 ;  Q9KSW8, HIS6_VIBCH ;
DR   C3LLI5, HIS6_VIBCM ;  Q87QK6, HIS6_VIBPA ;  Q8D8Q5, HIS6_VIBVU ;
DR   Q7MAS1, HIS6_WOLSU ;  Q8PLG6, HIS6_XANAC ;  Q3BUF2, HIS6_XANC5 ;
DR   Q4UU45, HIS6_XANC8 ;  B0RSL9, HIS6_XANCB ;  Q8P9N9, HIS6_XANCP ;
DR   Q2P3J8, HIS6_XANOM ;  Q5H0K6, HIS6_XANOR ;  A7IHN9, HIS6_XANP2 ;
DR   B2I5X6, HIS6_XYLF2 ;  Q9PBD0, HIS6_XYLFA ;  B0U3A8, HIS6_XYLFM ;
DR   Q87C34, HIS6_XYLFT ;  A1JTW3, HIS6_YERE8 ;  A7FJH5, HIS6_YERP3 ;
DR   Q1C9R6, HIS6_YERPA ;  B2JZM4, HIS6_YERPB ;  Q8ZFY0, HIS6_YERPE ;
DR   Q1CGW5, HIS6_YERPN ;  A4TKK8, HIS6_YERPP ;  Q66C54, HIS6_YERPS ;
DR   B1JPW5, HIS6_YERPY ;  Q5NMD6, HIS6_ZYMMO ;
//