ID   5.6.2.3
DE   DNA 5'-3' helicase.
AN   5' to 3' DNA helicase.
AN   replication fork helicase.
AN   replicative DNA helicase.
CA   Couples ATP hydrolysis with the unwinding of duplex DNA at the
CA   replication fork by translocating in the 5'-3' direction.
CC   -!- Helicases are motor proteins that can transiently catalyze the
CC       unwinding of energetically stable duplex DNA or RNA molecules by
CC       using ATP hydrolysis as the source of energy.
CC   -!- DNA helicases unwind duplex DNA and are involved in replication,
CC       repair, recombination, transcription, pre-rRNA processing,
CC       and translation initiation.
CC   -!- The best studied DNA 5'-3' helicases are those associated with
CC       replication of the chromosome.
CC   -!- The activity of the prokaryotic replicative helicase (DnaB) is often
CC       stimulated by DNA polymerase III.
CC   -!- As the lagging ssDNA is created, it becomes coated with single-
CC       stranded DNA binding protein (SSB).
CC   -!- Once every 500-2000 nucleotides, primase is stimulated by DnaB
CC       helicase to synthesize a primer at the replication fork.
CC   -!- This primer is elongated by the lagging strand half of DNA polymerase
CC       III holoenzyme.
DR   A1CJ34, CHL1_ASPCL ;  Q4WWE9, CHL1_ASPFU ;  A2QY22, CHL1_ASPNC ;
DR   Q2U587, CHL1_ASPOR ;  Q21489, CHL1_CAEEL ;  Q5AD67, CHL1_CANAL ;
DR   Q6FKT4, CHL1_CANGA ;  Q1E5T3, CHL1_COCIM ;  Q6BZD9, CHL1_DEBHA ;
DR   Q750G3, CHL1_EREGS ;  Q6CIF0, CHL1_KLULA ;  A5DUW8, CHL1_LODEL ;
DR   A1D8E4, CHL1_NEOFI ;  A7UXD4, CHL1_NEUCR ;  A5DNW6, CHL1_PICGU ;
DR   A3LN13, CHL1_PICST ;  O14147, CHL1_SCHPO ;  A7ERG1, CHL1_SCLS1 ;
DR   A7TTL0, CHL1_VANPO ;  Q6CAX3, CHL1_YARLI ;  A6ZWN8, CHL1_YEAS7 ;
DR   P22516, CHL1_YEAST ;  P32270, DDA_BPT4   ;  F1R345, DDX11_DANRE;
DR   Q96FC9, DDX11_HUMAN;  Q6AXC6, DDX11_MOUSE;  Q8X7X9, DING_ECO57 ;
DR   Q8FJN1, DING_ECOL6 ;  P27296, DING_ECOLI ;  P64315, DING_MYCBO ;
DR   A5U229, DING_MYCTA ;  P9WMR4, DING_MYCTO ;  P9WMR5, DING_MYCTU ;
DR   P29741, DING_PHOPR ;  Q57RD7, DING_SALCH ;  Q5PG19, DING_SALPA ;
DR   Q8ZQN7, DING_SALTY ;  Q83LU7, DING_SHIFL ;  Q9URU2, DNA2_SCHPO ;
DR   P38859, DNA2_YEAST ;  P57611, DNAB_BUCAI ;  Q8K932, DNAB_BUCAP ;
DR   Q89A52, DNAB_BUCBP ;  Q8X5V3, DNAB_ECO57 ;  Q8FB22, DNAB_ECOL6 ;
DR   P0ACB0, DNAB_ECOLI ;  Q9X4C9, DNAB_GEOSE ;  O78411, DNAB_GUITH ;
DR   P45256, DNAB_HAEIN ;  Q9ZJM5, DNAB_HELPJ ;  O25916, DNAB_HELPY ;
DR   Q6ABX1, DNAB_LEIXX ;  P59966, DNAB_MYCBO ;  P47340, DNAB_MYCGE ;
DR   Q9F5P4, DNAB_MYCIT ;  P46394, DNAB_MYCLE ;  P75539, DNAB_MYCPN ;
DR   P9WMR2, DNAB_MYCTO ;  P9WMR3, DNAB_MYCTU ;  Q8YZA1, DNAB_NOSS1 ;
DR   Q9CNL6, DNAB_PASMU ;  P51333, DNAB_PORPU ;  Q1XDF3, DNAB_PYRYE ;
DR   O30477, DNAB_RHOMR ;  Q1RI04, DNAB_RICBR ;  Q92HG8, DNAB_RICCN ;
DR   Q4UL62, DNAB_RICFE ;  Q9ZD08, DNAB_RICPR ;  Q68WJ2, DNAB_RICTY ;
DR   P0A1Q5, DNAB_SALTI ;  P0A1Q4, DNAB_SALTY ;  P0ACB1, DNAB_SHIFL ;
DR   Q55418, DNAB_SYNY3 ;  O83097, DNAB_TREPA ;  P49519, DNAB_TRICV ;
DR   P37469, DNAC_BACSU ;  Q8W4M7, ERCC2_ARATH;  A6QLJ0, ERCC2_BOVIN;
DR   Q60452, ERCC2_CRIGR;  Q55G81, ERCC2_DICDI;  P18074, ERCC2_HUMAN;
DR   O08811, ERCC2_MOUSE;  Q3YK19, FANCJ_CHICK;  Q9BX63, FANCJ_HUMAN;
DR   Q5SXJ3, FANCJ_MOUSE;  A0A8J1M587, FANCJ_XENLA;  Q46437, GP1D_CHLMU ;
DR   Q46259, GP1D_CHLPS ;  B0BCM3, GP1D_CHLT2 ;  P0CE16, GP1D_CHLTH ;
DR   P20315, HELIC_BPT3 ;  P03692, HELIC_BPT7 ;  F0NDL2, HELS_SACI5 ;
DR   Q974S1, HELS_SULTO ;  Q58824, HERA_METJA ;  Q8U1P0, HERA_PYRFU ;
DR   Q97WG8, HERA_SACS2 ;  F2Z5Z6, HERA_SULAC ;  Q96YR7, HERA_SULTO ;
DR   A0A0H3DK98, PCRAS_MYCPB;  P75438, PCRAS_MYCPN;  P47486, PCRA_MYCGE ;
DR   P75437, PCRA_MYCPN ;  Q5ZIW1, PEO1_CHICK ;  Q9VL76, PEO1_DROME ;
DR   Q96RR1, PEO1_HUMAN ;  Q8CIW5, PEO1_MOUSE ;  Q6MHJ5, PIF1_BDEBA ;
DR   Q0P9V4, PIF1_CAMJE ;  Q59RQ0, PIF1_CANAL ;  Q7ZV90, PIF1_DANRE ;
DR   Q5AXT5, PIF1_EMENI ;  Q9H611, PIF1_HUMAN ;  Q80SX8, PIF1_MOUSE ;
DR   A5WFR0, PIF1_PSYWF ;  Q1HG60, PIF1_RAT   ;  Q9UUA2, PIF1_SCHPO ;
DR   Q384Y1, PIF1_TRYB2 ;  Q0R4F1, PIF1_XENLA ;  A6ZM04, PIF1_YEAS7 ;
DR   P07271, PIF1_YEAST ;  Q384Y0, PIF2_TRYB2 ;  Q383A1, PIF3_TRYB2 ;
DR   Q381V6, PIF4_TRYB2 ;  Q580X6, PIF5_TRYB2 ;  Q38CE9, PIF6_TRYB2 ;
DR   Q57YG0, PIF7_TRYB2 ;  Q8ILY1, PREX_PLAF7 ;  P26659, RAD15_SCHPO;
DR   P06839, RAD3_YEAST ;  O34481, RECD2_BACSU;  Q9RT63, RECD2_DEIRA;
DR   P57530, RECD_BUCAI ;  Q8K9A8, RECD_BUCAP ;  Q89AB2, RECD_BUCBP ;
DR   P04993, RECD_ECOLI ;  P45158, RECD_HAEIN ;  A0QS28, RECD_MYCS2 ;
DR   P9WHJ0, RECD_MYCTO ;  P9WHJ1, RECD_MYCTU ;  P9WMQ7, RECG_MYCTU ;
DR   P38766, RRM3_YEAST ;  P14565, TRAI1_ECOLI;  P22706, TRAI2_ECOLX;
DR   Q6TDU5, TRAI3_ECOLX;  B5X582, TWIH_ARATH ;  P03006, VG12_BPP22 ;
DR   Q4JC68, XPD_SULAC  ;  Q9HM14, XPD_THEAC  ;  Q58960, Y1565_METJA;
DR   Q60270, Y3508_METJA;  Q58352, Y942_METJA ;  P76257, YOAA_ECOLI ;
DR   P44680, YOAA_HAEIN ;  P50831, YPVA_BACSU ;  Q86YA3, ZGRF1_HUMAN;
DR   Q0VGT4, ZGRF1_MOUSE;
//