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ENZYME entry: EC 5.1.1.23

Accepted Name
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase.
Alternative Name(s)
UDP-MurNAc-L-Ala-L-Glu epimerase.
Reaction catalysed
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + H(2)O <=> AMP + diphosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
Comment(s)
  • The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl- alpha-D-muramoyl-L-alanyl-L-glutamate.
  • The reaction proceeds only in one direction and involves an adenylated intermediate.
  • The combined activity of this enzyme and EC 6.3.2.53 provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3 and EC 6.3.2.9.
Cross-references
BRENDA5.1.1.23
EC2PDB5.1.1.23
ExplorEnz5.1.1.23
PRIAM enzyme-specific profiles5.1.1.23
KEGG Ligand Database for Enzyme Nomenclature5.1.1.23
IUBMB Enzyme Nomenclature5.1.1.23
IntEnz5.1.1.23
MEDLINEFind literature relating to 5.1.1.23
MetaCyc5.1.1.23
Rhea expert-curated reactions5.1.1.23
UniProtKB/Swiss-Prot
C4RJF8, MURL_MICS3;  A4X982, MURL_SALTO;  P0DQD8, MURL_XANOM;  

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