ID 5.6.1.6 DE channel-conductance-controlling ATPase. AN CFTR. AN cystic-fibrosis membrane-conductance-regulating protein. CA ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel. CC -!- ABC-type (ATP-binding cassette-type) ATPase, characterized by the CC presence of two similar ATP-binding domains. CC -!- The enzyme is found in animals, and in humans its absence brings CC about cystic fibrosis. CC -!- Unlike most of the ABC transporters, chloride pumping is not directly CC coupled to ATP hydrolysis. CC -!- Instead, the passive flow of anions through the channel is gated by CC cycles of ATP binding and hydrolysis by the ATP-binding domains. CC -!- The enzyme is also involved in the functioning of other transmembrane CC channels. CC -!- Formerly EC 3.6.3.49. DR Q07DV2, CFTR_AOTNA ; Q00PJ2, CFTR_ATEAB ; Q09YK5, CFTR_ATEGE ; DR P35071, CFTR_BOVIN ; Q2QLF9, CFTR_CALJA ; Q5U820, CFTR_CANLF ; DR Q2QLC5, CFTR_CARPS ; Q00552, CFTR_CAVPO ; Q2IBA1, CFTR_CHLAE ; DR Q07DY5, CFTR_COLGU ; Q1LX78, CFTR_DANRE ; Q07E42, CFTR_DASNO ; DR Q2QL74, CFTR_DIDVI ; Q2IBF6, CFTR_GORGO ; Q2QLA3, CFTR_HORSE ; DR P13569, CFTR_HUMAN ; Q108U0, CFTR_LOXAF ; Q7JII8, CFTR_MACFA ; DR Q7JII7, CFTR_MACFU ; Q00553, CFTR_MACMU ; Q9TUQ2, CFTR_MACNE ; DR Q2QL83, CFTR_MICMU ; P26361, CFTR_MOUSE ; Q09YJ4, CFTR_MUNMU ; DR Q07DW5, CFTR_MUNRE ; Q07E16, CFTR_MUSPF ; Q07DX5, CFTR_NOMLE ; DR Q07DZ6, CFTR_ORNAN ; Q2QLH0, CFTR_OTOGA ; Q2QLE5, CFTR_PANTR ; DR Q9TSP5, CFTR_PAPAN ; Q6PQZ2, CFTR_PIG ; Q2QLB4, CFTR_PLEMO ; DR Q2IBE4, CFTR_PONAB ; Q00554, CFTR_RABIT ; P34158, CFTR_RAT ; DR Q2IBB3, CFTR_RHIFE ; Q09YH0, CFTR_SAIBB ; Q00555, CFTR_SHEEP ; DR P26362, CFTR_SQUAC ; Q5D1Z7, CFTR_TRIVU ; P26363, CFTR_XENLA ; //