ID   5.6.1.6
DE   channel-conductance-controlling ATPase.
AN   CFTR.
AN   cystic-fibrosis membrane-conductance-regulating protein.
CA   ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.
CC   -!- ABC-type (ATP-binding cassette-type) ATPase, characterized by the
CC       presence of two similar ATP-binding domains.
CC   -!- The enzyme is found in animals, and in humans its absence brings
CC       about cystic fibrosis.
CC   -!- Unlike most of the ABC transporters, chloride pumping is not directly
CC       coupled to ATP hydrolysis.
CC   -!- Instead, the passive flow of anions through the channel is gated by
CC       cycles of ATP binding and hydrolysis by the ATP-binding domains.
CC   -!- The enzyme is also involved in the functioning of other transmembrane
CC       channels.
CC   -!- Formerly EC 3.6.3.49.
DR   Q07DV2, CFTR_AOTNA ;  Q00PJ2, CFTR_ATEAB ;  Q09YK5, CFTR_ATEGE ;
DR   P35071, CFTR_BOVIN ;  Q2QLF9, CFTR_CALJA ;  Q5U820, CFTR_CANLF ;
DR   Q2QLC5, CFTR_CARPS ;  Q00552, CFTR_CAVPO ;  Q2IBA1, CFTR_CHLAE ;
DR   Q07DY5, CFTR_COLGU ;  Q1LX78, CFTR_DANRE ;  Q07E42, CFTR_DASNO ;
DR   Q2QL74, CFTR_DIDVI ;  Q2IBF6, CFTR_GORGO ;  Q2QLA3, CFTR_HORSE ;
DR   P13569, CFTR_HUMAN ;  Q108U0, CFTR_LOXAF ;  Q7JII8, CFTR_MACFA ;
DR   Q7JII7, CFTR_MACFU ;  Q00553, CFTR_MACMU ;  Q9TUQ2, CFTR_MACNE ;
DR   Q2QL83, CFTR_MICMU ;  P26361, CFTR_MOUSE ;  Q09YJ4, CFTR_MUNMU ;
DR   Q07DW5, CFTR_MUNRE ;  Q07E16, CFTR_MUSPF ;  Q07DX5, CFTR_NOMLE ;
DR   Q07DZ6, CFTR_ORNAN ;  Q2QLH0, CFTR_OTOGA ;  Q2QLE5, CFTR_PANTR ;
DR   Q9TSP5, CFTR_PAPAN ;  Q6PQZ2, CFTR_PIG   ;  Q2QLB4, CFTR_PLEMO ;
DR   Q2IBE4, CFTR_PONAB ;  Q00554, CFTR_RABIT ;  P34158, CFTR_RAT   ;
DR   Q2IBB3, CFTR_RHIFE ;  Q09YH0, CFTR_SAIBB ;  Q00555, CFTR_SHEEP ;
DR   P26362, CFTR_SQUAC ;  Q5D1Z7, CFTR_TRIVU ;  P26363, CFTR_XENLA ;
//