ID   4.4.1.42
DE   S-adenosyl-L-methionine lyase.
AN   adenosylmethionine cyclotransferase.
AN   S-adenosyl-L-methionine alkyltransferase (cyclizing).
AN   SAM lyase.
CA   S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-
CA   5'-thioadenosine.
CC   -!- The enzyme was originally described from the yeast Saccharomyces
CC       cerevisiae (as EC 2.5.1.4), though it had not been well
CC       characterized.
CC   -!- It was also incorrectly described from several bacteriophages as a
CC       hydrolase (EC 3.13.2.2).
CC   -!- Later work has shown the bacteriophage enzyme to be a lyase.
CC   -!- The enzyme binds its substrate at the border between two subunits of
CC       a trimeric complex in a position that prevents it from interacting
CC       with water.
CC   -!- Instead, the substrate reacts with itself and splits in two. The
CC       product, L-homoserine lactone, spontaneously hydrolyzes to
CC       L-homoserine.
CC   -!- Formerly EC 2.5.1.4 and EC 3.13.2.2.
DR   P07693, ADOM_BPT3  ;
//