ID   6.3.1.9
DE   trypanothione synthase.
AN   TSR synthetase.
CA   (1) spermidine + glutathione + ATP = glutathionylspermidine + ADP +
CA   phosphate + H(+).
CA   (2) glutathionylspermidine + glutathione + ATP = trypanothione + ADP +
CA   phosphate + H(+).
CC   -!- The enzyme, characterized from several trypanosomatids (e.g.
CC       Trypanosoma cruzi) catalyzes two subsequent reactions, leading to
CC       production of trypanothione from glutathione and spermidine.
CC   -!- Some trypanosomatids (e.g. Crithidia species and some Leishmania
CC       species) also contain an enzyme that only carries out the first
CC       reaction (cf. EC 6.3.1.8).
CC   -!- The enzyme is bifunctional, and also catalyzes the hydrolysis of
CC       glutathionylspermidine and trypanothione (cf. EC 3.5.1.78).
DR   O60993, TRYS_CRIFA ;  Q9GT49, TRYS_TRYCC ;
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