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ENZYME entry: EC 6.2.1.40

Accepted Name
4-hydroxybutyrate--CoA ligase (AMP-forming).
Alternative Name(s)
4-hydroxybutyrate--CoA ligase.
4-hydroxybutyrate-CoA synthetase.
Reaction catalysed
4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate
Comment(s)
  • Isolated from the archaeon Metallosphaera sedula.
  • Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle.
  • Cf. EC 6.2.1.56.
Cross-references
BRENDA6.2.1.40
EC2PDB6.2.1.40
ExplorEnz6.2.1.40
PRIAM enzyme-specific profiles6.2.1.40
KEGG Ligand Database for Enzyme Nomenclature6.2.1.40
IUBMB Enzyme Nomenclature6.2.1.40
IntEnz6.2.1.40
MEDLINEFind literature relating to 6.2.1.40
MetaCyc6.2.1.40
Rhea expert-curated reactions6.2.1.40
UniProtKB/Swiss-Prot
A4YDT1, HBCL1_METS5;  A4YDR9, HBCL2_METS5;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-