ID 6.3.2.14 DE enterobactin synthase. AN 2,3-dihydroxybenzoate--serine ligase. AN N-(2,3-dihydroxybenzoyl)-serine synthetase. CA 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + CA enterobactin + 4 H(+). CC -!- This enzyme complex catalyzes the conversion of three molecules each CC of 2,3-dihydroxybenzoate and L-serine to form the siderophore CC enterobactin. CC -!- In Escherichia coli the complex is formed by EntB (an aryl carrier CC protein that has to be activated by 4'-phosphopantetheine), EntD (a CC phosphopantetheinyl transferase that activates EntB), EntE (catalyzes CC the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB CC to form the covalently arylated form of EntB), and EntF (a four CC domain protein that catalyzes the activation of L-serine by ATP, CC the condensation of the activated L-serine with the activated 2,3- CC dihydroxybenzoate, and the trimerization of three such moieties to a CC single enterobactin molecule). DR P0ADI5, ENTB_ECO57 ; P0ADI4, ENTB_ECOLI ; P0ADI6, ENTB_SHIFL ; DR Q8XBV3, ENTE_ECO57 ; P10378, ENTE_ECOLI ; Q8XBV9, ENTF_ECO57 ; DR P11454, ENTF_ECOLI ; P29698, ENTF_SHIFL ; //