ENZYME entry: EC 5.1.1.23
Accepted Name |
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase.
|
Alternative Name(s) |
UDP-MurNAc-L-Ala-L-Glu epimerase. |
Reaction catalysed |
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + H(2)O <=> AMP + diphosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate |
Comment(s) |
- The enzyme, characterized from the bacterium Xanthomonas oryzae,
catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl-
alpha-D-muramoyl-L-alanyl-L-glutamate.
- The reaction proceeds only in one direction and involves an
adenylated intermediate.
- The combined activity of this enzyme and EC 6.3.2.53 provides an
alternative route for incorporating D-glutamate into peptidoglycan,
replacing the more common combination of EC 5.1.1.3 and EC 6.3.2.9.
|
Cross-references |
BRENDA | 5.1.1.23 |
EC2PDB | 5.1.1.23 |
ExplorEnz | 5.1.1.23 |
PRIAM enzyme-specific profiles | 5.1.1.23 |
KEGG Ligand Database for Enzyme Nomenclature | 5.1.1.23 |
IUBMB Enzyme Nomenclature | 5.1.1.23 |
IntEnz | 5.1.1.23 |
MEDLINE | Find literature relating to 5.1.1.23 |
MetaCyc | 5.1.1.23 |
Rhea expert-curated reactions | 5.1.1.23 |
UniProtKB/Swiss-Prot |
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