ID   4.98.1.1
DE   protoporphyrin ferrochelatase.
AN   ferrochelatase.
AN   ferro-protoporphyrin chelatase.
AN   heme synthase.
AN   iron chelatase.
AN   protoheme ferro-lyase.
CA   2 H(+) + heme b = Fe(2+) + protoporphyrin IX.
CC   -!- The enzyme catalyzes the terminal step in the heme biosynthesis
CC       pathways of eukaryotes and Gram-negative bacteria.
CC   -!- The reaction is catalyzed only in the reverse direction.
CC   -!- Formerly EC 4.99.1.1.
DR   P39597, EFEB_BACSU ;  Q8XAS4, EFEB_ECO57 ;  A1A9S3, EFEB_ECOK1 ;
DR   Q0TJ48, EFEB_ECOL5 ;  Q8CW71, EFEB_ECOL6 ;  P31545, EFEB_ECOLI ;
DR   Q1RDJ8, EFEB_ECOUT ;  Q31Z86, EFEB_SHIBS ;  Q0T616, EFEB_SHIF8 ;
DR   Q83LK4, EFEB_SHIFL ;  Q3Z396, EFEB_SHISS ;  Q7CI09, EFEB_YERPE ;
DR   Q1CHD5, EFEB_YERPN ;  Q66BP4, EFEB_YERPS ;  P42043, HEMH1_ARATH;
DR   Q69TB1, HEMH1_ORYSJ;  Q8EFF4, HEMH1_SHEON;  O04921, HEMH2_ARATH;
DR   Q0DIV0, HEMH2_ORYSJ;  Q8EBZ7, HEMH2_SHEON;  Q6F7N0, HEMH_ACIAD ;
DR   B7H0X1, HEMH_ACIB3 ;  B7I4A8, HEMH_ACIB5 ;  B2I2R9, HEMH_ACIBC ;
DR   B0VLE0, HEMH_ACIBS ;  A3M1P7, HEMH_ACIBT ;  B0VEC9, HEMH_ACIBY ;
DR   C1F1C7, HEMH_ACIC5 ;  A3N3M9, HEMH_ACTP2 ;  B3H307, HEMH_ACTP7 ;
DR   B0BTL7, HEMH_ACTPJ ;  A0KL51, HEMH_AERHH ;  Q8U9F7, HEMH_AGRFC ;
DR   Q0VSV6, HEMH_ALCBS ;  Q5E6Q7, HEMH_ALIF1 ;  B5FBZ6, HEMH_ALIFM ;
DR   B6EHK1, HEMH_ALISL ;  B9JS40, HEMH_ALLAM ;  O67083, HEMH_AQUAE ;
DR   Q5P1H1, HEMH_AROAE ;  A1K8P4, HEMH_AZOSB ;  C1DEU1, HEMH_AZOVD ;
DR   Q6MHT3, HEMH_BDEBA ;  Q7WGI0, HEMH_BORBR ;  Q7W515, HEMH_BORPA ;
DR   Q7VVX8, HEMH_BORPE ;  P22600, HEMH_BOVIN ;  P28602, HEMH_BRADU ;
DR   A5EBP8, HEMH_BRASB ;  B2SCP3, HEMH_BRUA1 ;  Q2YIS9, HEMH_BRUA2 ;
DR   A6X6W2, HEMH_BRUA4 ;  P0A3D8, HEMH_BRUAB ;  A9MDJ3, HEMH_BRUC2 ;
DR   C0RK28, HEMH_BRUMB ;  P0A3D6, HEMH_BRUME ;  A5VTJ7, HEMH_BRUO2 ;
DR   A9WXE2, HEMH_BRUSI ;  P0A3D7, HEMH_BRUSU ;  B1YTJ5, HEMH_BURA4 ;
DR   A0K4S2, HEMH_BURCH ;  Q0BI24, HEMH_BURCM ;  Q39JD2, HEMH_BURL3 ;
DR   A3MNA4, HEMH_BURM7 ;  A2S570, HEMH_BURM9 ;  Q62HD1, HEMH_BURMA ;
DR   A1V0U1, HEMH_BURMS ;  B1JW14, HEMH_BURO0 ;  Q1BYX9, HEMH_BURO1 ;
DR   A3NYY2, HEMH_BURP0 ;  Q3JP06, HEMH_BURP1 ;  A3ND73, HEMH_BURP6 ;
DR   Q63R43, HEMH_BURPS ;  Q2SYZ9, HEMH_BURTA ;  A4JBR6, HEMH_BURVG ;
DR   A7ZE60, HEMH_CAMC1 ;  A0RNU4, HEMH_CAMFF ;  A8FKS9, HEMH_CAMJ8 ;
DR   A7H4N6, HEMH_CAMJD ;  Q9PI08, HEMH_CAMJE ;  A1VYL5, HEMH_CAMJJ ;
DR   Q5HVR0, HEMH_CAMJR ;  P57777, HEMH_CAUVC ;  B8GW40, HEMH_CAUVN ;
DR   Q11ES4, HEMH_CHESB ;  O42479, HEMH_CHICK ;  Q5L6X6, HEMH_CHLAB ;
DR   Q824K8, HEMH_CHLCV ;  Q252Z7, HEMH_CHLFF ;  Q9PJQ6, HEMH_CHLMU ;
DR   Q9Z7V1, HEMH_CHLPN ;  B0B858, HEMH_CHLT2 ;  Q3KLL2, HEMH_CHLTA ;
DR   B0BCC3, HEMH_CHLTB ;  O84492, HEMH_CHLTR ;  Q7NV65, HEMH_CHRVO ;
DR   B5EJ44, HEMH_CITBB ;  B6J5R6, HEMH_COXB1 ;  B6J386, HEMH_COXB2 ;
DR   A9KGX9, HEMH_COXBN ;  Q83FA4, HEMH_COXBU ;  A7MNM8, HEMH_CROS8 ;
DR   P42044, HEMH_CUCSA ;  Q1LPN9, HEMH_CUPMC ;  Q0KCJ6, HEMH_CUPNH ;
DR   Q473L7, HEMH_CUPPJ ;  B3R447, HEMH_CUPTR ;  B8HK77, HEMH_CYAP4 ;
DR   Q47HJ6, HEMH_DECAR ;  Q9RV98, HEMH_DEIRA ;  Q6APB0, HEMH_DESPS ;
DR   Q54IA8, HEMH_DICDI ;  Q9V9S8, HEMH_DROME ;  A7ZIN5, HEMH_ECO24 ;
DR   B7UKF5, HEMH_ECO27 ;  B7MDZ7, HEMH_ECO45 ;  B7L7A0, HEMH_ECO55 ;
DR   Q8XD39, HEMH_ECO57 ;  B5Z3Y6, HEMH_ECO5E ;  B7NIF5, HEMH_ECO7I ;
DR   B7MQJ0, HEMH_ECO81 ;  B7M3W7, HEMH_ECO8A ;  C4ZUS9, HEMH_ECOBW ;
DR   B1XFR2, HEMH_ECODH ;  A7ZXD3, HEMH_ECOHS ;  A1A8E1, HEMH_ECOK1 ;
DR   Q0TKG6, HEMH_ECOL5 ;  Q8FK83, HEMH_ECOL6 ;  B1IZB9, HEMH_ECOLC ;
DR   P23871, HEMH_ECOLI ;  B7N928, HEMH_ECOLU ;  B6I0C7, HEMH_ECOSE ;
DR   B1LJN3, HEMH_ECOSM ;  Q1RF60, HEMH_ECOUT ;  C5BD17, HEMH_EDWI9 ;
DR   A4W7F9, HEMH_ENT38 ;  B2VHX1, HEMH_ERWT9 ;  B7LV14, HEMH_ESCF3 ;
DR   Q14H85, HEMH_FRAT1 ;  A7NBJ3, HEMH_FRATF ;  Q2A406, HEMH_FRATH ;
DR   B2SDE2, HEMH_FRATM ;  A0Q6Z1, HEMH_FRATN ;  Q0BME1, HEMH_FRATO ;
DR   Q5NFT3, HEMH_FRATT ;  A4IYH5, HEMH_FRATW ;  B9M326, HEMH_GEODF ;
DR   Q39ZQ5, HEMH_GEOMG ;  Q747F5, HEMH_GEOSL ;  C6E7U2, HEMH_GEOSM ;
DR   A5GDG7, HEMH_GEOUR ;  B7KGB9, HEMH_GLOC7 ;  Q7NMC7, HEMH_GLOVI ;
DR   Q5FSJ9, HEMH_GLUOX ;  Q4QLD6, HEMH_HAEI8 ;  A5UCU6, HEMH_HAEIE ;
DR   P43868, HEMH_HAEIN ;  C4K332, HEMH_HAMD5 ;  Q17YG0, HEMH_HELAH ;
DR   Q7VHH1, HEMH_HELHP ;  B6JMR9, HEMH_HELP2 ;  B5Z875, HEMH_HELPG ;
DR   Q1CSI9, HEMH_HELPH ;  Q9ZKD4, HEMH_HELPJ ;  B2UUI4, HEMH_HELPS ;
DR   P56107, HEMH_HELPY ;  A9B546, HEMH_HERA2 ;  A4G8D5, HEMH_HERAR ;
DR   P42045, HEMH_HORVU ;  P22830, HEMH_HUMAN ;  Q31EG9, HEMH_HYDCU ;
DR   Q0BWA5, HEMH_HYPNA ;  Q5QVZ8, HEMH_IDILO ;  A6T228, HEMH_JANMA ;
DR   B5Y0N2, HEMH_KLEP3 ;  Q5X7W3, HEMH_LEGPA ;  A5IHG9, HEMH_LEGPC ;
DR   Q5ZYE7, HEMH_LEGPH ;  Q5WZB4, HEMH_LEGPL ;  B0SF60, HEMH_LEPBA ;
DR   Q8GCV0, HEMH_LEPBI ;  Q04NU7, HEMH_LEPBJ ;  Q04X34, HEMH_LEPBL ;
DR   B0SNJ9, HEMH_LEPBP ;  Q65SV7, HEMH_MANSM ;  A6VXF8, HEMH_MARMS ;
DR   A1U0R2, HEMH_MARN8 ;  Q607T4, HEMH_METCA ;  Q1H397, HEMH_METFK ;
DR   A2SIR1, HEMH_METPP ;  B8EJ84, HEMH_METSB ;  B0JRN7, HEMH_MICAN ;
DR   P22315, HEMH_MOUSE ;  Q5F9U6, HEMH_NEIG1 ;  Q9JVA5, HEMH_NEIMA ;
DR   Q9K097, HEMH_NEIMB ;  A1KSY0, HEMH_NEIMF ;  Q82UK8, HEMH_NITEU ;
DR   Q1QI02, HEMH_NITHX ;  Q3JAW7, HEMH_NITOC ;  A6Q2Y9, HEMH_NITSB ;
DR   B2J9P0, HEMH_NOSP7 ;  Q8YQR8, HEMH_NOSS1 ;  B1ZSW3, HEMH_OPITP ;
DR   A2Y3Q5, HEMH_ORYSI ;  Q3YA36, HEMH_PANTR ;  Q7U5G0, HEMH_PARMW ;
DR   B2JGE7, HEMH_PARP8 ;  B2SXB8, HEMH_PARPJ ;  Q6MAW8, HEMH_PARUW ;
DR   Q145F5, HEMH_PARXL ;  P57874, HEMH_PASMU ;  Q6D7Z4, HEMH_PECAS ;
DR   A1ASJ7, HEMH_PELPD ;  Q4FNS1, HEMH_PELUB ;  B4RD10, HEMH_PHEZH ;
DR   Q7N0P6, HEMH_PHOLL ;  Q6LTE0, HEMH_PHOPR ;  B1XL79, HEMH_PICP2 ;
DR   Q12BZ9, HEMH_POLSJ ;  B2RHB4, HEMH_PORG3 ;  Q7MXP4, HEMH_PORGI ;
DR   A3PBP9, HEMH_PROM0 ;  A2C0Y4, HEMH_PROM1 ;  A8G3P0, HEMH_PROM2 ;
DR   A2C7Q7, HEMH_PROM3 ;  A9BEE9, HEMH_PROM4 ;  A2BVI7, HEMH_PROM5 ;
DR   Q31C09, HEMH_PROM9 ;  Q7VD58, HEMH_PROMA ;  B4F1Q1, HEMH_PROMH ;
DR   Q7V6C6, HEMH_PROMM ;  Q7V2F5, HEMH_PROMP ;  A2BQ06, HEMH_PROMS ;
DR   Q46GQ1, HEMH_PROMT ;  Q48MT5, HEMH_PSE14 ;  Q15NQ1, HEMH_PSEA6 ;
DR   A6VC51, HEMH_PSEA7 ;  B7V0K1, HEMH_PSEA8 ;  Q02G19, HEMH_PSEAB ;
DR   Q9HVD7, HEMH_PSEAE ;  Q1IEW1, HEMH_PSEE4 ;  Q4K6B3, HEMH_PSEF5 ;
DR   P57778, HEMH_PSEFC ;  C3KDN7, HEMH_PSEFS ;  A4XR78, HEMH_PSEMY ;
DR   A5VYH6, HEMH_PSEP1 ;  Q3K6Y7, HEMH_PSEPF ;  B0KNF5, HEMH_PSEPG ;
DR   Q88PV4, HEMH_PSEPK ;  B1JER5, HEMH_PSEPW ;  Q888A2, HEMH_PSESM ;
DR   Q4ZXU9, HEMH_PSEU2 ;  Q4FUR3, HEMH_PSYA2 ;  Q1QDQ5, HEMH_PSYCK ;
DR   A5WH56, HEMH_PSYWF ;  Q8XW32, HEMH_RALN1 ;  B2UBQ0, HEMH_RALPJ ;
DR   B3PZU8, HEMH_RHIE6 ;  Q2K4C4, HEMH_RHIEC ;  Q1MBW8, HEMH_RHIJ3 ;
DR   Q98H61, HEMH_RHILO ;  B5ZPG3, HEMH_RHILW ;  Q92M52, HEMH_RHIME ;
DR   Q7UFZ7, HEMH_RHOBA ;  Q59735, HEMH_RHOCA ;  Q2IRD5, HEMH_RHOP2 ;
DR   Q07H58, HEMH_RHOP5 ;  Q6NBF3, HEMH_RHOPA ;  Q13CU0, HEMH_RHOPS ;
DR   B3QF66, HEMH_RHOPT ;  A8GYD7, HEMH_RICB8 ;  Q1RGK5, HEMH_RICBR ;
DR   A8F0B2, HEMH_RICCK ;  Q92FV4, HEMH_RICCN ;  Q4UJN9, HEMH_RICFE ;
DR   Q9ZC84, HEMH_RICPR ;  Q68VM9, HEMH_RICTY ;  B7K399, HEMH_RIPO1 ;
DR   B5EXN2, HEMH_SALA4 ;  A9MLY4, HEMH_SALAR ;  Q57S74, HEMH_SALCH ;
DR   B5FLJ9, HEMH_SALDC ;  B5QU78, HEMH_SALEP ;  B5R613, HEMH_SALG2 ;
DR   B4T9I3, HEMH_SALHS ;  B4SWY3, HEMH_SALNS ;  Q5PFJ1, HEMH_SALPA ;
DR   A9MW82, HEMH_SALPB ;  C0PVE1, HEMH_SALPC ;  B5BD43, HEMH_SALPK ;
DR   B4TMG7, HEMH_SALSV ;  Q8Z8T2, HEMH_SALTI ;  P37408, HEMH_SALTY ;
DR   O59786, HEMH_SCHPO ;  A8GAV7, HEMH_SERP5 ;  Q12KR9, HEMH_SHEDO ;
DR   B2U4S8, HEMH_SHIB3 ;  Q325C1, HEMH_SHIBS ;  Q32J55, HEMH_SHIDS ;
DR   Q0T7B0, HEMH_SHIF8 ;  Q83SE5, HEMH_SHIFL ;  Q3Z4S4, HEMH_SHISS ;
DR   Q2NV56, HEMH_SODGM ;  B4SNS0, HEMH_STRM5 ;  A4VKZ1, HEMH_STUS1 ;
DR   Q30S35, HEMH_SULDN ;  B2V955, HEMH_SULSY ;  Q31S00, HEMH_SYNE7 ;
DR   Q2JVK5, HEMH_SYNJA ;  Q2JHZ4, HEMH_SYNJB ;  Q5N2B2, HEMH_SYNP6 ;
DR   A5GJF5, HEMH_SYNPW ;  A5GS98, HEMH_SYNR3 ;  Q0I8L9, HEMH_SYNS3 ;
DR   Q3ALP2, HEMH_SYNSC ;  P54225, HEMH_SYNY3 ;  C5BIF4, HEMH_TERTT ;
DR   Q9HLB8, HEMH_THEAC ;  Q72L32, HEMH_THET2 ;  Q8DGU6, HEMH_THEVB ;
DR   Q978U9, HEMH_THEVO ;  Q3SHA3, HEMH_THIDA ;  B8GU82, HEMH_THISH ;
DR   Q10WR6, HEMH_TRIEI ;  Q3MCT9, HEMH_TRIV2 ;  B7VII4, HEMH_VIBA3 ;
DR   Q9KTB6, HEMH_VIBCH ;  Q87RH3, HEMH_VIBPA ;  Q8DFM2, HEMH_VIBVU ;
DR   Q7MMR4, HEMH_VIBVY ;  Q8D226, HEMH_WIGBR ;  Q73FY6, HEMH_WOLPM ;
DR   B3CLU1, HEMH_WOLPP ;  Q7M7P9, HEMH_WOLSU ;  Q5GRR7, HEMH_WOLTR ;
DR   C0R4L0, HEMH_WOLWR ;  Q8PEX0, HEMH_XANAC ;  Q8P3H6, HEMH_XANCP ;
DR   O57478, HEMH_XENLA ;  B2I7H7, HEMH_XYLF2 ;  Q9PFU1, HEMH_XYLFA ;
DR   B0U456, HEMH_XYLFM ;  Q87B82, HEMH_XYLFT ;  P16622, HEMH_YEAST ;
DR   A1JNA4, HEMH_YERE8 ;  P43413, HEMH_YEREN ;  A7FL85, HEMH_YERP3 ;
DR   Q1C4Q0, HEMH_YERPA ;  B2K6Z7, HEMH_YERPB ;  Q8ZC98, HEMH_YERPE ;
DR   A9R0Q8, HEMH_YERPG ;  Q1CL26, HEMH_YERPN ;  A4TPA3, HEMH_YERPP ;
DR   Q05338, HEMH_YERPS ;  B1JHN0, HEMH_YERPY ;  P57779, HEMH_ZYMMO ;
//