ID   6.2.1.43
DE   2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase.
CA   2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-
CA   methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate.
CC   -!- The enzyme from the bacterium Streptomyces carzinostaticus is
CC       involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-
CC       naphthoate moiety of the antibiotic neocarzinostatin.
CC   -!- In vitro the enzyme also catalyzes the activation of other
CC       1-naphthoic acid analogs, e.g. 2-hydroxy-5-methyl-1-naphthoate or
CC       2,7-dihydroxy-5-methyl-1-naphthoate.
DR   Q84HC5, NCSB2_STRCZ;
//