ID   5.4.4.7
DE   hydroperoxy icosatetraenoate isomerase.
AN   epidermal lipoxygenase-3.
CA   a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.
CC   -!- The enzyme from mammals accepts a range of hydroperoxy
CC       icosatetraenoates producing one or several different hydroxy epoxy
CC       icosatrienoates.
CC   -!- The human enzyme has highest activity with (12R)-HPETE producing
CC       (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate,
CC       followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-
CC       11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-
CC       hydroxy-11,12-epoxyicosa-5,9,14-trienoate.
CC   -!- The mouse enzyme has highest activity with (8S)-HPETE, producing
CC       (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate.
CC   -!- The enzymes also have the activity of EC 4.2.1.152.
DR   P51589, CP2J2_HUMAN;  Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;
DR   D3ZKX9, LOXE3_RAT  ;
//