ID   6.3.2.17
DE   tetrahydrofolate synthase.
AN   folate polyglutamate synthetase.
AN   folylpoly(gamma-glutamate) synthase.
AN   folylpoly-gamma-glutamate synthase.
AN   folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase.
AN   folylpolyglutamate synthase.
AN   folylpolyglutamate synthetase.
AN   folylpolyglutamyl synthetase.
AN   formyltetrahydropteroyldiglutamate synthetase.
AN   FPGS.
AN   N(10)-formyltetrahydropteroyldiglutamate synthetase.
AN   tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming).
AN   tetrahydrofolylpolyglutamate synthase.
CA   (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-
CA   5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate.
CC   -!- In some bacteria, a single protein catalyzes both this activity and
CC       that of EC 6.3.2.12, the combined activity of which leads to the
CC       formation of the cofactor polyglutamated tetrahydropteroate
CC       (H4PteGlun), i.e. various tetrahydrofolates (H4folate).
CC   -!- In contrast, the activities are located on separate proteins in most
CC       eukaryotes studied to date.
CC   -!- In Arabidopsis thaliana, this enzyme is present as distinct isoforms
CC       in the mitochondria, the cytosol and the chloroplast.
CC   -!- Each isoform is encoded by a separate gene, a situation that is
CC       unique among eukaryotes.
CC   -!- As the affinity of folate-dependent enzymes increases markedly with
CC       the number of glutamic residues, the tetrahydropteroyl polyglutamates
CC       are the preferred cofactors of C1 metabolism.
CC   -!- The enzymes from different sources (particularly eukaryotes versus
CC       prokaryotes) have different substrate specificities with regard to
CC       one-carbon substituents and the number of glutamate residues present
CC       on the tetrahydrofolates.
DR   Q9HS44, FOLCP_HALSA;  D4GW05, FOLCP_HALVD;  Q05865, FOLC_BACSU ;
DR   A6H751, FOLC_BOVIN ;  P57265, FOLC_BUCAI ;  Q8K9X3, FOLC_BUCAP ;
DR   Q89AT2, FOLC_BUCBP ;  Q09509, FOLC_CAEEL ;  Q924L9, FOLC_CRIGR ;
DR   Q54CY5, FOLC_DICDI ;  P08192, FOLC_ECOLI ;  P43775, FOLC_HAEIN ;
DR   Q05932, FOLC_HUMAN ;  P48760, FOLC_MOUSE ;  I6Y0R5, FOLC_MYCTU ;
DR   P36001, FOLC_YEAST ;  Q9Y893, FOLE_CANAX ;  O13492, FOLE_NEUCR ;
DR   O74742, FOLE_SCHPO ;  B3LJR0, FOLE_YEAS1 ;  B5VSC3, FOLE_YEAS6 ;
DR   A6ZP80, FOLE_YEAS7 ;  C8ZGZ3, FOLE_YEAS8 ;  E7KIA3, FOLE_YEASA ;
DR   E7Q9C7, FOLE_YEASB ;  E7KUJ4, FOLE_YEASL ;  E7NMM0, FOLE_YEASO ;
DR   Q08645, FOLE_YEAST ;  E7QKX4, FOLE_YEASZ ;  F4K2A1, FPGS1_ARATH;
DR   F4J2K2, FPGS2_ARATH;  Q8W035, FPGS3_ARATH;  P15925, FPGS_LACCA ;
//