ID   4.6.1.24
DE   ribonuclease T1.
AN   Aspergillus oryzae ribonuclease.
AN   guanyloribonuclease.
AN   RNase N1.
AN   RNase N2.
CA   [RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-
CA   3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].
CC   -!- A family of related enzymes found in some fungi and bacteria.
CC   -!- The enzyme is specific for cleavage at the 3'-phosphate group of
CC       guanosine in single stranded RNA, and catalyzes a two-stage
CC       endonucleolytic cleavage.
CC   -!- The first reaction produces 5'-hydroxy-phosphooligonucletides and
CC       3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic
CC       phosphodiester, which are released from the enzyme.
CC   -!- The enzyme then hydrolyzes these cyclic compounds in a second
CC       reaction that takes place only when all the susceptible
CC       3',5'-phosphodiester bonds have been cyclised.
CC   -!- The second reaction is a reversal of the first reaction using the
CC       hydroxyl group of water instead of the 5'-hydroxyl group of ribose.
CC   -!- The overall process is that of a phosphorus-oxygen lyase followed by
CC       hydrolysis to form the 3'-nucleotides.
CC   -!- Formerly EC 2.7.7.26, EC 3.1.4.8 and EC 3.1.27.3.
DR   Q9TZQ3, PGL1_CAEEL ;  E3M3V1, PGL1_CAERE ;  G5EBV6, PGL3_CAEEL ;
DR   Q7M515, RNA1_ASPPL ;  P00652, RNC2_ASPCL ;  D4AVI0, RNF1_ARTBC ;
DR   P16411, RNF1_GIBBA ;  P10282, RNF1_GIBFU ;  P16412, RNF2_GIBBA ;
DR   P00653, RNMS_ASPPH ;  P09646, RNN1_NEUCR ;  P07446, RNPB_PENBR ;
DR   P09647, RNPC_PENCH ;  P81762, RNPO_PLEOS ;  P30289, RNS3_KITAU ;
DR   P05798, RNSA_KITAU ;  P00650, RNST_SACER ;  P00651, RNT1_ASPOR ;
DR   P26875, RNT1_TRIHA ;  P07736, RNU1_USTSP ;
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